Daily Cosmetic Research Analysis
Analyzed 33 papers and selected 3 impactful papers.
Summary
Analyzed 33 papers and selected 3 impactful articles.
Selected Articles
1. Skin delivery and anti-inflammatory effects of the anesthetic propofol against psoriasiform lesions through KEAP1/Nrf2/HO-1 pathway activation.
Topical propofol suppressed psoriasiform inflammation by downregulating KEAP1 and activating Nrf2/HO-1, reducing cytokines in keratinocytes, macrophages, and neutrophils. Skin absorption and increased deposition in psoriasiform-like barrier disruption were demonstrated, and in vivo treatment improved lesions in imiquimod-sensitized mice.
Impact: This study identifies a redox-driven mechanism and delivery route for repurposing an anesthetic as a topical anti-psoriatic therapy, integrating multi-cell models, skin permeation data, and an in vivo efficacy signal.
Clinical Implications: Findings support exploring topical propofol formulations for psoriasis to minimize systemic exposure, leveraging Nrf2/HO-1 activation. Human safety, dosing, and formulation stability require clinical development.
Key Findings
- Propofol reduced IL-6, IL-8, and CXCL1 in activated keratinocytes and increased Nrf2 and HO-1 via KEAP1 downregulation.
- Antioxidant activity included 47% DPPH reduction; cytokine/chemokine expression decreased in activated macrophages and mouse neutrophils.
- Topical absorption into pig skin was 1.2 nmol/mg at 3 mM; deposition increased to 3.7 nmol/mg after SC lipid removal.
- In imiquimod-sensitized mice, topical propofol suppressed erythema, acanthosis, immune cell infiltration, and reduced epidermal thickness and cytokines.
Methodological Strengths
- Integrated in vitro (keratinocytes, macrophages, neutrophils) and in vivo (IMQ mouse) validation
- Mechanistic linkage to KEAP1/Nrf2/HO-1 with functional readouts and skin permeation quantification
Limitations
- Preclinical data without human pharmacokinetic or safety assessment
- Dose, formulation, and long-term safety for chronic topical use remain untested
Future Directions: Develop optimized topical formulations and conduct phase I/II trials assessing safety, local tolerability, and biomarker modulation (Nrf2/HO-1) in psoriasis.
2. Reparative Effects of 3D-Printed PLGA/CHA/nmZnO Composite Scaffolds on Inflammatory Periodontal Bone Defects in Rats.
A 3D-printed PLGA/CHA/nmZnO scaffold with 30% filler content optimized osteogenesis and immune modulation in a rat periodontitis bone defect model, surpassing Bio-Oss at 12 weeks. The scaffold increased BV/TV and collagen formation while downregulating TLR2, TLR7, and IL-1β.
Impact: This work integrates antibacterial components and immune modulation into a printable scaffold, demonstrating superior bone regeneration to a clinical reference graft and offering a new design paradigm for regenerative periodontics and facial aesthetics.
Clinical Implications: Although preclinical, the 30% PLGA/CHA/nmZnO scaffold suggests a path toward fewer surgeries and better cosmetic/functional outcomes in periodontal and maxillofacial regeneration, potentially outperforming current xenografts.
Key Findings
- 3D-printed scaffolds had interconnected porosity and suitable mechanics with contact angles 73–85°.
- 25–35% CHA/nmZnO enhanced BMSC proliferation and osteogenic differentiation; 30% was optimal.
- In vivo, 30% scaffold increased BV/TV and BS/TV, boosted collagen area, and reduced trabecular separation at 6 weeks.
- At 12 weeks, new bone volume fraction and collagen area exceeded Bio-Oss; TLR2, TLR7, and IL-1β expression were suppressed.
Methodological Strengths
- Systematic comparison of filler content with both in vitro and in vivo endpoints
- Benchmarking against a clinical standard (Bio-Oss) and inclusion of immunohistochemical markers
Limitations
- Animal model findings may not fully translate to human periodontal defects
- Long-term degradation behavior and functional loading outcomes were not reported
Future Directions: Scale-up manufacturing, large-animal models under functional load, and early-phase clinical trials comparing to standard grafts in periodontal regeneration.
3. Reverse expansion-assisted high-quality autologous fat grafting in breast reconstruction: A retrospective comparative study.
In 55 mastectomy patients undergoing autologous fat grafting, adding reverse expansion significantly increased the retention rate of the second graft and improved BREAST-Q psychosocial well-being and breast satisfaction scores versus fat grafting alone. The strategy may reduce the number of grafting sessions while enhancing contour.
Impact: Provides comparative clinical evidence that reverse expansion enhances graft take and patient-reported outcomes, informing practice in aesthetic and reconstructive breast surgery.
Clinical Implications: Consider reverse expansion to precondition recipient sites in staged breast reconstruction with fat grafting to improve retention and reduce sessions, especially where skin envelope and contour are limiting.
Key Findings
- Second fat graft retention (first after RE) was significantly higher with RE+FG than FG alone (P<0.001).
- BREAST-Q postoperative psychosocial well-being and breast satisfaction were significantly better in RE+FG (P<0.05).
- No differences in preoperative scores or first graft retention between groups (P>0.05).
- RE can provide sufficient skin expansion and improved contour without relying on patient compliance.
Methodological Strengths
- Comparative cohort design with objective retention metrics and validated patient-reported outcomes (BREAST-Q)
- Clear timepoint definition (second graft post-RE) for primary endpoint
Limitations
- Retrospective single-center study with potential selection bias and unmeasured confounders
- Follow-up duration and complication profiles are not detailed
Future Directions: Prospective multicenter trials with standardized volumetric imaging and longer follow-up to assess durability, complications, and cost-effectiveness.