Cosmetic Medicine - Papers

The authors present a yeast-based biocatalytic platform that systematically introduces extra carbons into diverse isoprenoid classes, enabling production of analogs with tailored properties. Proof-of-concept includes biosynthesis of ethyllinalool and cannabinoid analogs with enhanced receptor agonism, highlighting broad utility for fragrance and bioactive discovery.

The study shows that oral zinc gluconate can self-assemble with plasma proteins into ZnO nanoparticles in vivo, which preferentially accumulate in papillary Caki-2 renal tumors. This accumulation enhances antitumor immunity by recruiting dendritic cells and cytotoxic CD8+ T cells, suggesting an accessible oral route for nanomedicine-based immunotherapy.

Across human cohorts and mouse models, the authors identify a GLP-1–mediated gut–joint axis in osteoarthritis. Reduced GUDCA and FXR signaling modulate intestinal GLP-1, and pharmacologic manipulation of the GLP-1 receptor respectively attenuates or exacerbates osteoarthritic pathology.

Using multi-modal analyses and scRNA-seq, the study identifies an NRP1-high endothelial subset driving endothelial-to-mesenchymal transition and abnormal scar vasculature. Inhibiting NRP1 normalizes vessels and prevents scarring in mice, and a peptide-loaded hydrogel spray translates this mechanism into a tractable anti-scar strategy.

This paper establishes the first scalable, high-yield (>40%) and high-purity (>95% without chromatography) synthesis of δ-cyclodextrin (nine glucose units) using enzyme-mediated dynamic combinatorial chemistry and a dodecaborate template. The method enables multigram production, unlocking applications in cosmetics and pharmaceuticals for encapsulating actives, improving stability, and controlled release.

Using Arctic ice-core lead records, atmospheric transport modeling, and contemporary exposure–response relationships, the authors infer that Roman-era background air pollution likely elevated population blood lead and contributed to cognitive decline across Europe. The work triangulates paleoclimate archives with modern epidemiology to quantify health effects of ancient industrialization.

Using multi-tracing approaches in mice, the authors show that subcutaneous fascia migrates to encase acellular adipose matrix implants, delivering fascia-embedded vessels and forming a vascular matrix complex critical for implant vascularization and survival. Limiting fascia mobility or removing fascia markedly impairs vascularization and leads to later implant collapse, highlighting fascia as an active driver of regenerative integration.

Intranasal zinc oxide nanoparticles entered the brain via the nose-to-brain route, accumulated in microglia, and triggered microglia-derived NOX2-ROS, leading to neuronal PANoptosis. These mechanistic insights link inhalable nanoparticle exposure to neurotoxicity relevant to consumer products and occupational settings.

In laser-injury and UVB photoaging models, 0.1% recombinant human collagen XVII enhanced skin repair by expanding Lgr6+ epidermal stem cells and activating Wnt/β-catenin signaling. It reduced epidermal thickening and restored skin architecture, providing a mechanistic basis for regenerative dermatology applications.

In a multicenter Phase III RCT of 325 Chinese adults with moderate-to-severe submental fat, MEI005 produced significantly greater clinician- and patient-rated improvements than placebo and achieved meaningful MRI-measured volume reductions. Adverse events were mostly mild to moderate, supporting a minimally invasive option for submental contouring.

In volunteer exposure experiments, applying common personal care products increased dermal adsorption of multiple SVOC classes by roughly 1.6–2.0-fold, with tocopherol-containing formulations further enhancing uptake. Machine-learning predictions indicated significant increases in serum concentrations of 2–3 ring PAHs and TCEP after product use, highlighting ingredient-dependent risks.

Across 250 24-h urine samples (2000–2021), specific metabolites of the UV filter DHHB (DHB, EHB) emerged from 2012 onward, indicating increasing exposure, though estimated intake remained far below a no-effect level. Retrospective dosing experiments demonstrated that di-n-hexyl phthalate (DnHexP) impurities in DHHB lead to measurable phthalate metabolite excretion, suggesting contaminated DHHB can contribute to phthalate exposure.

Using micro-CT-derived topographies from young and aged Korean skin, the authors built PDMS replicas to quantify how age-related roughness and wrinkles alter cosmetic thin-film deposition. The model, further refined by incorporating porosity and sebum, enables standardized age-specific evaluation of film coverage to guide formulation optimization.

This study introduces a Y-shaped DNA molecular pendulum sensor using split aptamers to enable one-step electrochemical detection of small molecules and low-molecular-weight proteins. The stable double-arm configuration provided the broadest dynamic range and strongest signal. It accurately quantified enrofloxacin in diluted milk, artificial urine, and cosmetics (0.001–100 ng/mL) and detected myoglobin by simply changing the recognition strand.

Using NoxiScore, a deep learning-based computational histology pipeline, the authors identified nuclear texture features linked to UV-induced skin damage and showed that sunscreen protected ex vivo human skin whereas concurrent application with an insect repellent significantly reduced UVB protection. Repellent alone had no protective or toxic effect; inter-donor variability was observed.

Two-sample Mendelian randomization using large GWAS datasets indicates that genetically higher triglycerides and LDL-C increase psoriasis risk and that genetically mimicked ANGPTL3 inhibition (as with evinacumab) lowers risks of psoriasis and arthropathic psoriasis. These results support lipid modulation—particularly via ANGPTL3—as a potential preventive or therapeutic strategy in psoriasis.

This preclinical systematic review and meta-analysis of 83 studies finds that MSC-derived EVs improve wound closure, collagen deposition, and revascularization, with ApoSEVs outperforming ApoBDs and sEVs for closure/collagen while sEVs favor revascularization. Subcutaneous administration and ADSC sources were associated with better outcomes, but substantial methodological heterogeneity highlights the need for standardization before clinical translation.

This study assembled >6,000 experimental labels to train explainable ML models that predict eye and skin irritation with balanced accuracies of 73–75%. It identifies structural alert fragments, provides multi-level interpretability, and offers a user-friendly interface, positioning it as a practical alternative-to-animal screening tool for cosmetics and related chemicals.

This first meta-analysis quantifies facial artery depth at five standardized facial levels, reporting mean depths and 95% CIs. The data support superficial injection (≤4.5 mm) at the oral commissure level and highlight substantial depth variability in the nasolabial region, advocating ultrasound assessment in upper nasolabial areas.

This meta-analysis of 7 RCTs and 18 cohort studies shows that prednisone reduces death/transplantation in autoimmune hepatitis, with additional benefit from combining azathioprine. Higher initial steroid doses provide no clear efficacy advantage and increase adverse events. Budesonide offers similar biochemical response to prednisone with fewer cosmetic adverse effects, and mycophenolate is an alternative to azathioprine with fewer serious AEs.

In a triple-blind RCT of 610 preschool children over 24 months, hydroxyapatite-fluoride toothpastes achieved greater inactivation of enamel caries lesions than monofluorophosphate toothpastes. Differences for dentinal lesions were smaller, but the hydroxyapatite group showed more inactivated lesions overall. Both regimens were used three times daily, with 518 completing the trial.

In a 6-month, double-blind, multicenter Phase 3 trial, a ready-to-use liquid botulinum toxin A achieved markedly higher patient-reported responder rates for glabellar line improvement versus placebo, with benefits sustained to Month 6. Patients reported natural-looking results, higher satisfaction, and improved psychological well-being.

The authors introduce GPOSC-Net, combining a landmark prediction module with a latent diffusion model to synthesize realistic post-operative lateral cephalograms from pre-operative inputs. Multi-dataset validation, a visual Turing test, and simulation studies show accurate landmark prediction and high-fidelity image generation, supporting use in planning and patient communication.

The authors present a stretchable microfluidic device that tunes double-emulsion core size, shell thickness, and generation frequency without altering flow rates. Applying ~16% device strain increased core volume ~84% and shell volume ~23%, enabling real-time, on-site formulation control relevant to cosmetics, food, and bioapplications.