Respiratory Research Analysis
Q4-2025 respiratory research pivoted toward platform solutions and host-directed mechanisms that can generalize across pathogens. A protein language model enabled de novo paired-chain antibody design, pointing to a rapid-response biologics paradigm. Vascular adhesion biology (P-selectin) emerged as a modifiable host axis for coronavirus–platelet/endothelium interactions with in vivo clearability. Mucosal vaccine work advanced on two fronts: manufacturing control of defective interfering particle