Ciprofol Versus Propofol for the Prevention of Hypoxia During Gastrointestinal Endoscopy Procedures in Overweight Patients: A Multicenter, Randomized, Controlled Trial.

Summary

In overweight patients undergoing GI endoscopy, ciprofol sedation reduced the combined incidence of hypoxia and severe hypoxia compared with propofol. Secondary outcomes favored ciprofol, including less injection pain and fewer corrective measures for hypoxia, while endoscopy success was comparable.

Key Findings

• Ciprofol reduced the total incidence of hypoxia and severe hypoxia versus propofol in overweight patients during GI endoscopy.
• Secondary outcomes supported ciprofol with lower injection pain and fewer corrective hypoxia interventions.
• Endoscopy success rates were comparable between groups.

Clinical Implications

For overweight patients undergoing GI endoscopy, ciprofol may be preferred over propofol to lower hypoxia risk, with similar procedural success. Institutions should consider updating sedation protocols and monitoring workflows accordingly.

Limitations

• Abstract does not report exact event rates or effect sizes in the public summary
• Conducted in a single country; generalizability to other populations requires caution

Future Directions

Head-to-head trials in diverse populations, mechanistic studies on respiratory physiology under ciprofol, and cost-effectiveness analyses to guide formulary adoption.