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| Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis. Cell research2026-07-31 | 91.5- Design
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| Inflammatory Phenotypes In Severe Pneumonia: Clinical Evidence To Mouse Models For Precision Therapeutics. American journal of respiratory and critical care medicine2026-07-31 | 90.0- Design
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| EGFR orchestrates neutrophil activation and NETosis via CEBPβ-dependent PGLYRP1 induction. Cell death and differentiation2026-01-16 | 88.5- Design
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| Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis. Pain2025-01-21 | 88.5- Design
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| Ferroptosis inhibition enhances liver and lung graft function. Cell2026-05-10 | 88.5- Design
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| TAK-925 (Danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-induced Respiratory Depression and Sedation without Affecting Analgesia in Healthy Men. Anesthesiology2025-01-13 | 88.5- Design
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| Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains. Nature human behaviour2026-01-29 | 88.5- Design
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| Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial. Lancet (London, England)2026-05-05 | 88.5- Design
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| Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial. Journal of translational medicine2025-02-15 | 88.5- Design
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| Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo. The Journal of allergy and clinical immunology2025-02-02 | 88.5- Design
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| Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. The Lancet. Respiratory medicine2026-03-20 | 88.5- Design
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| Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial. BMJ (Clinical research ed.)2025-02-12 | 88.5- Design
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| The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel. Proceedings of the National Academy of Sciences of the United States of America2025-04-03 | 88.5- Design
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| Reinforcement learning based automated anesthesia system for gastrointestinal endoscopy with a multicenter randomized trial. NPJ digital medicine2026-04-30 | 88.5- Design
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| Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy. Neuron2026-02-26 | 88.5- Design
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| Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels. Nature neuroscience2026-07-23 | 88.5- Design
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| A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial. Lancet (London, England)2025-11-17 | 88.5- Design
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| Comprehensive profiling of brain dynamics during anesthesia across phylogeny. Nature neuroscience2026-09-30 | 87.0- Design
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| Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial. Nature medicine2025-09-30 | 87.0- Design
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| Molecular architecture of human dermal sleeping nociceptors. Cell2026-02-06 | 87.0- Design
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| Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain. Neuron2025-03-29 | 87.0- Design
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| Hypothalamic clock governs circadian pain. Science (New York, N.Y.)2026-03-20 | 87.0- Design
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| Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis. The Journal of clinical investigation2026-01-16 | 87.0- Design
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| Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1-mediated accumulation of perivascular macrophages. Science advances2025-04-16 | 87.0- Design
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| Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial. JAMA internal medicine2026-03-17 | 87.0- Design
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| Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA2025-10-29 | 87.0- Design
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| Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell2025-05-21 | 87.0- Design
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| Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis-Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025-07-22 | 87.0- Design
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| Synchronicity of pyramidal neurones in the neocortex dominates isoflurane-induced burst suppression in mice. British journal of anaesthesia2025-02-01 | 87.0- Design
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| A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity. Science advances2025-01-03 | 87.0- Design
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| TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress. The Journal of clinical investigation2026-03-03 | 87.0- Design
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| Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials. EClinicalMedicine2025-01-13 | 86.0- Design
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| Conventional vs Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubations: A Randomized Clinical Trial. JAMA network open2026-08-03 | 85.5- Design
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| Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions. Proceedings of the National Academy of Sciences of the United States of America2026-03-20 | 85.5- Design
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| Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis. BMJ (Clinical research ed.)2026-04-10 | 85.5- Design
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| HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial. Intensive care medicine2026-06-29 | 85.5- Design
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| General Anesthesia-activated Neurons in the Central Amygdala Mediate Antinociception: Distinct Roles in Acute versus Chronic Phases of Nerve Injury. Anesthesiology2025-05-07 | 85.5- Design
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| Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor. Nature2025-12-23 | 85.5- Design
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| Effects of Sedative Doses of Propofol, Dexmedetomidine, and Fentanyl on Memory and Pain in Healthy Young Adults: A Randomized, Controlled, Single-blind Crossover Study Using Functional Magnetic Resonance Imaging at 7 Tesla. Anesthesiology2025-04-09 | 85.5- Design
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| Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial. Lancet (London, England)2026-07-08 | 85.5- Design
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| Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness. Critical care (London, England)2025-09-26 | 85.5- Design
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| Structural basis of opioid receptor activation by PCP and ketamine. Nature structural & molecular biology2026-06-23 | 85.5- Design
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| Multimodal Prehabilitation for Older Adults Undergoing Spinal Fusion : A Randomized Clinical Trial. Annals of internal medicine2026-06-15 | 85.5- Design
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| NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials. Nature communications2026-05-06 | 85.5- Design
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| Mitochondrial flagella-like extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysregulation in sepsis. Nature communications2026-05-26 | 85.5- Design
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| Ketamine-induced Sustained Modulation of γ-Aminobutyric Acid Type A Receptor Function in Mouse Hippocampal Neurons after Anesthesia. Anesthesiology2025-06-09 | 85.5- Design
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| Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study. BMC medicine2026-04-07 | 85.5- Design
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| Striatal neurones expressing D1 dopamine receptors modulate consciousness in sevoflurane but not propofol anaesthesia in mice. British journal of anaesthesia2025-02-07 | 85.5- Design
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| Sensory neuron BRAF mediates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity. The Journal of clinical investigation2026-07-14 | 85.5- Design
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