Daily Ards Research Analysis
Analyzed 1 papers and selected 3 impactful papers.
Summary
Analyzed 1 papers and selected 3 impactful articles.
Selected Articles
1. Hypoalbuminaemia contributes to postoperative pulmonary complications and mortality: a systematic review and meta-analysis.
This registered systematic review and meta-analysis pooled 40 studies (n=477,701) and found preoperative hypoalbuminaemia was associated with higher adjusted odds of postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32). The association magnitude differed by type of surgery; sensitivity analyses were conducted to assess robustness.
Impact: Large, registered synthesis demonstrating a consistent and substantial association between hypoalbuminaemia and clinically important postoperative outcomes; informs perioperative risk assessment and potential interventional trials.
Clinical Implications: Preoperative albumin should be considered in risk stratification for PPCs and mortality; patients with hypoalbuminaemia may benefit from closer respiratory monitoring, nutritional optimization, and prospective trials testing albumin-corrective strategies to reduce PPCs and mortality.
Key Findings
- Meta-analysis of 40 studies (n=477,701) showed preoperative hypoalbuminaemia predicts postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32).
- The strength of association varied by surgery type, indicating heterogeneity in risk across surgical populations.
- The review was registered (CRD42024540493), used quality assessment (Newcastle–Ottawa Scale), and performed sensitivity analyses, supporting robustness of findings.
Methodological Strengths
- Prospective registration of the review (CRD42024540493) and comprehensive database search across multiple sources.
- Large pooled sample (477,701 patients) with adjusted effect estimates, use of quality assessment (Newcastle–Ottawa Scale) and sensitivity analyses.
Limitations
- Included studies are observational, so residual confounding and inability to infer causality remain.
- Heterogeneity across studies and surgical types; incomplete reporting in primary studies (e.g., variability in albumin thresholds, timing of measurement).
Future Directions: Conduct prospective trials to test whether preoperative correction of hypoalbuminaemia (nutritional interventions or albumin supplementation) reduces postoperative pulmonary complications and mortality; define optimal albumin thresholds and timing for measurement and intervention.
OBJECTIVE: This review aimed to assess whether hypoalbuminaemia can predict postoperative pulmonary complications (PPCs) and mortality in patients receiving general anaesthesia for surgery. METHODS: PubMed, Web of Science, EMBASE, and the Cochrane Library were searched for relevant articles published up to 18 July 2024. Three authors independently reviewed the studies and assessed the quality of related articles via the Newcastle‒Ottawa Scale. The data were recorded, and a meta-analysis was performed using Review Manager version 5.4.1. RESULTS: A total of 40 studies with 477,701 patients were included in the meta-analysis. Adjusted data were pooled to calculate the odds ratio (OR). A sensitivity test was conducted. A meta-analysis of 18 studies demonstrated that hypoalbuminaemia was a significant predictor of PPCs and mortality after general anaesthesia (OR: 2.88, 95% CI 2.50 to 3.32, P < 0.01, I
2. Hypoalbuminaemia contributes to postoperative pulmonary complications and mortality: a systematic review and meta-analysis.
This registered systematic review and meta-analysis pooled 40 studies (n=477,701) and found preoperative hypoalbuminaemia was associated with higher adjusted odds of postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32). The association magnitude differed by type of surgery; sensitivity analyses were conducted to assess robustness.
Impact: Large, registered synthesis demonstrating a consistent and substantial association between hypoalbuminaemia and clinically important postoperative outcomes; informs perioperative risk assessment and potential interventional trials.
Clinical Implications: Preoperative albumin should be considered in risk stratification for PPCs and mortality; patients with hypoalbuminaemia may benefit from closer respiratory monitoring, nutritional optimization, and prospective trials testing albumin-corrective strategies to reduce PPCs and mortality.
Key Findings
- Meta-analysis of 40 studies (n=477,701) showed preoperative hypoalbuminaemia predicts postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32).
- The strength of association varied by surgery type, indicating heterogeneity in risk across surgical populations.
- The review was registered (CRD42024540493), used quality assessment (Newcastle–Ottawa Scale), and performed sensitivity analyses, supporting robustness of findings.
Methodological Strengths
- Prospective registration of the review (CRD42024540493) and comprehensive database search across multiple sources.
- Large pooled sample (477,701 patients) with adjusted effect estimates, use of quality assessment (Newcastle–Ottawa Scale) and sensitivity analyses.
Limitations
- Included studies are observational, so residual confounding and inability to infer causality remain.
- Heterogeneity across studies and surgical types; incomplete reporting in primary studies (e.g., variability in albumin thresholds, timing of measurement).
Future Directions: Conduct prospective trials to test whether preoperative correction of hypoalbuminaemia (nutritional interventions or albumin supplementation) reduces postoperative pulmonary complications and mortality; define optimal albumin thresholds and timing for measurement and intervention.
OBJECTIVE: This review aimed to assess whether hypoalbuminaemia can predict postoperative pulmonary complications (PPCs) and mortality in patients receiving general anaesthesia for surgery. METHODS: PubMed, Web of Science, EMBASE, and the Cochrane Library were searched for relevant articles published up to 18 July 2024. Three authors independently reviewed the studies and assessed the quality of related articles via the Newcastle‒Ottawa Scale. The data were recorded, and a meta-analysis was performed using Review Manager version 5.4.1. RESULTS: A total of 40 studies with 477,701 patients were included in the meta-analysis. Adjusted data were pooled to calculate the odds ratio (OR). A sensitivity test was conducted. A meta-analysis of 18 studies demonstrated that hypoalbuminaemia was a significant predictor of PPCs and mortality after general anaesthesia (OR: 2.88, 95% CI 2.50 to 3.32, P < 0.01, I
3. Hypoalbuminaemia contributes to postoperative pulmonary complications and mortality: a systematic review and meta-analysis.
This registered systematic review and meta-analysis pooled 40 studies (n=477,701) and found preoperative hypoalbuminaemia was associated with higher adjusted odds of postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32). The association magnitude differed by type of surgery; sensitivity analyses were conducted to assess robustness.
Impact: Large, registered synthesis demonstrating a consistent and substantial association between hypoalbuminaemia and clinically important postoperative outcomes; informs perioperative risk assessment and potential interventional trials.
Clinical Implications: Preoperative albumin should be considered in risk stratification for PPCs and mortality; patients with hypoalbuminaemia may benefit from closer respiratory monitoring, nutritional optimization, and prospective trials testing albumin-corrective strategies to reduce PPCs and mortality.
Key Findings
- Meta-analysis of 40 studies (n=477,701) showed preoperative hypoalbuminaemia predicts postoperative pulmonary complications and mortality (adjusted OR 2.88, 95% CI 2.50–3.32).
- The strength of association varied by surgery type, indicating heterogeneity in risk across surgical populations.
- The review was registered (CRD42024540493), used quality assessment (Newcastle–Ottawa Scale), and performed sensitivity analyses, supporting robustness of findings.
Methodological Strengths
- Prospective registration of the review (CRD42024540493) and comprehensive database search across multiple sources.
- Large pooled sample (477,701 patients) with adjusted effect estimates, use of quality assessment (Newcastle–Ottawa Scale) and sensitivity analyses.
Limitations
- Included studies are observational, so residual confounding and inability to infer causality remain.
- Heterogeneity across studies and surgical types; incomplete reporting in primary studies (e.g., variability in albumin thresholds, timing of measurement).
Future Directions: Conduct prospective trials to test whether preoperative correction of hypoalbuminaemia (nutritional interventions or albumin supplementation) reduces postoperative pulmonary complications and mortality; define optimal albumin thresholds and timing for measurement and intervention.
OBJECTIVE: This review aimed to assess whether hypoalbuminaemia can predict postoperative pulmonary complications (PPCs) and mortality in patients receiving general anaesthesia for surgery. METHODS: PubMed, Web of Science, EMBASE, and the Cochrane Library were searched for relevant articles published up to 18 July 2024. Three authors independently reviewed the studies and assessed the quality of related articles via the Newcastle‒Ottawa Scale. The data were recorded, and a meta-analysis was performed using Review Manager version 5.4.1. RESULTS: A total of 40 studies with 477,701 patients were included in the meta-analysis. Adjusted data were pooled to calculate the odds ratio (OR). A sensitivity test was conducted. A meta-analysis of 18 studies demonstrated that hypoalbuminaemia was a significant predictor of PPCs and mortality after general anaesthesia (OR: 2.88, 95% CI 2.50 to 3.32, P < 0.01, I