ARDS - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper Title	Total	Innovation	Impact	Rigor	Citation
1	Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury. Journal of nanobiotechnology • 2025-02-28	87.0	9	8	9	8
2	First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing properties. The Journal of pharmacology and experimental therapeutics • 2025-02-19	87.0	9	8	9	8
3	Electroacupuncture promotes resolution of inflammation by modulating SPMs via vagus nerve activation in LPS-induced ALI. International immunopharmacology • 2025-01-03	87.0	9	8	9	8
4	H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis. MedComm • 2025-01-17	87.0	9	8	9	8
5	Airway Delivery of Encapsulated Cytokine-Secreting Cells for Local Immunomodulation in Inflammatory Lung Diseases. Research square • 2025-12-08	86.0	9	9	8	9
6	Extracellular peroxiredoxin 6 released from alveolar epithelial cells as a DAMP drives macrophage activation and inflammatory exacerbation in acute lung injury. International immunopharmacology • 2025-01-18	85.5	9	8	9	7
7	Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide-Induced Lung Injury in Obesity. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-02-08	85.5	9	8	9	7
8	PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation. PLoS pathogens • 2025-01-27	85.5	9	7	9	8
9	Inflammation-induced Generation of Splenic Erythroblast-like Ter-Cells Inhibits the Progression of Acute Lung Injury via Artemin. American journal of respiratory cell and molecular biology • 2025-01-06	85.5	9	8	9	7
10	Targeting mTOR in myeloid cells prevents infection-associated inflammation. iScience • 2025-04-03	84.5	9	8	8	9
11	Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial. JAMA • 2025-03-18	84.0	8	9	9	7
12	Identifying potential drug targets for sepsis-related adult respiratory distress syndrome through comprehensive genetic analysis and druggability assessment. Journal of global health • 2025-03-21	83.0	9	8	8	8
13	Extracellular vesicle-bound S100A8/A9 is differentially expressed in septic shock and prompts acute lung injury. Respiratory research • 2025-03-19	83.0	9	8	8	8
14	Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury. Molecular medicine (Cambridge, Mass.) • 2025-02-04	83.0	9	8	8	8
15	PGC-1α mediates migrasome secretion accelerating macrophage-myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis. Experimental & molecular medicine • 2025-04-01	83.0	9	8	8	8
16	Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury. Respiratory research • 2025-04-03	83.0	9	8	8	8
17	Pirfenidone to prevent fibrosis in acute respiratory distress syndrome: The PIONEER study protocol. Contemporary clinical trials • 2025-03-17	82.5	8	8	9	7
18	O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway. BMC biology • 2025-02-04	81.0	8	7	9	7
19	Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis. Annals of internal medicine • 2025-12-01	81.0	7	8	9	8
20	Flow mechanisms of the air-blood barrier. PLoS computational biology • 2025-04-10	80.5	9	8	7	9
21	Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury. bioRxiv : the preprint server for biology • 2025-04-08	80.5	9	8	7	9
22	Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality. The Journal of clinical investigation • 2025-12-02	80.0	8	8	8	8
23	Targeting alveolar epithelial cells with lipid micelle-encapsulated necroptosis inhibitors to alleviate acute lung injury. Communications biology • 2025-04-06	80.0	8	8	8	8
24	Transfusion Practices in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Critical care medicine • 2025-01-29	79.5	7	8	9	7
25	Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity. Journal of biological engineering • 2025-02-04	79.0	9	7	7	9
26	Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia. bioRxiv : the preprint server for biology • 2025-03-10	79.0	9	8	7	8
27	Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence- Based Recommendations for Choosing Modes and Setting Parameters of Mechanical Ventilation. Respiration; international review of thoracic diseases • 2025-12-11	78.5	7	9	8	8
28	Accuracy of artificial intelligence algorithms in predicting acute respiratory distress syndrome: a systematic review and meta-analysis. BMC medical informatics and decision making • 2025-01-29	78.5	8	7	8	8
29	Transforming neonatal nursing: a randomized controlled trial comparing kangaroo care and standard protocols for survival in preterm infants with respiratory distress syndrome. BMC nursing • 2025-04-17	78.0	7	8	9	6
30	IL-35 alleviates ferroptosis in macrophage by activating the NRF2/GPX4 pathway to improve sepsis-induced ARDS. Cytokine • 2025-12-11	77.5	9	8	7	7
31	Identification and Functional Analysis of PANoptosis-Associated Genes in the Progression From Sepsis to ARDS. Immunity, inflammation and disease • 2025-01-24	77.5	9	7	7	8
32	Palmitoylation of TRIM47 Regulates ATG16L1-Mediated Autophagy to Exacerbate Respiratory Distress Syndrome in Sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2025-12-04	77.5	9	8	7	7
33	MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2. Biochimica et biophysica acta. Molecular basis of disease • 2025-03-14	77.5	9	7	7	8
34	FABP4 expression in neutrophils as a predictor of sepsis and SI-ARDS based on BALF transcriptome and peripheral blood validation. Chinese medical journal • 2025-04-02	77.5	9	8	7	7
35	A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Critical care medicine • 2025-02-21	77.0	6	9	8	9
36	Mannose-6-phosphate attenuates acute lung injury by competitive release of acid sphingomyelinase from the mannose-6-phosphate receptor in endothelial caveolae. The European respiratory journal • 2025-02-28	77.0	8	7	8	7
37	Establishment and validation of predictive model of ARDS in critically ill patients. Journal of translational medicine • 2025-01-14	77.0	8	7	8	7
38	Longitudinal recovery trajectories and ventilatory modalities in COVID-19 acute respiratory distress syndrome survivors. ERJ open research • 2025-04-08	77.0	7	8	8	8
39	Individualized PEEP titration by lung compliance during one-lung ventilation: a meta-analysis. Critical care (London, England) • 2025-01-18	76.5	7	7	9	6
40	Bio-orthogonal-labeled exosomes reveals specific distribution in vivo and provides potential application in ARDS therapy. Biomaterials • 2025-03-03	76.5	9	8	6	9
41	Human lung microvascular endothelial cell protein modification by 2-chlorohexadecanoic acid: RhoA mediates 2-chlorohexadecanoic acid-elicited endothelial activation. Redox biology • 2025-03-22	76.0	9	7	7	7
42	Vasoactive Intestinal Peptide (VIP) in COVID-19 Therapy-Shedding of ACE2 and TMPRSS2 via ADAM10. International journal of molecular sciences • 2025-03-27	76.0	9	7	7	7
43	LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation. Journal of translational medicine • 2025-01-07	76.0	9	8	7	6
44	Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung. Proceedings of the National Academy of Sciences of the United States of America • 2025-03-03	76.0	8	8	7	8
45	Indoleamine 2,3-dioxygenase 1 drives epithelial cells ferroptosis in influenza-induced acute lung injury. Redox biology • 2025-03-03	76.0	9	7	7	7
46	Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients. Frontiers in immunology • 2025-01-30	75.5	7	7	8	8
47	Prognostic Significance of Driving Pressure for Initiation and Maintenance of ECMO in Patients with Severe ARDS: A Systematic Review and Meta-analysis. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine • 2025-03-20	75.5	7	8	8	7
48	Heparan sulfate acts in synergy with tight junction through STAT3 signaling to maintain the endothelial barrier and prevent lung injury development. International immunopharmacology • 2025-01-11	75.5	8	7	8	6
49	Efficacy of tocilizumab for hospitalized patients with COVID-19 pneumonia and high IL-6 levels: A randomized controlled trial. Infection • 2025-04-15	75.5	8	7	8	6
50	Comparative outcomes of corticosteroids, neuromuscular blocking agents, and inhaled nitric oxide in ARDS: a systematic review and network meta-analysis. Frontiers in medicine • 2025-02-18	75.5	7	8	8	7

About Scores

Innovation (0-10)

Degree of novel approaches or discoveries

Impact (0-10)

Potential impact on clinical practice

Rigor (0-10)

Robustness of research methodology

Citation (0-10)

Likelihood of being cited in future research