Daily Cosmetic Research Analysis

BACKGROUND: This randomized controlled trial aimed to investigate the potential benefits of local application of triamcinolone acetonide combined with topical recombinant bovine basic fibroblast growth factor in promoting wound healing and reducing scar formation after circumcision using a stapler device. METHODS: A total of 192 patients with phimosis or redundant prepuce were randomly assigned to either the observation group (n = 96) or the control group (n = 96). Both groups underwent circumcision using a stapler device. Postoperatively, the observation group received wet dressings of 2 mg/mL triamcinolone acetonide solution combined with topical recombinant bovine basic fibroblast growth factor until complete wound healing. The control group received saline wet dressings and standard postoperative wound care. Outcome measures included: postoperative edema, time to resolution of swelling at the incision edges, wound exudate, healing time, staple removal time and rate, scar formation, and patient satisfaction with penile cosmesis. RESULTS: The observation group demonstrated significantly faster healing times and lower incidence of edema from the seventh postoperative day compared to the control group (P < .05). Furthermore, the observation group exhibited superior outcomes in terms of complete staple removal time, staple detachment rate, scar hypertrophy, and cosmetic scores using the modified Stony Brook Scar Evaluation Scale (P < .05). Patient satisfaction with penile cosmesis was also significantly higher in the observation group (P < .05). CONCLUSION: This study underscores the principle of "prevention over treatment" in scar management following stapler circumcision. The findings suggest that the combined use of triamcinolone acetonide and recombinant bovine basic fibroblast growth factor may be beneficial in reducing postoperative edema, improving scar formation, and enhancing patient satisfaction. However, further research is warranted to validate these findings, establish optimal treatment protocols, and ultimately assess the long-term efficacy and safety of this combined therapy.

This study evaluates and compares the results of single-port (SP-RAP) versus multi-port robot-assisted laparoscopic pyeloplasty (MP-RAP) for the treatment of ureteropelvic junction obstruction (UPJO). A systematic review and meta-analysis were conducted following PRISMA guidelines. Studies comparing SP-RAP and MP-RAP for UPJO treatment were identified from PubMed, Web of Science, and Cochrane Library databases. Key outcomes included operative time, hospital stay, and complication rates. Weighted mean differences (WMD) and risk ratios (RR) were calculated using fixed- or random-effects models based on heterogeneity. Statistical significance was set at P < 0.05. Both SP-RAP and MP-RAP demonstrated comparable surgical success rates (SP-RAP: 98.85%, MP-RAP: 98.08%), complication rates, and estimated blood loss. In the adult subgroup, SP-RAP was associated with shorter hospital stays (WMD: -0.52 days; P = 0.04). Postoperative morphine consumption was also lower in the SP-RAP group (WMD: -31.02 mg; P = 0.03), reflecting its minimally invasive nature. However, no significant differences were observed in operative time, pain scores, or renal function recovery between the two groups. Additionally, some studies suggested that SP-RAP may offer better cosmetic outcomes due to its single incision; however, due to the lack of standardized cosmetic satisfaction evaluation criteria, this finding is presented as a potential advantage rather than a definitive conclusion. The SP system demonstrates comparable safety and effectiveness to MP-RAP while offering advantages in cosmetic outcomes and recovery. Further long-term studies are needed to validate its benefits and optimize its application.

OBJECTIVE: To evaluate the efficacy of a plaque-identifying toothpaste in assisting with plaque removal in adolescents undergoing orthodontic treatment with fixed appliances. METHODS: A randomised, double-blind, active-comparator trial was conducted at the Orthodontic Department, University Medical Center Department, University Medical Center Groningen, the Netherlands, from October 2021 to January 2022. Seventy seven healthy adolescents aged 12-16 years, undergoing buccal fixed appliance treatment for at least 3 months, were enrolled. Participants were stratified based on manual or electric brushing habits and randomised to receive either plaque-identifying toothpaste or a non-colouring control toothpaste. The primary outcome measured reduction in dental plaque using Quantitative Light-Induced Fluorescence ∆R30 (QLF) images at baseline (T0) and after 4-7 weeks (T1). Secondary outcomes included self-reported participant experiences. RESULTS: No statistically significant difference in plaque reduction was found between the two groups (F = 0.211, p = 0.647). Subgroup analyses showed that participant-related factors did not significantly influence plaque reduction. Participants using plaque-identifying toothpaste reported a slightly stronger perception of plaque removal (p = 0.018) but encountered slightly more difficulty with the toothpaste colour (p = 0.028). Compliance was high, and no adverse effects were reported. CONCLUSION: Plaque-identifying toothpaste did not lead to significant plaque reduction among adolescents with fixed orthodontic appliances.