Daily Cosmetic Research Analysis
Across cosmetic and aesthetic surgery/dentistry, a PRISMA-compliant meta-analysis shows Dermabond Prineo reduces wound infection and delayed healing while improving scar cosmesis and shortening closure time. A triple-blind RCT supports sodium phytate (0.875%) as a whitening agent with time-dependent efficacy but limited extrinsic stain removal by week 4. A large meta-analysis indicates single-incision cholecystectomy offers cosmetic advantages but slightly worsens pain, wound infection, and leng
Summary
Across cosmetic and aesthetic surgery/dentistry, a PRISMA-compliant meta-analysis shows Dermabond Prineo reduces wound infection and delayed healing while improving scar cosmesis and shortening closure time. A triple-blind RCT supports sodium phytate (0.875%) as a whitening agent with time-dependent efficacy but limited extrinsic stain removal by week 4. A large meta-analysis indicates single-incision cholecystectomy offers cosmetic advantages but slightly worsens pain, wound infection, and length of stay versus conventional multiport surgery.
Research Themes
- Sutureless skin closure and scar optimization
- Evidence-based cosmetic dentistry and whitening agents
- Trade-offs in minimally invasive surgery prioritizing cosmesis
Selected Articles
1. Dermabond Prineo: a systematic review and meta-analysis.
Across abdominoplasty, mammoplasty, and arthroplasty, Dermabond Prineo shortened closure time, reduced wound infection (OR 0.65) and delayed healing (OR 0.42), and improved scar cosmesis versus traditional closure. Evidence on real-world cost-effectiveness remains limited and allergic reactions require monitoring.
Impact: This synthesis provides multi-procedure evidence that a mesh-adhesive system can both improve cosmetic scarring and reduce infections while saving operative time, informing closure choices across surgical specialties.
Clinical Implications: Consider Dermabond Prineo for patients prioritizing scar quality and faster closure, especially in abdominoplasty and mammoplasty, while counseling on rare allergic reactions. Institutions should evaluate real-world cost-effectiveness and establish protocols for appropriate case selection.
Key Findings
- Reduced wound infection vs controls (1.51% vs 2.13%; OR 0.65; p=0.01).
- Reduced delayed wound healing (0.99% vs 1.79%; OR 0.42; p=0.05).
- Consistently shorter application/closure time across studies.
- Improved scar cosmesis/long-term maturation compared with sutures in all studies that assessed it.
- Cost-effectiveness modeling suggested $50–76 savings per patient, but retrospective analysis found no significant hospital cost difference.
Methodological Strengths
- PRISMA-guided systematic review with quantitative meta-analysis.
- Cross-procedure synthesis enhances generalizability of findings.
Limitations
- Mixed study designs and potential heterogeneity/publication bias.
- Real-world cost-effectiveness and allergy incidence not robustly established.
Future Directions: Prospective comparative trials focused on long-term scar quality and cost-effectiveness; standardized reporting of allergic events; subgroup analyses by procedure and patient risk.
OBJECTIVE: Dermabond Prineo (Ethicon Inc., US) is a combination of a skin adhesive applied over a polyester mesh to reinforce and share tension equally over the surgical wound with the aim of reducing closure time and improving wound healing. The aims of this systematic review were to assess published data on Dermabond Prineo regarding infection rates, delayed wound healing, cosmetic appearance and application time compared to conventional wound closure techniques across multiple surgical procedures. METHOD: A literature search was conducted according to PRISMA guidelines. The primary outcome was the incidence of wound infection after Dermabond Prineo compared to controls, namely traditional methods of wound closure such as staples, sutures and adhesives. Secondary outcome measures included allergic reactions and time taken for application. RESULTS: A literature search using PubMed, SCOPUS and Science Direct identified 52 studies, of which 19 were eligible for qualitative synthesis and 12 for meta-analysis. The studies included reflected a broad range of applications of Dermabond Prineo for wound closure in abdominoplasty, mammoplasty and arthroplasty. Overall, all studies reporting on time taken for application found that Dermabond Prineo reduced time for wound closure. Meta-analysis identified a statistically significant reduction in wound infection rates (Dermabond Prineo 1.51%, control 2.13%; OR: 0.65 (0.46, 0.91); p=0.01) and a reduction in delayed wound healing (Dermabond Prineo 0.99%, control 1.79%; OR: 0.42 (0.18, 0.98); p=0.05). All three studies reporting on outcomes of scar cosmesis or long-term maturation attested to improved cosmetic results compared with sutures. The cost-effectiveness of Dermabond Prineo with a hypothetical model was discussed in two studies which concluded that it could achieve savings of $50-76 USD per patient, while a retrospective model found no statistically significant difference in total hospital costs or operating room time. CONCLUSION: In this review, Dermabond Prineo showed lower wound infection rates and a reduction in delayed wound healing. Further studies are required to assess cost-effectiveness in a real-world setting.
2. Whitening efficacy and removal of extrinsic tooth stain of sodium phytate-containing whitening toothpaste: a randomized controlled trial.
In a triple-blind RCT (n=80), 0.875% sodium phytate toothpaste produced significant time-dependent tooth whitening (lower b-values) over 3 weeks versus control. By week 4, extrinsic stain removal benefits were minimal, though participants reported improved aesthetics.
Impact: Provides controlled clinical evidence for sodium phytate as a whitening agent, informing formulation and counseling for cosmetic dentistry and OTC oral care.
Clinical Implications: For patients seeking tooth color improvement, a sodium phytate toothpaste can be recommended for at least 3 weeks to achieve whitening; expectations for extrinsic stain removal by week 4 should be tempered. Objective shade assessment can guide monitoring.
Key Findings
- Triple-blind RCT with 80 participants comparing 0.875% sodium phytate vs control toothpaste.
- Significantly lower b-values (yellowness) in the sodium phytate group over time (p<0.05).
- By week 4, minimal efficacy for removing extrinsic stains based on Lobene Index.
- Improved participant self-assessed tooth color on an aesthetic numerical analogue scale.
Methodological Strengths
- Randomized, triple-blind, controlled design with objective spectrophotometric assessment.
- Pre-specified timepoints (baseline, 2, 3, 4 weeks) and validated stain index.
Limitations
- Single study with modest sample size and 4-week follow-up.
- Incomplete reporting of all colorimetric indices in the abstract and generalizability to diverse populations is uncertain.
Future Directions: Larger, longer RCTs comparing sodium phytate with established whitening agents, mechanistic studies on chelation/anti-stain pathways, and real-world effectiveness in smokers/coffee-tea consumers.
OBJECTIVE: The study aimed to evaluate the whitening efficacy and removal of extrinsic tooth stain of sodium phytate-containing whitening toothpaste, as well as to evaluate participant satisfaction. METHODS: A total of eighty participants were recruited for this randomized, triple-blind controlled trial and were randomly assigned to either the test group (toothpaste containing 0.875% sodium phytate, ST) or the control group (toothpaste without sodium phytate, CT). Tooth color was assessed using a VITA spectrophotometer and changes in exogenous tooth stains were evaluated using the Lobene Index, which were conducted at baseline, as well as at 2, 3, and 4 weeks. Additionally, participants' self-assessment of tooth color were evaluated through an aesthetic numerical analogue scale. Statistical tests were conducted appropriately, and the significance level was established at α = 0.05. RESULTS: This study demonstrates that the b-value of the index teeth in the ST group was significantly lower (p < 0.05) than that of the CT group, while the △WI CONCLUSION: Brushing teeth with sodium phytate-containing whitening toothpaste for a duration of three weeks demonstrates notable whitening effects, which significantly increase over time. However, after four weeks, the sodium phytate-containing toothpaste shows minimal efficacy in removing extrinsic tooth stains. CLINICAL SIGNIFICANCE: Sodium phytate may be incorporated into toothpaste as a whitening agent.
3. Comparing Single-Incision Cholecystectomy and Multiple-Incision Cholecystectomy: A Systematic Review and Meta-Analysis of Postoperative Complications.
PRISMA-guided meta-analysis (51 studies; 2,069 patients) shows SILC trades cosmetic appeal for slightly higher pain, wound infection (OR 1.77), and hospital stay (MD 0.22 days), with no recovery time advantage over conventional multiport cholecystectomy.
Impact: Clarifies safety–cosmesis trade-offs in a common procedure, informing shared decision-making and surgical training pathways for patients prioritizing minimal scarring.
Clinical Implications: When considering SILC for cosmetic reasons, discuss a modestly higher risk of wound infection and pain versus CLC; implement strict infection prevention and careful case selection while pursuing technique refinements.
Key Findings
- Included 51 studies with 2,069 patients under PRISMA framework.
- SILC had higher postoperative pain (MD 0.18; p<0.001).
- SILC increased wound infection risk (OR 1.77; 95% CI 1.30–2.79; p<0.001).
- Slightly longer hospital stay with SILC (MD 0.22 days; p<0.001).
- No significant difference in recovery time (MD 0.01 days; p=0.73).
Methodological Strengths
- Systematic PRISMA process with quantitative synthesis of multiple outcomes.
- Large aggregated sample across diverse centers increases external validity.
Limitations
- Likely heterogeneity in surgical expertise, case mix, and study designs; potential publication bias.
- Cosmetic outcomes were inferred from incision number rather than standardized scar assessments.
Future Directions: Well-controlled RCTs with standardized cosmetic scar scores and core outcome sets; stratification by BMI and comorbidity; technique and instrument refinements to mitigate infections.
Laparoscopic cholecystectomy is the gold standard for managing benign gallbladder disease, with the conventional multiport technique widely practiced. Single-incision laparoscopic cholecystectomy (SILC) has emerged as an alternative, offering potential benefits such as improved cosmetic outcomes, reduced pain, and quicker recovery; however, its efficacy and safety compared to conventional laparoscopic cholecystectomy (CLC) remain unclear. This meta-analysis, which followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, included 51 studies with 2,069 patients to compare clinical outcomes such as postoperative complications, pain, recovery time, and wound infection rates between SILC and CLC. SILC was associated with slightly higher postoperative pain scores (mean difference, 0.18; 95% CI, 0.09-0.27; p < 0.001), increased wound infection rates (OR, 1.77; 95% CI, 1.30-2.79; p < 0.001), and a marginally longer hospital stay (mean difference, 0.22 days; 95% CI, 0.16-0.28; p < 0.001). Recovery time showed no significant difference (mean difference, 0.01 days; 95% CI, -0.56 to 0.59; p = 0.73). While SILC offers a cosmetic advantage due to fewer incisions, it is associated with marginally less favorable clinical outcomes compared to CLC, highlighting the need for further research to assess its long-term efficacy and refined surgical techniques.