Daily Cosmetic Research Analysis

Superfine recycled regenerated silk fibroin (RRSF) monofilament sutures are designed to minimize surgical incisions, prevent scar formation, and facilitate precise suturing in cosmetic and plastic surgeries. However, balancing fineness and strength remains a challenge because the RRSF extraction process disrupts the hierarchical structure of natural silk fibers, leading to suboptimal mechanical properties. This study employed mechanical peeling and grinding to exfoliate β-sheets-rich silk fibroin nanofibrils (SFNF), which served as homologous reinforcing materials uniformly dispersed in the RRSF spinning system. Water-soluble, biocompatible polyvinyl alcohol (PVA) was introduced to enhance ductility. The fiber underwent extensive water immersion stretching to produce ultrafine fibers and foster a highly oriented internal self-reinforcing SFNF network structure. Monofilament surgical sutures were successfully fabricated following surface coating with chitosan. Our results showed that with 0.1 wt% SFNF and a stretching multiplier of 2.5, the tensile strength of the fibers increased by 33 % compared to those without SFNF. Fluorescence staining confirmed the presence of highly oriented SFNF networks within the fibers. Mechanical simulations validated the pronounced reinforcement effect of this network structure. The sutures, measuring 39.38 μm in diameter and exhibiting a tensile strength of 0.31 N, met USP standards for 9-0 surgical sutures, making them suitable for microsurgery. Additionally, they demonstrated antibacterial properties, biocompatibility, and degraded at a rate of 43.09 % within 30 days. In animal trials, the sutures facilitated wound closure, reduced inflammatory responses, and minimized scar formation.

BACKGROUND: Venous thromboembolism (VTE) is a rare complication following rhinoplasty surgery, with an occurrence rate generally estimated to be between 0.5% and 1%. In contrast, the occurrence rate of VTE in orthopedic surgeries, particularly in lower limb fracture surgeries, can reach as high as 10% or more. This significant difference highlights the varying risks associated with different surgical procedures and underscores the importance of identifying risk factors specific to rhinoplasty. Despite its relatively low incidence, the potential for VTE in rhinoplasty patients necessitates a thorough analysis of risk factors to enhance patient safety and guide clinical practice. This study aims to analyze the risk factors for postoperative VTE in rhinoplasty patients and develop a predictive model to assist clinicians in identifying at-risk individuals. METHODS: A retrospective analysis was conducted on the clinical data of 1100 rhinoplasty patients admitted to a cosmetic hospital from January 2016 to January 2022. Patients were divided into Non-VTE group (1012 cases) and VTE group (88 cases) based on the occurrence of VTE within one month postoperatively. General patient information was collected and subjected to univariate analysis. Multivariate logistic regression analysis was used to identify risk factors for postoperative VTE in rhinoplasty patients and establish a predictive model. Internal validation was performed using bootstrapping technique to assess the accuracy and predictive performance of the model. RESULTS: Univariate analysis showed that the proportions of IBD, Myocardial infarction, Previous VTE, PICC/central line, Rib graft, and History of nasal surgery were significantly higher in the VTE group compared to the Non-VTE group (all P < 0.05). Multivariate logistic regression analysis identified IBD, Myocardial infarction, Previous VTE, Rib graft, and History of nasal surgery as independent risk factors for VTE (P < 0.05). The constructed predictive nomogram model demonstrated good calibration and predictive accuracy, with an area under the ROC curve of 0.845, indicating excellent discrimination and clinical predictive performance. CONCLUSION: IBD, Myocardial infarction, Previous VTE, Rib graft, and History of nasal surgery are independent risk factors for postoperative VTE in rhinoplasty patients. The predictive model effectively assesses the risk of VTE in patients, providing important guidance for clinical decision-making.

BACKGROUND: Since the introduction of glabellar contraction patterns as a guide for neuromodulator treatments, feedback regarding its clinical utility has been mixed. Recent studies have cast doubt on the value of such contraction-pattern-driven treatment paradigms. OBJECTIVE: The aim of this retrospective study is to evaluate the clinical outcome of identical glabellar injections independent of glabellar contraction pattern types. METHODS: Forty-two Brazilian, multi-ethnic, consecutive patients with moderate to very severe glabellar lines were included in this retrospective analysis. The same 3-point glabellar injection technique was utilized, administering a total of 37.5 sU (=15 IU) to the procerus and corrugator supercilii muscles. Glabellar severity was assessed at 20 and 90 days after the initial treatment. RESULTS: Across the entire study sample, a highly statistically significant improvement was observed at all investigated follow-up time points (p < 0.001). When comparing the treatment outcome across the five different glabellar contraction patterns, there was no statistically significant difference detected at either 20 days follow-up (p = 0.373) or 90 days follow-up (p = 0.311). Multivariate analyses confirmed that neither age, BMI, Fitzpatrick skin type, nor glabellar contraction patterns statistically influenced the outcome at 90 days (all p > 0.05). CONCLUSION: The results of this retrospective analysis revealed that in the sample investigated, no statistically significant differences were detected between patients with different glabellar contraction patterns at any of the conducted follow-up visits when the same glabellar injection technique with the same amount of toxin units was administered.