Daily Cosmetic Research Analysis

PURPOSE: The majority of patients with breast cancer are treated with breast-conserving surgery followed by postoperative whole or partial breast irradiation (PBI). Previous studies on PBI demonstrated similar ipsilateral breast tumor recurrences compared with whole breast irradiation, however, conflicting data on toxicity and cosmetic outcomes were reported. This study investigates the feasibility of stereotactic magnetic resonance imaging-guided adaptive radiation therapy (SMART) for PBI, with emphasis on toxicity and cosmetic outcomes. METHODS AND MATERIALS: Patients with low-risk breast cancer suitable for PBI as defined by European Society for Radiotherapy and Oncology guidelines were included. SMART was delivered in supine position in a 2-week course of 5 fractions of 6 Gy, or 6.5 Gy in case of high risk characteristics. Patient- and physician-reported toxicity and cosmetic outcomes were scored at 3, 9, 18, and 36 months postoperatively. RESULTS: Between 2017 and 2020, 50 patients were included and 45 patients were treated with SMART. Median age was 66 years, median tumor size was 1.2 cm. Most tumors were Bloom Richardson grade 1 (55.6%) and estrogen receptor positive (95.6%). The majority did not receive adjuvant systemic therapy (80%). The highest grade acute toxicity was grade 2 in 20%, mostly fatigue. At 18 months, 4 patients (9%) reported grade 2 toxicity, consisting of fibrosis and fatigue. No grade ≥3 toxicity was recorded. At 9 and 18 months, 86.4% of patients were (very) satisfied with the cosmetic outcome. The cosmetic outcome was good-excellent compared with the contralateral breast at 18 months in 90.9% and 73.8% as scored by patients and physicians, respectively. CONCLUSIONS: Stereotactic magnetic resonance imaging-guided adaptive PBI for patients with low-risk breast cancer was feasible and resulted in low rates of toxicity. Good cosmetic outcomes were reported by patients after a follow-up of 18 months.

To evaluate the clinical efficacy, advantages, and disadvantages of the modified Shiraki procedure and the transverse pedicled island flap phalloplasty in treating severe concealed penis in children. This study included seventy children with severe concealed penis treated at Yulin First People's Hospital from June 2021 to January 2024. They were randomly assigned to either the observation group (n = 35), undergoing the modified Shiraki procedure, or the control group (n = 35), receiving the transverse pedicled island flap phalloplasty. We assessed average operation time, intraoperative blood loss, penile elongation, time until resolution of penile prepuce edema, flap infection or necrosis, penile erectile pain, prepuce skin redundancy, penile retraction, and overall penile appearance score six months postoperatively. The observation group showed significantly better average operative time and intraoperative blood loss compared to the control group (p < 0.05). The time for foreskin edema to regress was longer in the observation group (p < 0.05). No significant differences were noted in penile lengthening between groups (p > 0.05). The observation group had seven cases of refractory inner prepuce plate swelling and skin redundancy post-operation; two of these cases required secondary surgery, and without skin flap infection or necrosis. The control group reported one case of postoperative hemorrhage and four cases of infection and necrosis of the transferred flap, all resolved after prolonged dressing changes, with one case requiring surgical correction for scar contracture on the side of the penis. Neither group experienced penile erectile pain or retraction. Total complications and reoperations were similar between the groups. No significant difference in the overall penile appearance score was observed between the two groups six months post-surgery (p > 0.05). Both the modified Shiraki procedure and the transverse pedicled island flap phalloplasty are effective for treating severe concealed penis in children. The former is characterized by shorter, simpler operations, while the latter offers better cosmetic outcomes despite its complexity.

Nociception is a critical biological process that facilitates detecting and avoiding harmful stimuli. Methylisothiazolinone (MIT) and methylchloroisothiazolinone (CMIT) are biocidal agents widely used in disinfectants and cosmetics, however, their effects on nociceptive pathways and neurotoxicity remain insufficiently understood. This study investigated the neurotoxic and nociceptive effects of CMIT/MIT mixtures in zebrafish models. Zebrafish embryos were exposed to CMIT/MIT, and their behavioral and molecular responses to nociceptive stimuli were assessed. Acute exposure (4 -72 h post-fertilization) to CMIT/MIT (15 and 30 μg/L) led to heightened behavioral responses to noxious stimuli, significantly increasing velocity and neuronal activity. Molecular analysis revealed the upregulated expression of nociception-related and inflammatory markers. Subchronic exposure (4 hpf to 28 days post-fertilization) to lower CMIT/MIT concentrations resulted in prolonged freezing responses and reduced the movement in zebrafish larvae. Protein-protein interaction analysis further identified key pathways, including calcium signaling, MAPK, and neuroinflammation, affected by CMIT/MIT exposure. This study provides evidence that even low levels of CMIT/MIT exposure can enhance nociceptive responses by activating sensory neurons and modulating inflammatory pathways, raising concerns about the neurotoxic potential of these widely used biocidal compounds.