Daily Cosmetic Research Analysis
Consensus protocols for pin-based fractional radiofrequency provide practical, device-specific guidance for resurfacing common aesthetic concerns. A prospective pilot suggests glabellar-only neuromodulator injections can progressively improve forehead rhytids by rebalancing facial muscle dynamics. In oncoplastic surgery, intraoperative ICG angiography offers rapid perfusion assessment of chest wall perforator flaps, correlating with favorable cosmetic outcomes.
Summary
Consensus protocols for pin-based fractional radiofrequency provide practical, device-specific guidance for resurfacing common aesthetic concerns. A prospective pilot suggests glabellar-only neuromodulator injections can progressively improve forehead rhytids by rebalancing facial muscle dynamics. In oncoplastic surgery, intraoperative ICG angiography offers rapid perfusion assessment of chest wall perforator flaps, correlating with favorable cosmetic outcomes.
Research Themes
- Energy-based skin resurfacing protocols
- Neuromodulator biomechanics and injection strategy
- Intraoperative perfusion imaging in oncoplastic reconstruction
Selected Articles
1. Pin-Based Fractional Radiofrequency: 2024 International Consensus Recommendations for Aesthetic Skin Indications.
An international expert panel used a modified Delphi process to standardize pin-based fractional RF protocols for acne scars, enlarged pores, texture irregularities, rhytides, and striae. The recommendations specify device parameters by indication and Fitzpatrick type, as well as patient preparation, anesthesia, and aftercare, positioning pFRF as a well-tolerated alternative to lasers and RF microneedling.
Impact: Provides actionable, consensus-based, device-specific parameters that can immediately standardize and improve safety and outcomes in aesthetic resurfacing across skin types.
Clinical Implications: Offers starting parameters and workflows for new adopters of pFRF, supports safer treatment in skin of color by tailoring energy and density, and may reduce downtime and complications versus lasers.
Key Findings
- Standardized pFRF protocols were defined for acne scars, enlarged pores, texture, rhytides, and striae.
- Device parameters, patient preparation, anesthesia, and post-care are specified, including adjustments by Fitzpatrick skin type and condition severity.
- Panel consensus positions pin-based RF (without microneedles) as a practical alternative to fractional lasers and RF microneedling with good tolerability.
Methodological Strengths
- Modified Delphi consensus with an international, multidisciplinary expert panel
- Detailed, indication-specific operational parameters and workflows
Limitations
- Consensus-based guidance without randomized comparative outcome data
- Recommendations may be device-specific and not universally generalizable
Future Directions: Prospective comparative trials versus fractional lasers and RF microneedling across Fitzpatrick IV–VI; long-term safety, efficacy, and patient-reported outcomes.
BACKGROUND AND OBJECTIVE: Fractional radiofrequency was developed as a potentially lower-risk and downtime alternative to traditional fractional ablative and nonablative lasers for skin resurfacing. Pin-based FRF (pFRF) delivers radiofrequency heat in focal, high-energy density columns within intact skin, without microneedle insertion. The main objective of this publication was to get an expert consensus on best-in-practice protocols for treating common aesthetic indications for resurfacing using a novel pFRF device. METHODS: An international panel of 10 dermatologists and plastic and reconstructive surgeons from 6 countries and a variety of practice settings was assembled to develop updated consensus recommendations for using pFRF. A modified Delphi method included: a preliminary questionnaire, video conference roundtable discussion, individual review of initial data, a secondary questionnaire, and multiple rounds of email discussion until a group consensus was reached. RESULTS: The panel developed standardized pFRF protocols for the treatment of acne scars, enlarged pores, skin texture, rhytides, and striae. For each diagnosis, device parameters and techniques are outlined. General requirements for patient preparation, anesthesia, and post-treatment care are described. Special consideration was given to device settings for condition severity and Fitzpatrick skin type. These guidelines are meant to provide new practitioners with a starting point for safe and effective patient treatment. CONCLUSIONS: pFRF without microneedles is a useful alternative to fractional laser technology and radiofrequency microneedling for resurfacing patients’ skin texture irregularities. Patients tolerate the procedure and recovery well. Here, protocols for the treatment of 5 common aesthetic skin complaints with a novel pFRF device are provided.
2. Continuous Improvement of Frontal Rhytids Following Glabella Only Treatments With Neuromodulators-A Clinical Prospective Pilot Study.
In a 7-month prospective pilot (n=18), abobotulinumtoxinA injected only into the glabella improved forehead wrinkle severity (FWS 3.0 to 1.0) and reduced frontal skin displacement without changing eyebrow position. Findings support a biomechanics-based approach that may lower risks associated with frontalis injections.
Impact: Introduces a potentially safer injection strategy that achieves forehead rejuvenation by altering muscle balance, which could reduce brow ptosis risk and simplify treatment planning.
Clinical Implications: Consider glabellar-only dosing for patients at risk of brow descent or where frontalis dosing is undesirable, with scheduled maintenance to leverage progressive improvement.
Key Findings
- GLSS improved from 3.0 at baseline to 1.0 after the third cycle (p<0.001).
- Forehead Wrinkle Scale improved from 3.0 to 1.0 after three cycles (p=0.005).
- Frontal Skin Displacement decreased from 37.2 mm to 17.9 mm (p<0.01) with no change in eyebrow position (EPS).
Methodological Strengths
- Prospective interventional design with repeated assessments over three treatment cycles
- Use of multiple objective and validated measures (GLSS, FWS, FSD, EPS)
Limitations
- Small sample size (n=18) and no control or comparator arm
- Single neuromodulator type and fixed dosing may limit generalizability
Future Directions: Randomized controlled trials comparing glabellar-only versus combined glabellar–frontalis strategies, with electromyography and biomechanical mapping to elucidate mechanisms.
INTRODUCTION: While traditionally focused on treating glabellar and forehead rhytids through direct neuromodulator injections, recent findings on the biomechanics of facial muscles suggest that glabellar treatments alone may influence forehead wrinkles by altering the dynamic balance between depressor and elevator muscles. OBJECTIVE: To evaluate whether glabellar-only neuromodulator treatments can reduce forehead wrinkle severity without direct injections into the frontalis muscle. METHODS: This prospective, interventional study included 18 participants with moderate to very severe glabellar lines. Neuromodulator (AbobotulinumtoxinA; 37.5 sU (= 15 IU)) injections were administered exclusively in the glabella at three intervals over 7 months. Glabellar Severity Scale (GLSS), Forehead Wrinkle Scale (FWS), Frontal Skin Displacement (FSD), and Eyebrow Position Scoring (EPS) were assessed at baseline and 30 days after each cycle. RESULTS: GLSS scores significantly improved across treatment cycles (baseline: 3.0; post-third cycle: 1.0; p < 0.001). FWS improved from 3.0 at baseline to 1.0 after the third cycle (p = 0.005), while FSD showed a significant reduction from 37.2 mm to 17.9 mm (p < 0.01). No changes in eyebrow position were detected following EPS assessment. CONCLUSION: Glabellar-only neuromodulator treatments with 37.5 sU (= 15 IU) effectively reduced forehead rhytid severity, likely by altering the balance between depressor and elevator muscles. This approach minimizes risks associated with direct frontalis injections and offers a novel strategy for forehead rejuvenation. Moreover, the observed progressive improvement across treatment cycles suggests that this strategy may continuously enhance aesthetic outcomes over time, supporting the rationale for maintenance treatments at regular intervals.
3. Implication of indocyanine green angiography for chest wall perforator flap reconstruction in breast-conserving surgery.
In a retrospective series of 22 BCS patients undergoing CWPF reconstruction, intraoperative ICG angiography visualized perforators and assessed flap perfusion within 20–110 seconds, typically under two minutes. Simultaneous perfusion of flap and adjacent tissue (88%) and shorter perfusion times correlated with favorable outcomes, supporting ICG-guided perforator selection and perfusion assessment.
Impact: Demonstrates practical intraoperative perfusion metrics that can inform perforator selection and potentially reduce complications, improving aesthetic outcomes in oncoplastic reconstruction.
Clinical Implications: Adopting ICG angiography for CWPF may help target perfusion times under two minutes and confirm simultaneous perfusion of adjacent tissues, guiding intraoperative decisions to optimize flap viability and cosmesis.
Key Findings
- ICG angiography was used in 21 of 22 flaps, with perfusion completion within 20–110 seconds, typically <2 minutes.
- Most cases had two perforators identified by ICG; 88% showed simultaneous perfusion of flap and adjacent tissue.
- Perfusion onset time differed between flaps supplied by single versus multiple perforators, informing intraoperative decisions.
Methodological Strengths
- Real-world consecutive surgical series with objective perfusion timing using ICG
- Inclusion of multiple CWPF types (AICAP, LICAP±LTAP, TDAP) increases practical generalizability
Limitations
- Retrospective single-center study with small sample size (n=22)
- Lack of standardized aesthetic outcome scales and control group limits causal inference
Future Directions: Prospective studies correlating quantitative ICG metrics with necrosis rates, revisions, cosmetic scores, and patient-reported outcomes; cost-effectiveness analyses.
BACKGROUND: Volume replacement after breast-conserving surgery (BCS) can help achieve a good cosmetic outcome, especially in patients with small breast size, where volume displacement is limited. Latissimus dorsi myocutaneous flaps, which are widely used, require a longer hospital stay and have a risk of donor site morbidity. Chest wall perforator flap (CWPF) could be used as an alternative option. Although this has the advantage of a shorter hospital stay and muscle preservation, the dissection of perforator vessels is required. Using indocyanine green (ICG) intraoperatively can help the surgeon to visualize the perforators and assess the flap perfusion. Our study aimed to examine the roles of these techniques for CWPF reconstruction in BCS. METHODS: We retrospectively reviewed 22 patients who underwent CWPF reconstruction at the Queen Sirikit Centre for Breast Cancer, King Chulalongkorn Memorial Hospital from January 2023 to October 2024. Patients' baseline characteristics, types of CWPF, number of perforators identified by ICG and by direct visualization, complications, and perfusion time of ICG were reviewed. RESULTS: Eight patients had anterior intercostal artery perforator (AICAP) flap reconstruction. Thirteen patients had lateral intercostal arterial perforator (LICAP) flap reconstruction with or without lateral thoracic arterial perforator (LTAP) flap reconstruction. One patient had thoracodorsal arterial perforator (TDAP) reconstruction. The ICG was used in 21 flaps. ICG perfusion was completed within 2 minutes (range, 20-110 seconds). Most of the patients had two perforators identified by ICG. In 88% of cases, ICG perfusion of the perforator flap and adjacent normal tissue was visualized simultaneously. There was a difference in ICG perfusion onset time between flaps with one versus multiple perforators. CONCLUSIONS: ICG angiography can be used intraoperatively for flap assessment with helpful information. A perfusion time of less than 2 minutes was correlated with a good clinical outcome. Intraoperative ICG angiography can guide surgeons in evaluating flap perfusion, which can help address both immediate and long-term morbidity concerns.