Daily Cosmetic Research Analysis
Analyzed 11 papers and selected 3 impactful papers.
Summary
A PRISMA-compliant systematic review synthesizes preclinical and limited clinical evidence supporting cellular therapies for trigeminal neuralgia. A retrospective cohort shows thoracoareolar endoscopic thyroidectomy yields comparable oncologic safety to open surgery with better recovery and quality of life, while a systematic review of DIY toothpaste recipes highlights widespread fluoride omission and potential oral health risks.
Research Themes
- Regenerative and cellular therapies for neuropathic pain
- Cosmetic-sparing oncologic surgery and patient-centered outcomes
- Consumer-driven hygiene products and preventive dentistry
Selected Articles
1. The use of cellular therapies for trigeminal neuralgia: a systematic review of behavioral and molecular outcomes.
This PRISMA-based systematic review (7 preclinical, 1 clinical report) found that cellular therapies (SHED, OECs, BMSCs) consistently improved pain behaviors in TN models and modulated myelin repair and neuroinflammation. An incidental clinical case using ADSCs during a facial cosmetic procedure remained pain-free at 2 years, underscoring translational potential but highlighting the need for rigorous trials.
Impact: It integrates behavioral and molecular outcomes across multiple cell platforms, defining mechanistic rationales and a translational pathway for regenerative therapies in TN.
Clinical Implications: While not practice-changing yet, the synthesis supports designing early-phase trials (dose, delivery route, safety endpoints) for cell therapies in TN and informs patient selection.
Key Findings
- Eight studies (7 preclinical, 1 clinical) met PRISMA criteria for cellular therapies in TN.
- All preclinical studies demonstrated significant behavioral pain improvement vs controls (p<0.05).
- Proposed mechanisms included myelin repair promotion, neuroinflammation reduction, and modulation of pain pathways.
- Single clinical report: incidental ADSC use during a facial cosmetic procedure resulted in 2-year pain freedom.
Methodological Strengths
- PRISMA-compliant systematic search and selection.
- Integration of behavioral and molecular readouts across diverse cell types (SHED, OECs, BMSCs).
Limitations
- Predominantly preclinical evidence with only one clinical case.
- Heterogeneity in models, cell sources, doses, and delivery routes limits meta-analytic synthesis.
Future Directions: Standardize TN models and outcome measures, optimize cell sources/dosing/delivery, and initiate controlled phase I/II trials to establish safety and preliminary efficacy.
Trigeminal neuralgia (TN) is a neuropathic pain disorder characterized by severe orofacial pain. The underlying pathophysiological nuances remain under study, and their understanding is key to developing new and more effective therapies for this debilitating disease. The field of cellular therapies for neurological diseases is continuously evolving. This systematic review was performed after the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We sought studies on the preclinical and clinical uses of cellular therapies for trigeminal neuralgia. We included 8 studies encompassing 1 clinical and 7 preclinical applications. Of the preclinical studies, four used Stem Cells from Human Exfoliated Deciduous Teeth (SHED), two used Olfactory Ensheathing Cells (OECs), and one used Bone Marrow Mesenchymal Stem Cells (BMSCs). All preclinical studies showed a statistically significant behavioral improvement in groups receiving cellular therapies compared to controls (p < 0.05), with either local or systemic delivery. In addition, cellular therapies have the potential to mitigate TN by promoting myelin repair, reducing neuroinflammation, and modulating pain-related pathways. The only clinical report in the literature described the incidental use of Adipose-Derived Stem Cells (ADSCs) during a facial cosmetic procedure in a 60-year-old female with a long history of TN, who remained pain-free at 2-year follow-up. These findings highlight the promising role of cellular therapies in the treatment of TN, demonstrating significant behavioral and molecular benefits in preclinical models and a compelling clinical case. Further rigorous clinical studies are necessary to establish their safety, efficacy, and long-term therapeutic impact.
2. Clinical comparative analysis of endoscopic thyroidectomy via the thoracoareolar approach versus open surgery for the treatment of differentiated thyroid cancer.
In 150 patients with differentiated thyroid carcinoma, thoracoareolar endoscopic thyroidectomy had longer operative time but less blood loss, shorter incisions, earlier extubation, shorter hospital stay, lower pain, and higher QOL, with no significant differences in complications or recurrence up to 24 months versus open surgery. Findings support oncologic safety with cosmetic and recovery advantages.
Impact: Provides comparative oncologic and patient-reported outcomes supporting a cosmetic-sparing approach without compromising short-term cancer control.
Clinical Implications: Thoracoareolar ET can be offered to appropriately selected DTC patients—especially younger individuals prioritizing cosmetic outcomes—with counseling on longer operative time but improved recovery and QOL.
Key Findings
- Retrospective single-center cohort of 150 DTC patients (ET n=70; OT n=80) with comparable baseline characteristics.
- ET had longer operative time but less intraoperative blood loss and shorter incisions.
- ET showed earlier extubation, shorter length of stay, and lower postoperative pain.
- No significant differences in complications or local/distant recurrence over 12–24 months.
- Quality-of-life (QLQ-C30) scores were significantly higher in the ET group.
Methodological Strengths
- Comparability of baseline characteristics between groups.
- Comprehensive outcome assessment including perioperative metrics, complications, recurrence, and QOL.
Limitations
- Retrospective, single-center design with potential selection bias.
- Follow-up limited to 12–24 months; long-term oncologic equivalence remains to be confirmed.
Future Directions: Prospective multicenter studies, ideally randomized, with longer follow-up and cost-effectiveness analyses to validate long-term oncologic safety and patient-centered benefits.
The incidence of differentiated thyroid carcinoma has risen steadily in recent years, making it the most common thyroid malignancy. Surgical resection remains the primary treatment, but conventional open thyroidectomy (OT), while effective, often leaves prominent cervical scars that negatively affect aesthetics and quality-of-life. Endoscopic thyroidectomy (ET) via the thoracoareolar approach has been increasingly adopted, offering improved cosmetic outcomes and faster recovery, although evidence regarding its perioperative performance, complications, and follow-up outcomes remains limited. In this single-center retrospective cohort study, 150 patients with differentiated thyroid carcinoma treated between January 2020 and August 2023 were analyzed, including 70 who underwent ET and 80 who underwent OT. Baseline characteristics were comparable between groups. ET was associated with longer operative time but less intraoperative blood loss, shorter incisions, and more favorable postoperative recovery parameters, including earlier extubation, reduced hospital stay, and lower pain scores. Complication rates and the incidence of local recurrence or distant metastasis over 12 to 24 months did not differ significantly between groups, whereas quality-of-life scores (QLQ-C30) were significantly higher in the ET group. These findings suggest that thoracoareolar ET provides oncologic safety comparable to OT while conferring advantages in minimizing surgical trauma, accelerating recovery, and improving quality of life. ET may be particularly suitable for younger patients with greater cosmetic concerns, and further multicenter prospective studies are warranted to confirm its long-term efficacy and cost-effectiveness.
3. Homemade toothpastes: what recipes for what effects?
A dual systematic effort identified 116 online DIY toothpaste recipes (none containing fluoride) and only six scientific articles on the topic. The work underscores potential harms and knowledge gaps, calling for clinician and patient awareness and rigorous evaluation of efficacy and safety.
Impact: By revealing widespread fluoride omission in DIY toothpastes, it highlights a preventable public health risk and guides dental counseling and policy.
Clinical Implications: Clinicians should advise against DIY toothpaste use, reinforce fluoride’s role in caries prevention, and educate patients on evidence-based oral hygiene.
Key Findings
- Systematic online capture identified 116 distinct DIY toothpaste recipes over 10 years.
- No recipe included fluoride; each used 2–11 ingredients.
- Only six peer-reviewed articles addressed DIY toothpaste, indicating limited scientific evaluation.
- Authors conclude DIY toothpaste may have deleterious effects and requires further study and public education.
Methodological Strengths
- Systematic, multi-browser search strategy with defined time horizon.
- Complementary systematic literature review across five databases.
Limitations
- Online recipes are not validated formulations and may be subject to selection and publication bias.
- No direct clinical outcome data on efficacy or safety.
Future Directions: Conduct controlled studies comparing DIY vs commercial fluoride toothpastes on enamel remineralization, plaque, and caries outcomes; evaluate regulatory and labeling strategies.
Introduction Nowadays, mistrust of industrial products has led to the growing popularity for homemade (or do-it-yourself [DIY]) products, specifically in the field of cosmetics and hygiene products such as toothpastes.Aims The aim of the present work was to complete the data collection by systematically reviewing DIY toothpaste (DIYT) recipes found online and gather information on composition, measurement units and conservation modalities. Furthermore, a systematic literature review on DIYT was performed.Methods Four browsers (Baidu, Ecosia, Google, Yahoo) were used to systematically collect DIYT recipes online over the last ten years; for the systematic review, five scientific databases (Cochrane Library electronic, Embase, Google Scholar, PubMed/Medline, Web of Science) were searched (September 2024) with 'homemade toothpaste recipes' and 'homemade toothpaste' as keywords.Results A total of 116 different DIYT recipes and six articles were found over the last ten years. Between 2-11 different ingredients were considered per recipe. None of the recipes contained fluoride. The literature synthesis showed that further research is needed to document DIYT effects, risks and limitations.Conclusions DIYT may have deleterious effects; dental professionals should be sensitised as well as patients.