Serine-modified silver nanoparticle porous spray membrane: A novel approach to wound infection prevention and inflammation reduction.

Summary

A nanocellulose-based spray film with L-serine-modified AgNPs rapidly forms a transparent, breathable, removable membrane with strong antimicrobial and anti-inflammatory activity. In mice, the formulation improved wound healing metrics and reduced inflammatory markers, suggesting utility for clinical wound care and post-laser cosmetic recovery.

Key Findings

• Developed a transparent, rapidly forming spray film combining nanocellulose and L-serine-modified silver nanoparticles.
• Porous structure enhanced air permeability and drug-carrying capacity while maintaining antimicrobial and anti-inflammatory efficacy.
• In mice, treatment improved wound healing, normalized keratin thickness, increased hair follicle counts, and reduced inflammatory markers.

Clinical Implications

Could reduce infection risk and downtime after dermatologic procedures (e.g., lasers), offering breathable protection and potential anti-inflammatory benefits in outpatient wound care.

Limitations

• No human clinical data; safety profile of repeated AgNP exposure on skin not established
• Dose, application frequency, and long-term biocompatibility/microbiome effects remain uncharacterized

Future Directions

Conduct dermal toxicity and sensitization studies, assess microbiome effects, and perform controlled clinical trials in post-procedure dermatology settings.