Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin.
Summary
This paper establishes the first scalable, high-yield (>40%) and high-purity (>95% without chromatography) synthesis of δ-cyclodextrin (nine glucose units) using enzyme-mediated dynamic combinatorial chemistry and a dodecaborate template. The method enables multigram production, unlocking applications in cosmetics and pharmaceuticals for encapsulating actives, improving stability, and controlled release.
Key Findings
- Introduces a scalable synthesis of δ-cyclodextrin with >40% yield and >95% purity without chromatography
- Achieves multigram quantities using enzyme-mediated dynamic combinatorial chemistry and a dodecaborate template
- Positions δ-CD for applications as a host carrier in foods, cosmetics, and pharmaceuticals
Clinical Implications
While not a clinical study, δ-cyclodextrin may enable safer and more effective topical/cosmeceutical products via improved solubilization and stabilization of active ingredients; toxicology and dermal safety testing will be required before clinical use.
Why It Matters
By overcoming a long-standing scalability barrier, this work provides a foundational excipient platform with direct translational potential in cosmeceutical and pharmaceutical formulation science.
Limitations
- Lacks pharmacokinetic/toxicological data for dermal or systemic exposure
- Industrial cost and environmental impact of the superchaotropic template are not evaluated
Future Directions
Evaluate δ-CD toxicology, dermal compatibility, and performance as a carrier for cosmetic actives; scale-up beyond multigram and lifecycle assessments to support regulatory adoption.
Study Information
- Study Type
- Case series
- Research Domain
- Pathophysiology
- Evidence Level
- V - Laboratory synthesis/chemical methodology; preclinical foundational evidence
- Study Design
- OTHER