Diluted Calcium Hydroxylapatite Carboxymethylcellulose (Radiesse) for Décolleté Wrinkles: Safety and Effectiveness in Adult Females.

Summary

In a randomized immediate-versus-delayed design with blinded assessors, diluted CaHA-CMC (Radiesse) produced a 71.2% responder rate at 24 weeks versus 6.3% in controls, with mostly mild injection-site reactions and no interference on post-treatment breast imaging. Findings support a nonpermanent injectable option for décolleté rejuvenation.

Key Findings

• Responder rate at 24 weeks was 71.2% with diluted CaHA-CMC versus 6.3% in untreated controls.
• Adverse events were predominantly transient, mild-to-moderate injection-site reactions.
• Post-treatment radiographic breast imaging showed no interference attributable to the filler.

Clinical Implications

Supports offering diluted CaHA-CMC as a nonpermanent option for moderate-to-severe décolleté wrinkles, with counseling on expected benefits, transient local reactions, and no anticipated interference with breast imaging.

Limitations

• Primary endpoint at 24 weeks limits longer-term durability assessment.
• Female-only population; total sample size not specified in the abstract.

Future Directions

Conduct longer-term, head-to-head trials versus alternative fillers and dosing strategies, with standardized imaging and patient-reported outcomes for durability and safety.