In Situ Coenzyme-Based Transformable Polymers Powder With Instant-Tough-Adhesive Properties for Emergency Hemostasis, Antibiosis, and Wound Repair.

Summary

A water-activated coenzyme-based coacervate powder instantly gels and strongly adheres to wet tissues, achieving sub-20-second hemostasis across multiple animal bleeding models while surpassing commercial hemostats. It also exhibits broad-spectrum antibacterial and anti-biofilm activity, promotes angiogenesis, and accelerates healing of full-thickness skin defects, highlighting translational potential for surgical and emergency wound care.

Key Findings

• Ultra-rapid self-gelation on hydration (<10 s) with strong wet-tissue adhesion (69.55 kPa) and high burst pressure (216.23 mmHg).
• Achieved hemostasis in <20 s across arterial, tail, and non-compressible visceral bleeding (liver, spleen, heart) with no rebleeding, outperforming commercial hemostats.
• Demonstrated broad-spectrum antibacterial/anti-biofilm activity, pro-angiogenic effects, and accelerated healing in full-thickness skin defects.

Clinical Implications

If validated in humans, this powder could offer rapid, suture-sparing hemostasis and infection mitigation in aesthetic and reconstructive procedures, potentially reducing operative time, complications, and scarring, especially in wet or irregular wounds.

Limitations

• Preclinical animal data; no human clinical outcomes or long-term degradation/scar profiling reported.
• Comparative effectiveness versus standard sutures/sealants beyond commercial hemostats remains to be established.

Future Directions

Conduct first-in-human safety and feasibility studies, head-to-head trials versus standard closure methods, and long-term biocompatibility/scar quality assessments across surgical indications.