adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue.
Summary
This paper introduces a curated portal that unifies clinical and experimental adipose tissue datasets, including multi-depot, cell-type, and perturbation studies, with transcriptomic/proteomic layers from over 6,000 individuals. It streamlines access and enables integrative, single-cell–level analyses, providing a foundational resource for adipose biology and metabolic disease research.
Key Findings
- Centralizes and integrates clinical and experimental adipose datasets with transcriptomic/proteomic data from >6,000 individuals.
- Covers multiple adipose depots, resident cell types, and adipocyte perturbation studies.
- Enables streamlined access for integrative analyses down to the single-cell level.
Clinical Implications
While not directly altering care, the portal can speed translation by enabling robust cross-study validation of adipose biomarkers and therapeutic targets for obesity, insulin resistance, and related disorders.
Why It Matters
Provides a widely usable data infrastructure that can accelerate discovery of mechanisms, biomarkers, and targets across obesity and metabolic disease research.
Limitations
- Scientific insights depend on the heterogeneity and quality of contributing datasets.
- Clinical impact is indirect and contingent on community adoption and continuous updates.
Future Directions
Expand longitudinal and interventional datasets, harmonize metadata, and embed analytic tools to facilitate hypothesis testing and clinical translation.
Study Information
- Study Type
- Cohort
- Research Domain
- Pathophysiology
- Evidence Level
- V - Methods/resource paper integrating existing datasets; indirect clinical evidence.
- Study Design
- OTHER