Endocrinology - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper Title	Total	Innovation	Impact	Rigor	Citation
1	Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science (New York, N.Y.) • 2025-01-17	93.0	10	9	9	9
2	Regulation of mammalian cellular metabolism by endogenous cyanide production. Nature metabolism • 2025-03-04	93.0	10	9	9	9
3	A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1. Nature communications • 2025-12-05	93.0	10	9	9	9
4	Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting. Nature communications • 2025-02-04	90.0	9	9	9	9
5	A comprehensive spatio-cellular map of the human hypothalamus. Nature • 2025-02-06	90.0	9	9	9	9
6	GDF15 links adipose tissue lipolysis with anxiety. Nature metabolism • 2025-04-16	90.0	9	9	9	9
7	G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells. Science translational medicine • 2025-01-02	90.0	9	9	9	9
8	The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite. Cell host & microbe • 2025-01-10	90.0	9	9	9	9
9	Disrupted minor intron splicing activates reductive carboxylation-mediated lipogenesis to drive metabolic dysfunction-associated steatotic liver disease progression. The Journal of clinical investigation • 2025-03-18	90.0	9	9	9	9
10	Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis. Science (New York, N.Y.) • 2025-01-17	90.0	9	9	9	9
11	Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism. Cell metabolism • 2025-02-08	90.0	9	9	9	9
12	Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration. Nature communications • 2025-03-13	90.0	9	9	9	9
13	Gut Commensal Barnesiella Intestinihominis Ameliorates Hyperglycemia and Liver Metabolic Disorders. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-01-01	90.0	9	9	9	9
14	Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity. Cell research • 2025-01-29	90.0	9	9	9	9
15	Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling. Cell metabolism • 2025-04-18	88.5	9	8	9	9
16	Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring. Cell metabolism • 2025-01-16	88.5	9	9	9	8
17	Neutrophils preserve energy storage in sympathetically activated adipocytes. Nature • 2025-12-11	88.5	9	8	9	9
18	Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity. Nature communications • 2025-01-15	88.5	9	9	9	8
19	Thyrotropin Directly Affects Cardiac Electrophysiology and Is Associated With AF Prevalence. Circulation. Arrhythmia and electrophysiology • 2025-12-03	88.5	9	9	9	8
20	Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis. The Journal of clinical investigation • 2025-03-17	88.5	9	8	9	9
21	Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants. Atherosclerosis • 2025-12-02	88.5	9	8	9	9
22	Thalamic opioids from POMC satiety neurons switch on sugar appetite. Science (New York, N.Y.) • 2025-02-13	88.5	9	8	9	9
23	Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling. Science (New York, N.Y.) • 2025-04-03	88.5	9	9	9	8
24	Pharmacological targeting of BMAL1 modulates circadian and immune pathways. Nature chemical biology • 2025-03-26	88.5	9	8	9	9
25	A feeding-induced myokine modulates glucose homeostasis. Nature metabolism • 2025-01-03	88.5	9	8	9	9
26	APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus. Journal of virology • 2025-01-27	88.5	9	8	9	9
27	Identification of a molecular resistor that controls UCP1-independent Ca Cell metabolism • 2025-04-09	88.5	9	8	9	9
28	Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites. Cell genomics • 2025-03-22	88.5	9	8	9	9
29	NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis. Cell death and differentiation • 2025-03-24	88.5	9	8	9	9
30	SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2. Experimental & molecular medicine • 2025-01-01	88.5	9	9	9	8
31	PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis. Nature communications • 2025-12-11	88.5	9	9	9	8
32	Variable transduction of thyroid hormone signaling in structures of the mouse brain. Proceedings of the National Academy of Sciences of the United States of America • 2025-02-04	87.0	9	8	9	8
33	Single-cell immune transcriptomics reveals an inflammatory-inhibitory set-point spectrum in autoimmune diabetes. JCI insight • 2025-12-01	87.0	9	8	9	8
34	Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice. Nature communications • 2025-01-12	87.0	9	8	9	8
35	Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia: a data-driven analysis of randomised trials. The Lancet. Respiratory medicine • 2025-02-02	87.0	8	9	9	9
36	Brown adipose tissue alleviates podocyte apoptosis through NRG4 in a male mouse model of diabetic kidney disease. Diabetologia • 2025-02-27	87.0	9	8	9	8
37	A direct effect of the hematocrit on blood glucose: Evidence from hypoxia- and erythropoietin-treated mice. Science advances • 2025-04-16	87.0	9	8	9	8
38	A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes. The New England journal of medicine • 2025-03-19	87.0	8	9	9	9
39	Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice. Nature communications • 2025-01-25	87.0	9	8	9	8
40	LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity. Communications medicine • 2025-02-26	87.0	9	8	9	8
41	MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism. Science advances • 2025-03-12	87.0	9	8	9	8
42	USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice. Cell death and differentiation • 2025-01-20	87.0	9	8	9	8
43	BCL6 coordinates muscle mass homeostasis with nutritional states. Proceedings of the National Academy of Sciences of the United States of America • 2025-01-22	87.0	9	8	9	8
44	Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming. Cell metabolism • 2025-02-23	87.0	9	8	9	8
45	The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes. Nature metabolism • 2025-01-11	87.0	9	8	9	8
46	Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity. Nature cell biology • 2025-01-04	87.0	9	8	9	8
47	Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice. Journal of cachexia, sarcopenia and muscle • 2025-03-07	87.0	9	8	9	8
48	Meal-feeding promotes skeletal growth by ghrelin-dependent enhancement of growth hormone rhythmicity. The Journal of clinical investigation • 2025-04-01	87.0	9	8	9	8
49	Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis. Diabetes • 2025-03-10	87.0	9	8	9	8
50	Glutamatergic Input From Arcuate Nucleus Kiss1 Neurons to Preoptic Kiss1 Neurons Is Required for LH Surge in Female Mice. Endocrinology • 2025-01-27	87.0	9	8	9	8

About Scores

Innovation (0-10)

Degree of novel approaches or discoveries

Impact (0-10)

Potential impact on clinical practice

Rigor (0-10)

Robustness of research methodology

Citation (0-10)

Likelihood of being cited in future research