Human proteome distribution atlas for tissue-specific plasma proteome dynamics.

Summary

This study constructs a mass spectrometry-based atlas linking plasma proteins to their tissue of origin across 18 organs and major blood cell types, integrated with RNA/protein resources. The approach detects organ-enriched protein changes in six patient cohorts, including sepsis, providing a scalable framework for precision diagnostics and pathophysiology.

Key Findings

• Built a proteome atlas from 18 vascularized organs and 8 abundant blood cell types
• Integrated with RNA/protein atlases to define proteome-wide organ associations and infer tissue origin of plasma proteins
• Demonstrated disease-specific quantitative changes of organ-enriched protein panels in six patient cohorts, including sepsis
• Provides a reproducible, extensible strategy for plasma proteome dynamics in health and disease

Clinical Implications

Enables development of organ-specific plasma panels to differentiate sepsis endotypes and track organ injury (e.g., liver, kidney, endothelium), potentially informing targeted therapies and monitoring.

Limitations

• Abstract does not detail cohort sample sizes or clinical endpoints for sepsis
• Resource study; not a prospective diagnostic or interventional trial

Future Directions

Prospective validation of organ-specific panels for sepsis endotyping, integration with clinical decision tools, and testing utility for guiding organ-targeted therapies.