Sepsis - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper	Score
1	A consensus blood transcriptomic framework for sepsis. Nature medicine2025-10-01	93.0 Design 9 Novelty 10 Journal 10 Clinical 8
2	Human proteome distribution atlas for tissue-specific plasma proteome dynamics. Cell2025-04-10	91.5 Design 9 Novelty 9 Journal 9 Clinical 10
3	A consensus immune dysregulation framework for sepsis and critical illnesses. Nature medicine2025-10-01	91.5 Design 9 Novelty 9 Journal 10 Clinical 9
4	IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression. The Journal of clinical investigation2025-09-02	90.0 Design 9 Novelty 9 Journal 10 Clinical 8
5	Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis. Nature immunology2025-12-04	90.0 Design 9 Novelty 9 Journal 9 Clinical 9
6	Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis. The Journal of clinical investigation2025-03-03	90.0 Design 9 Novelty 9 Journal 9 Clinical 9
7	Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome. Microbiome2025-03-25	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
8	A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis. Science translational medicine2025-11-26	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
9	Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. The Lancet. Respiratory medicine2026-03-20	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
10	A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection. Cell reports. Medicine2026-01-04	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
11	Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli. Nature communications2025-03-13	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
12	Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition. Nature communications2025-03-21	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
13	Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury. Nature communications2026-02-15	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
14	A Multicomponent Intervention to Improve Maternal Infection Outcomes. The New England journal of medicine2025-11-19	88.5 Design 9 Novelty 8 Journal 10 Clinical 9
15	Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis. Critical care (London, England)2025-01-17	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
16	Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice. Nature microbiology2025-01-09	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
17	Microbiota-derived isovalerate ameliorates sex-specific gut barrier dysfunction in malnutrition. Proceedings of the National Academy of Sciences of the United States of America2026-08-11	88.5 Design 9 Novelty 9 Journal 10 Clinical 7
18	Activin A activation of Smad3 mitigates innate inflammation in mouse models of psoriasis and sepsis. The Journal of clinical investigation2025-03-12	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
19	Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation. Science (New York, N.Y.)2026-01-22	88.5 Design 9 Novelty 9 Journal 10 Clinical 7
20	Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis. The Journal of clinical investigation2025-09-02	88.5 Design 9 Novelty 9 Journal 10 Clinical 7
21	A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination. Immunity2025-02-28	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
22	Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion. European heart journal2025-12-04	88.5 Design 9 Novelty 9 Journal 9 Clinical 8
23	Macrophage memory emerges from coordinated transcription factor and chromatin dynamics. Cell systems2025-02-13	88.5 Design 9 Novelty 9 Journal 8 Clinical 9
24	Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation. Nature communications2025-10-11	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
25	Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. Science advances2025-02-14	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
26	Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice. Nature communications2026-03-28	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
27	Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation. eLife2025-03-17	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
28	De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses. Cell2025-05-29	87.0 Design 9 Novelty 9 Journal 10 Clinical 6
29	RPSA-OLFM4 axis governs neutrophil migration against bacterial infection and sepsis. Nature communications2026-04-26	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
30	A randomized, placebo-controlled trial of 13-valent pneumococcal conjugate vaccination to accelerate immune recovery after sepsis. Science translational medicine2026-08-12	87.0 Design 9 Novelty 8 Journal 10 Clinical 8
31	Disease tolerance and infection pathogenesis age-related tradeoffs in mice. Nature2026-01-15	87.0 Design 9 Novelty 9 Journal 10 Clinical 6
32	DLL4+ neutrophils promote Notch1-mediated endothelial PANoptosis to exacerbate acute lung injury in sepsis. The Journal of clinical investigation2025-12-15	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
33	Diagnostic performance and antibiotic impact of droplet digital PCR in suspected sepsis: the PROGRESS trial. Nature communications2026-09-17	87.0 Design 9 Novelty 8 Journal 9 Clinical 9
34	Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial. International journal of antimicrobial agents2025-04-12	87.0 Design 9 Novelty 8 Journal 9 Clinical 9
35	Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation. Cell metabolism2025-08-29	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
36	LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2. Autophagy2025-03-11	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
37	FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury. Nature communications2026-02-06	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
38	Transglutaminase 2 regulates vimentin-dependent proteostasis during macrophage activation. Science advances2026-08-28	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
39	DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis. Nature communications2026-03-10	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
40	Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset. Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025-05-25	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
41	Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut. Nature communications2026-03-25	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
42	Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. Cell2025-01-02	87.0 Design 9 Novelty 9 Journal 10 Clinical 6
43	Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation. Journal of immunology (Baltimore, Md. : 1950)2026-08-06	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
44	Prognostic Accuracy of the Phoenix Sepsis Criteria for Mortality in Children With Suspected Infection: A Systematic Review and Meta-Analysis. Critical care medicine2026-08-05	87.0 Design 9 Novelty 8 Journal 9 Clinical 9
45	AMBRA1 allosterically activates NLRP3 by releasing its autoinhibition. Nature immunology2026-09-10	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
46	Arginase 2 deficiency mitigates sepsis-associated acute kidney injury by alleviating lipid accumulation. Clinical and translational medicine2026-09-18	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
47	Soluble CD72 concurrently impairs T cell functions while enhances inflammatory response in sepsis. International immunopharmacology2025-01-11	87.0 Design 9 Novelty 9 Journal 8 Clinical 8
48	Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects. Proceedings of the National Academy of Sciences of the United States of America2026-02-11	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
49	Excessive HIF-1α driven by phospholipid metabolism causes septic cardiomyopathy through cytopathic hypoxia. Nature cardiovascular research2025-08-20	87.0 Design 9 Novelty 9 Journal 9 Clinical 7
50	Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. Nature communications2025-02-05	87.0 Design 9 Novelty 9 Journal 8 Clinical 8

About scores

Design1–10, weight 0.40: Robustness of the study methods
Novelty1–10, weight 0.30: Degree of novel approaches or findings
Journal1–10, weight 0.15: Standing of the journal
Clinical1–10, weight 0.15: Potential impact on clinical practice

The overall score is the weighted mean of the four axes on a 100-point scale. Journal standing is down-weighted in line with DORA.