Sepsis - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper Title	Total	Innovation	Impact	Rigor	Citation
1	Human proteome distribution atlas for tissue-specific plasma proteome dynamics. Cell • 2025-04-10	91.5	9	9	9	10
2	Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis. Nature immunology • 2025-12-04	90.0	9	9	9	9
3	Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis. The Journal of clinical investigation • 2025-03-03	90.0	9	9	9	9
4	Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome. Microbiome • 2025-03-25	88.5	9	8	9	9
5	Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli. Nature communications • 2025-03-13	88.5	9	8	9	9
6	Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition. Nature communications • 2025-03-21	88.5	9	8	9	9
7	Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis. Critical care (London, England) • 2025-01-17	88.5	9	9	9	8
8	Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice. Nature microbiology • 2025-01-09	88.5	9	8	9	9
9	Activin A activation of Smad3 mitigates innate inflammation in mouse models of psoriasis and sepsis. The Journal of clinical investigation • 2025-03-12	88.5	9	9	9	8
10	A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination. Immunity • 2025-02-28	88.5	9	8	9	9
11	Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion. European heart journal • 2025-12-04	88.5	9	9	9	8
12	Macrophage memory emerges from coordinated transcription factor and chromatin dynamics. Cell systems • 2025-02-13	88.5	9	8	9	9
13	Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. Science advances • 2025-02-14	87.0	9	8	9	8
14	Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation. eLife • 2025-03-17	87.0	9	8	9	8
15	Procalcitonin-guided early cessation of antibiotics prevents gut inflammation and preserves gut microbiome: Data from the PROGRESS controlled trial. International journal of antimicrobial agents • 2025-04-12	87.0	8	9	9	9
16	LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2. Autophagy • 2025-03-11	87.0	9	8	9	8
17	Soluble CD72 concurrently impairs T cell functions while enhances inflammatory response in sepsis. International immunopharmacology • 2025-01-11	87.0	9	8	9	8
18	Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. Nature communications • 2025-02-05	87.0	9	8	9	8
19	Uncovering a new family of conserved virulence factors that promote the production of host-damaging outer membrane vesicles in gram-negative bacteria. Journal of extracellular vesicles • 2025-01-22	87.0	9	8	9	8
20	Roles of TLR4 in macrophage immunity and macrophage-pulmonary vascular/lymphatic endothelial cell interactions in sepsis. Communications biology • 2025-03-22	87.0	9	8	9	8
21	CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis. EMBO reports • 2025-04-05	87.0	9	8	9	8
22	Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages. Science advances • 2025-01-22	87.0	9	8	9	8
23	Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells. Redox biology • 2025-03-30	87.0	9	8	9	8
24	Impaired megakaryopoiesis due to aberrant macrophage polarization via BTK/Rap1/NF-κB pathway in sepsis-induced thrombocytopenia. Molecular therapy : the journal of the American Society of Gene Therapy • 2025-01-01	87.0	9	8	9	8
25	Time-restricted feeding protects against septic liver injury by reshaping gut microbiota and metabolite 3-hydroxybutyrate. Gut microbes • 2025-04-14	87.0	9	8	9	8
26	Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence. Nature microbiology • 2025-04-12	87.0	9	8	9	8
27	Endothelial GSDMD underlies LPS-induced systemic vascular injury and lethality. JCI insight • 2025-02-10	87.0	9	8	9	8
28	Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11. Cell death discovery • 2025-12-11	87.0	9	8	9	8
29	ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury. Clinical and translational medicine • 2025-04-11	87.0	9	8	9	8
30	Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development. Critical care (London, England) • 2025-02-05	85.5	8	9	9	8
31	Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell-Dendritic Cell Interaction. Immunology • 2025-03-26	85.5	9	7	9	8
32	Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial. Nature medicine • 2025-04-03	85.5	8	9	9	8
33	Global emergence of Carbapenem-resistant Hypervirulent Klebsiella pneumoniae driven by an IncFII EBioMedicine • 2025-03-03	84.5	9	8	8	9
34	Clinical implement of Probe-Capture Metagenomics in sepsis patients: A multicentre and prospective study. Clinical and translational medicine • 2025-04-04	84.5	9	8	8	9
35	Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify pathways associated with mortality. The Journal of clinical investigation • 2025-12-02	84.0	8	8	9	8
36	GL-V9 inhibits Caspase-11 activation-induced pyroptosis by suppressing ALOX12-mediated lipid peroxidation to alleviate sepsis. British journal of pharmacology • 2025-04-16	84.0	9	8	9	6
37	Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. JAMA • 2025-12-08	84.0	8	8	9	8
38	Itaconate drives pro-inflammatory responses through proteasomal degradation of GLO1. Biochemical and biophysical research communications • 2025-01-10	83.0	9	8	8	8
39	The role of heme in sepsis induced Kupffer cell PANoptosis and senescence. Cell death & disease • 2025-04-13	83.0	9	8	8	8
40	H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis. MedComm • 2025-01-17	83.0	9	8	8	8
41	Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock. Journal of intensive care • 2025-02-21	83.0	9	8	8	8
42	Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study. The Lancet. Microbe • 2025-02-15	83.0	8	9	8	9
43	ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity. Cell reports • 2025-03-06	83.0	9	8	8	8
44	Inflammatory CD11c+ B Cells Induced by the TREM2 Signal Accelerate Sepsis Development. The Journal of infectious diseases • 2025-04-10	83.0	9	8	8	8
45	Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung. Nature communications • 2025-01-18	83.0	9	8	8	8
46	The Effect of Severe Sepsis and Septic Shock Management Bundle (SEP-1) Compliance and Implementation on Mortality Among Patients With Sepsis : A Systematic Review. Annals of internal medicine • 2025-02-17	83.0	8	9	8	9
47	Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots. Advanced materials (Deerfield Beach, Fla.) • 2025-01-08	83.0	9	8	8	8
48	Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice. Nature communications • 2025-12-04	83.0	9	8	8	8
49	Anserine reduces mortality in experimental sepsis by preventing methylglyoxal-induced capillary leakage. EBioMedicine • 2025-03-20	83.0	9	8	8	8
50	Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-03-28	82.5	8	7	9	8

About Scores

Innovation (0-10)

Degree of novel approaches or discoveries

Impact (0-10)

Potential impact on clinical practice

Rigor (0-10)

Robustness of research methodology

Citation (0-10)

Likelihood of being cited in future research