A modified screening protocol for ARDS in patients with respiratory support based on SpO
Summary
This single-center prospective study developed a modified ARDS screening protocol based on pulse oximetry (SpO2) in patients requiring respiratory support, using 161 patients for model derivation and 180 for validation. The approach aims to enable earlier, noninvasive ARDS identification when arterial blood gas sampling is impractical.
Key Findings
- Prospective observational enrollment of 341 patients requiring ABG and ECG monitoring.
- Model derivation in 161 patients and validation in 180 patients.
- A modified ARDS screening workflow grounded in SpO2 for patients on respiratory support was constructed and prospectively evaluated.
Clinical Implications
If validated across centers, SpO2-based screening could triage patients for confirmatory ABG, imaging, and early lung-protective strategies, integrating into ICU monitoring workflows.
Why It Matters
Noninvasive, rapidly obtainable SpO2-based screening could expand ARDS detection in resource-limited and real-time settings, potentially accelerating evidence-based interventions.
Limitations
- Single-center study with incomplete performance metrics in the abstract.
- External generalizability and threshold/algorithm specifics require full-text review and multicenter verification.
Future Directions
Multicenter external validation, EHR integration for automated alerts, and head-to-head comparisons with PaO2/FiO2-based screening.
Study Information
- Study Type
- Cohort
- Research Domain
- Diagnosis
- Evidence Level
- III - Prospective observational model development/validation without randomization.
- Study Design
- OTHER