Daily Cosmetic Research Analysis
A ROS-responsive collagen hemostatic sponge with on-demand vancomycin release accelerated healing in MRSA-infected wounds in preclinical models. A PRISMA-guided murine systematic analysis indicates smoother breast implant surfaces elicit thinner capsules and less inflammation versus textured and polyurethane coatings. Environmental fungi biotransformed sunscreen UV filters, modulating endocrine activities while reducing toxicity, suggesting feasible bioremediation paths.
Summary
A ROS-responsive collagen hemostatic sponge with on-demand vancomycin release accelerated healing in MRSA-infected wounds in preclinical models. A PRISMA-guided murine systematic analysis indicates smoother breast implant surfaces elicit thinner capsules and less inflammation versus textured and polyurethane coatings. Environmental fungi biotransformed sunscreen UV filters, modulating endocrine activities while reducing toxicity, suggesting feasible bioremediation paths.
Research Themes
- Smart biomaterials for infected wound care
- Host–implant interface and surface texture biology
- Bioremediation of cosmetic ingredients and endocrine activity
Selected Articles
1. Development of ROS-responsive collagen-based hemostatic sponges for the repair of MRSA-infected wounds.
A collagen sponge engineered for ROS-triggered, covalently tethered vancomycin release improved hemostasis and accelerated healing in MRSA-infected full-thickness wound models. Amino-rich modification boosted drug loading and mechanical/biologic performance, outperforming non-ROS and adsorption controls.
Impact: Introduces a smart, infection-responsive hemostatic biomaterial that couples rapid hemostasis with targeted antimicrobial delivery—addressing two major barriers to healing in contaminated wounds.
Clinical Implications: If translated, ROS-triggered on-demand antibiotic delivery could reduce systemic antibiotic exposure, enhance control of MRSA in contaminated wounds, and improve outcomes in complex surgical and reconstructive settings.
Key Findings
- Amino-rich chemical modification of collagen increased primary amine content, improving vancomycin loading, mechanical strength, and hemostatic performance.
- ROS-responsive covalent linkage enabled controlled vancomycin release with superior anti-MRSA efficacy versus non-ROS and physical adsorption approaches.
- In MRSA-infected full-thickness wound models, the ROS-responsive sponge significantly accelerated healing and skin regeneration compared with controls.
Methodological Strengths
- Direct comparison with non-ROS-responsive and physical adsorption controls in infected full-thickness wound models
- Integrated materials characterization linking chemistry to hemostatic function and antibacterial performance
Limitations
- Preclinical animal data only; human safety and efficacy are untested
- Sample size and detailed statistical parameters are not specified in the abstract; long-term resistance and biocompatibility require study
Future Directions: Conduct GLP toxicology and large-animal studies, evaluate spectrum against polymicrobial biofilms, optimize antibiotic payloads, and design first-in-human trials in contaminated surgical wounds.
2. Inflammatory response to various implant surfaces in murine models: A systematic analysis.
Across murine models, smooth breast implant surfaces produced thinner, more organized capsules with lower inflammation, whereas increasing texture—particularly polyurethane foam—drove denser capsules and robust inflammatory responses. Findings emphasize surface texture as a key determinant of host response.
Impact: Synthesizes preclinical evidence under standardized ISO categories, informing implant surface selection and future design to mitigate capsular contracture and inflammation.
Clinical Implications: Preferencing smoother surfaces may reduce inflammatory capsule formation; however, translation to human outcomes requires cautious extrapolation and clinical validation.
Key Findings
- Smooth implant surfaces were associated with thinner, more orderly capsules and lower inflammation in murine models.
- Micro- and macrotextured surfaces induced progressively greater tissue integration and inflammatory responses.
- Polyurethane-coated implants elicited robust inflammation with increased neoangiogenesis and thicker, more cellular capsules.
Methodological Strengths
- PRISMA-guided systematic review across multiple databases with ISO 14607:2018-based surface classification
- Comparative assessment of capsule histology, inflammation patterns, and biomechanics
Limitations
- Preclinical murine data with heterogeneity and data inconsistencies limit direct clinical translation
- Exclusion of human studies precludes direct estimation of patient-relevant outcomes
Future Directions: Harmonize animal model protocols aligned with ISO surface metrics and bridge to human registries and trials assessing capsular contracture and inflammation endpoints.
3. Biotransformation of oxybenzone and 3-(4-methylbenzylidene)camphor in Cunninghamella species: Potential for environmental clean-up of widely used sunscreen agents.
Cunninghamella species degraded oxybenzone and 4-MBC, with C. blakesleeana showing the highest removal efficiency, while processed products lacked mutagenicity and HepG2 cytotoxicity but displayed altered endocrine activities. CYP450 participation was implicated, indicating fungal detoxification pathways relevant to OUVF bioremediation.
Impact: Demonstrates, for the first time, fungal biotransformation of widely used sunscreen agents with multi-assay toxicology profiling, opening a plausible route for environmental clean-up of cosmetic UV filters.
Clinical Implications: While primarily environmental, insights could inform safer sunscreen formulations and wastewater management, potentially reducing human and ecological exposure to persistent OUVFs.
Key Findings
- Cunninghamella strains utilized OUVFs; C. blakesleeana achieved the most efficient removal of oxybenzone and 4-MBC, comparable to A. niger.
- Fungus-processed samples were non-mutagenic (Ames test) and non-cytotoxic to HepG2 cells, with improved SH-SY5Y neurotoxicity and ecotoxicity profiles.
- Endocrine activities shifted post-biotransformation: BP-3 showed higher estrogenic agonism and reduced androgen antagonism; 4-MBC lost estrogenic agonism but gained estrogenic antagonism.
- CYP450 enzymes were implicated in biotransformation, elucidating fungal detoxification pathways.
Methodological Strengths
- Use of multiple fungal strains with parallel toxicology assessment (Ames, HepG2, SH-SY5Y, ecotoxicity) and in silico analysis
- Mechanistic probing via CYP450 inhibition to map biotransformation pathways
Limitations
- Laboratory conditions may not reflect environmental complexity; fate and safety of all metabolites remain to be fully characterized
- Endocrine activity shifts warrant cautious interpretation regarding ecological and human health impacts
Future Directions: Scale-up bioreactors with mixed microbial consortia, comprehensive metabolite identification, and real-world wastewater validation to inform regulatory and formulation strategies.