Daily Cosmetic Research Analysis
Today's top studies span clinical dermatologic surgery, consensus-based safety standards for aesthetic injectables, and an age-tailored artificial skin model for cosmetic formulation testing. Together, they advance oncologic-cosmetic decision-making, standardize ultrasound use to reduce filler-related complications, and provide a reproducible in vitro platform to optimize age-specific cosmetic film performance.
Summary
Today's top studies span clinical dermatologic surgery, consensus-based safety standards for aesthetic injectables, and an age-tailored artificial skin model for cosmetic formulation testing. Together, they advance oncologic-cosmetic decision-making, standardize ultrasound use to reduce filler-related complications, and provide a reproducible in vitro platform to optimize age-specific cosmetic film performance.
Research Themes
- Safety and standardization in aesthetic injectables via ultrasound
- Age-specific artificial skin models for cosmetic film optimization
- Oncologic-cosmetic balance in basal cell carcinoma surgery
Selected Articles
1. Age-tailored artificial skin model for cosmetic film development.
Using micro-CT-derived topographies from young and aged Korean skin, the authors built PDMS replicas to quantify how age-related roughness and wrinkles alter cosmetic thin-film deposition. The model, further refined by incorporating porosity and sebum, enables standardized age-specific evaluation of film coverage to guide formulation optimization.
Impact: Introduces a reproducible, age-tailored in vitro platform to quantify cosmetic film behavior, reducing reliance on human testing and enabling targeted formulation for different age groups.
Clinical Implications: While not a clinical study, this model can inform dermatologists and cosmetic scientists by predicting coverage challenges in aged skin and accelerating development of products tailored to age-related topography.
Key Findings
- Micro-CT revealed age-dependent topographies that influence thin-film deposition.
- PDMS-based replicas enabled quantitative film coverage assessment on human-derived positives and the model.
- An improved model incorporating skin porosity and sebum was proposed to enhance realism.
Methodological Strengths
- High-resolution X-ray microtomography to capture true skin topography.
- Direct comparison between human-derived skin positives and PDMS models with quantitative metrics.
Limitations
- Validation appears limited to a Korean cohort; generalizability across ethnicities and sites is uncertain.
- Lacks correlation with user-perceived outcomes and dynamic biomechanical skin behavior.
Future Directions: Validate across diverse populations and facial/body sites, correlate model outputs with clinical/user outcomes, and incorporate sweat/sebum dynamics and elasticity for real-world prediction.
2. The use of ultrasound imaging in aesthetic injectables: A modified Delphi consensus.
An international panel achieved consensus on prerequisites and best practices for ultrasound in aesthetic injections: at least a 15 MHz linear probe, mandatory B-mode/Color and Spectral Doppler with archiving, and recommended Power Doppler. Ultrasound scanning is mandatory in high-risk vascular areas and for complication management, and ultrasound-guided injections are recommended across many facial regions with strict sterile technique.
Impact: Provides the first international, multi-specialty consensus detailing equipment, indications, and training for ultrasound use in aesthetic injectables, enabling safer, standardized practice and likely reducing severe vascular events.
Clinical Implications: Adopt routine pre-injection ultrasound scanning in high-risk zones, document with archiving, identify prior fillers, and use ultrasound guidance (with sterile probe cover/gel) for fillers, toxin, and injection lipolysis; implement a structured training curriculum before clinical use.
Key Findings
- Minimum equipment: ≥15 MHz linear probe; B-mode, Color and Spectral Doppler, and archiving are mandatory; Power Doppler recommended; handheld devices are acceptable.
- Ultrasound prior to injection is mandatory in high-risk vascular areas and for complication management; identify prior fillers before injecting.
- Ultrasound-guided injections are recommended in many facial regions for fillers, toxin, and injection lipolysis; sterile probe cover and gel are required; necessary for precise intralesional injections in complication treatment.
Methodological Strengths
- Structured four-round modified Delphi with international, multi-specialty experts.
- High agreement thresholds (>70%) achieved for most statements, yielding actionable guidance.
Limitations
- Expert consensus without prospective outcome validation; potential panel selection bias.
- No patient-level data to quantify complication rate reduction after implementation.
Future Directions: Prospective, multicenter studies to quantify complication reduction with ultrasound-guided practice and development of competency-based training and certification frameworks.
3. Exploring the role of surgical margins and reoperation in basal cell carcinoma recurrence: a study of 3036 cases.
In a retrospective analysis of 3036 excisions (2037 patients), complete excision was achieved in 93.3%, but incomplete margins were more frequent in head/neck sites and certain histologic subtypes. Reoperation for high-risk BCCs significantly lowered recurrence (0.52%), and narrow margins correlated with higher recurrence, underscoring the need for adequate clearance.
Impact: Large-scale real-world data clarify when to prioritize reoperation and how margin width impacts recurrence, informing surgical planning that balances oncologic control with cosmetic outcomes.
Clinical Implications: For high-risk or head/neck BCCs with incomplete excision, prioritize reoperation and avoid overly narrow margins to minimize recurrence; integrate risk stratification into preoperative counseling regarding cosmetic trade-offs.
Key Findings
- Complete excision rate was 93.3%; incomplete excisions were more common in head/neck sites and certain histologic subtypes.
- Reoperation for high-risk BCCs significantly reduced recurrence, with an overall recurrence of 0.52%.
- Narrow excision margins were associated with higher recurrence.
- Nodular subtype was most common (45.85%); head was the most affected site (54.74%).
Methodological Strengths
- Large sample size across 3036 excisions with standardized surgical protocols.
- Stratified analysis by anatomical site and histologic subtype.
Limitations
- Retrospective, single-region study; potential residual confounding.
- Margin widths and follow-up duration not detailed in the abstract.
Future Directions: Prospective studies to define optimal margins by risk strata, assess cosmetic/functional outcomes, and evaluate cost-effectiveness of reoperation versus surveillance.