Daily Cosmetic Research Analysis

Ultraviolet filters (UVFs) are widely used in personal care products, their occurrence in the environment and potential detrimental effects on human health have raised significant concerns. This case-control study included 102 women-34 with diminished ovarian reserve (DOR) and 68 healthy controls-and aimed to investigate the association between UVF exposure and DOR. We collected and analyzed follicular fluid (FF) samples from women diagnosed with DOR and compared them to samples from a control group, measuring the concentrations of 16 different UVFs. Four individual compounds showed significantly higher concentrations in the DOR group: octyl methoxycinnamate (OMC), UV-P, UV-328, and Ensulizole. The cumulative concentration of ten UVFs with detection frequencies above 50 % was also markedly elevated in the DOR group (median ΣUVFs: 178.96 ng/mL vs. 23.93 ng/mL, p < 0.001). OMC exhibited the highest median concentration (170.81 ng/mL in DOR vs. 20.77 ng/mL in controls, p < 0.001), followed by UV-P, UV-328, and Ensulizole. Spearman analysis revealed significant negative correlations between OMC concentrations with ovarian reserve biomarkers such as anti-Müllerian hormone (AMH), antral follicle count (AFC), and the number of oocytes retrieved during ovarian stimulation cycles, while exhibiting a positive correlation with follicle-stimulating hormone (FSH) levels. Adjusted logistic regression models demonstrated that elevated OMC levels were associated with a 3.8-fold increased risk of DOR (95 % CI: 1.943-9.782, p < 0.001). These results highlight the urgent need for further investigation into the mechanisms by which UVFs affect ovarian reserve, as well as their potential long-term implications for fertility.

BACKGROUND: The median sternotomy incision is a common approach in cardiac surgery, often leading to noticeable scar formation that can impact patients' quality of life. This study aims to compare outcomes between subcuticular suture and adhesive strip (Steri-stripTM, 3M HealthCare®) closure techniques for median sternotomy incisions in cardiac surgery patients. METHODS: In this prospective randomized controlled trial, 112 patients undergoing cardiac surgery (August 2020 to September 2021) were assigned to either the adhesive strip or subcuticular suture group. Wound assessments occurred on postoperative days 3, 7, and before discharge, monitoring for infection and dehiscence. Follow-ups at 1-2 weeks, 3 months, and 6 months used scar scales, including Vancouver Scar Scale (VSS), Manchester Scar Scale (MSS), and Patient and Observer Scar Assessment Scale (POSAS). RESULTS: Out of a total of 112 patients, 6 were excluded. All remaining patients were completely followed up. No significant differences were observed in VSS, MSS, POSAS outcomes, or wound complications during postoperative follow-ups. Adhesive strip closure took 0.49 minutes, significantly less than 7.27 minutes for subcuticular sutures (P < 0.001). Furthermore, the total cost of adhesive strips was lower than the subcuticular suture group. CONCLUSION: The adhesive strips application for skin closure of median sternotomy wounds was found to be non-inferior to subcuticular sutures in terms of clinical outcomes and postoperative wound complications. Additionally, this approach resulted in reduced operative time and proved to be cost-effective in hospital care. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

BACKGROUND: Labiaplasty often motivated by aesthetic and/or sexual and/or functional concerns, but with contradictory outcomes. The documentation regarding the safety and efficacy of these elective procedures is limited, primarily consisting of clinical case reports and retrospective studies. OBJECTIVES: This systematic review aimed to investigate the effect of labiaplasty on sexual function. METHODS: An electronic search in PubMed, Web of Science, Scopus, PsycINFO, Embase, the Cochrane Library, and ClinicalTrials.gov from 2000 to 2024 was performed. Articles that focused on labia minora surgeries performed for cosmetic, and/or sexual, and/or psychological, and/or functional reasons (excluding medical indications like reversing female genital cutting, straddle injuries, or other genital injuries) were considered. Additionally, selected articles were required to evaluate post-operative sexual function using a quantitative tool. A meta-analysis using a random-effects model was used to derive weighted pooled estimates of sexual function after labiaplasty. RESULTS: The authors identified a total of 11 articles (with 671 participants) that evaluated sexual function after labiaplasty. Based on the Effective Public Health Practice Project's Quality Assessment Tool for Quantitative Studies (EPHPP), out of the 11 articles reviewed, 7 were categorized as weak, 4 as moderate, and none as strong. Of the studies reviewed, 6 studies used Female Sexual Function Index (FSFI). A meta-analysis of these six studies (with eight groups) revealed that labiaplasty was associated with an 18.8% improvement in the FSFI score, P < 0.001. CONCLUSION: Labiaplasty appears to have a positive impact on women's sexual function, at least in the short term. However, inconsistencies in procedures, study design, and scales have limited this conclusion. In pre-surgery counseling, patients must be informed about the limited knowledge on labiaplasty's impact on sexual function. LEVEL OF EVIDENCE III: Evidence obtained from well-designed analytic studies. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .