Daily Cosmetic Research Analysis
Today’s top cosmetic-related research spans two meta-analyses and one clinical cohort. Aesthetic biostimulants show high patient satisfaction with mostly minor adverse events, and single-site laparoscopic hysterectomy yields fewer complications and shorter operative time than multi-port approaches. In rhinoplasty, fresh frozen homologous costal cartilage appears safe with meaningful functional and cosmetic PROM improvements.
Summary
Today’s top cosmetic-related research spans two meta-analyses and one clinical cohort. Aesthetic biostimulants show high patient satisfaction with mostly minor adverse events, and single-site laparoscopic hysterectomy yields fewer complications and shorter operative time than multi-port approaches. In rhinoplasty, fresh frozen homologous costal cartilage appears safe with meaningful functional and cosmetic PROM improvements.
Research Themes
- Injectable biostimulants for aesthetic rejuvenation
- Minimally invasive single-site surgery and cosmetic/functional trade-offs
- Allogeneic cartilage grafting in rhinoplasty
Selected Articles
1. Biostimulants in Aesthetic Medicine: A Systematic Review and Meta-analysis of Efficacy, Safety, and Patient Satisfaction.
Across 25 observational studies, biostimulants achieved a pooled 91% satisfaction rate, with mostly minor adverse events; pain was common (92%), and nodules were infrequent (~5%). Despite high heterogeneity, dermal, volumetric, and anatomic outcomes generally improved.
Impact: This synthesis provides the most comprehensive quantitative safety and satisfaction profile to date across major biostimulants, informing patient counseling and product selection.
Clinical Implications: Clinicians can counsel patients that satisfaction is high and adverse events are typically mild (notably transient pain). Standardized outcome measures and head-to-head trials are needed to refine agent selection and dosing.
Key Findings
- Pooled satisfaction rate with biostimulants was 91% (95% CI 67–98%; I2=87.3%).
- Common adverse events: pain 92% (I2=87.7%), bruising 27% (I2=96%), ecchymosis 22% (I2=95.5%), erythema 16% (I2=94.3%), edema 5% (I2=93.6%), nodules 5% (I2=85.5%).
- Non-meta-analyzed studies consistently reported improvements in dermal, volume, anatomic, and satisfaction endpoints.
Methodological Strengths
- Comprehensive multi-database search up to January 14, 2025
- Random-effects meta-analyses across multiple clinically relevant outcomes
Limitations
- High heterogeneity (I2 often >85%) across outcomes
- Evidence base limited to observational studies; risk of bias and confounding
Future Directions: Conduct head-to-head randomized trials comparing CaHA, PLLA, and PCL; standardize outcome measures; assess long-term nodule rates and mitigation strategies.
2. Comparison of single-site to multi-port laparoscopic hysterectomy in patients with benign or malignant gynecological diseases: A meta-analysis of 3309 patients.
Across 3309 patients, single-site laparoscopic hysterectomy had fewer complications (RR 0.46) and shorter operative time (~13.7 minutes less) than multi-port, with no differences in blood loss, stay, or postoperative pain/infections.
Impact: Provides pooled comparative safety/efficacy for single-site versus multi-port hysterectomy, informing surgical choice where cosmesis and minimally invasive approaches are valued.
Clinical Implications: SS-LH can be considered when prioritizing reduced complications and operative time without compromising other perioperative outcomes; training and patient selection remain key.
Key Findings
- SS-LH reduced overall complications versus MP-LH (RR=0.46; p=0.0005).
- SS-LH had shorter operative time (MD=13.70 minutes; p=0.02).
- No significant differences in blood loss, length of stay, conversion rate, postoperative pain, fever, port-site infection, or port hernia.
Methodological Strengths
- PRISMA準拠の文献検索と選別（PubMed、CENTRAL、Embase）
- 複数アウトカムのメタ解析により一貫した効果推定を提供
Limitations
- Mixed inclusion of RCTs and cohort studies; residual confounding possible
- Heterogeneity in surgeon expertise and perioperative protocols across studies
Future Directions: Undertake multicenter RCTs with standardized endpoints, long-term follow-up for port-site hernia and cosmesis, and subgroup analyses by uterus size and pathology.
3. Surgical and Patient Reported Outcomes of Fresh Frozen Homologous Costal Cartilage in Primary, Revision, and Functional Rhinoplasty.
In a single-surgeon retrospective cohort of 123 rhinoplasties using FFHCC, complications were low (infection 2.4%, resorption 0.8%) and multiple PROMs (NOSE, SNOT-22, ESS, SCHNOS) improved significantly at a mean 11-month follow-up.
Impact: Offers real-world safety and patient-centered outcomes supporting FFHCC as an off-the-shelf alternative to autologous cartilage for both cosmetic and functional rhinoplasty.
Clinical Implications: FFHCC may reduce donor-site morbidity and expand graft availability while maintaining functional and cosmetic improvement; patient selection and graft handling remain important.
Key Findings
- Low complication rates: infection 2.4% (3/123) and resorption 0.8% (1/123).
- Significant PROM improvements: NOSE (-7.9), SNOT-22 (-18.9), ESS (-4.8), SCHNOS total (-13.5), functional (-5.1), cosmetic (-8.2); all p<0.001.
- Mean follow-up was 11 months (range 1–44 months).
Methodological Strengths
- Multiple validated PROMs capturing functional and cosmetic domains
- Clear reporting of complication rates with defined follow-up
Limitations
- Single-surgeon, retrospective design limits generalizability and introduces selection bias
- No control group (e.g., autologous cartilage) for comparative effectiveness
Future Directions: Prospective, multicenter comparative studies versus autologous costal cartilage with longer follow-up to assess resorption/warping, infection, and cost-effectiveness.