Daily Cosmetic Research Analysis

As concealment methods for illegal cosmetic adulteration advance, identifying non-library or unexpected additives remains challenging. This study presents a novel integrated strategy for rapid, non-targeted detection of reference-standard-free illegal cosmetic additives, especially emerging structural analogs of known prohibited compounds. The quinolone case study validated the strategy's broad applicability to cosmetics. Mass spectrometry-based feature-based molecular networking (FBMN) leverages spectral similarity to cluster structural analogs, using known compounds to identify unknowns, thereby significantly expediting unknown compound discovery. Our results suggested that FBMN clustered 51 quinolones (including 14 novel synthetic analogs) into 13 structural groups using only 17 "seed" standards, achieving high sensitivity with a limit of detection (LOD) of 1 ppm. The quantitative structure-ionization intensity relationship (QSIIR) model was established using multiple linear regression (MLR). It employed 7 structural descriptors to predict concentrations of quinolones with high accuracy (training R

BACKGROUND: The facial artery (FA), as the primary vascular structure of the face, exhibits numerous anatomical variations. Determining its anatomical variation (vascular mapping) by ultrasonography (US)-a non-invasive, low-cost, practical, and bedside-applicable imaging technique-helps achieve safe aesthetic injections, averting complications such as ischemia and necrosis. OBJECTIVES: This study aimed to evaluate the anatomical characteristics of FA under the guidance of US, including course variations in relation to the nasolabial fold (NLF), depth, and diameter. METHODS: This systematic review and meta-analysis used the 2020 update of the PRISMA guidelines. The detailed protocol is registered with PROSPERO. Original studies with extractable numerical data that applied Doppler US in normal adult populations to illustrate FA anatomy were evaluated. The primary two outcomes of the study were (1) the pooled visualization rate of the FA in each of the three anatomical levels and (2) the pooled prevalence of each FA course variation according to the NLF. RESULTS: A systematic search through the three online databases identified 1087 records, of which 580 underwent title and abstract screening after duplicate removal, and 10 studies were included. The visualization rates at three anatomical facial levels were 100%, 99.9%, and 99.8% of all arteries. FA running medial to the NLF (type A) (46.2%), followed by FA crossing medial to lateral of the NLF (type C) (22.5%), were the most frequent courses of FA in relation to the NLF. In contrast, the FA running lateral to the NLF (type B) (12.0%) was the scarcest variation. The FA became more profound in the skin layers as it ascended in the face from level 1 (6.27 mm) to level 3 (8.04 mm). Moreover, the FA narrowed in diameter from level 1 (2.14 mm) to level 3 (1.46 mm) as it branched out and approached its termination point. Therefore, the total prevalence of angular, lateral nasal, and superior labial artery as the final branch of the FA in our study was 71.8%, 27.9%, and 5.7%, respectively. CONCLUSIONS: According to the results, the US could detect FA in almost all cases at the three levels of the face, including the lower border of the mandible, cheilion, and lateral nasal ala. This systematic review and meta-analysis provided a comprehensive anatomical knowledge of the Doppler-visualized FAs as an exemplary schema of pre-procedural vascular mapping that can help aestheticians prevent intravascular injections, exerting safer performance during cosmetic procedures. TRIAL REGISTRATION: PROSPERO number: CRD42024616195.

INTRODUCTION AND AIMS: Titanium dental implants are widely used in clinical practice; however, they still face challenges such as implant loosening and infection. Recent studies focus on improving integration and infection resistance. In this study, a low-temperature plasma treatment was employed to fabricate a dual-functional modification layer on the titanium implant surface, offering a promising strategy that simultaneously promoted bone integration and effectively inhibited bacterial infection. MATERIALS AND METHODS: This was achieved by depositing a hexamethyldisilazane (HMDSZ) film on the surface of titanium implants and grafting a thermosensitive composite hydrogel designed as a drug delivery system. The natural cross-linker genipin was used to immobilize chlorhexidine on the implant collar (2 mm in length). Meanwhile, bone morphogenetic protein-2 was immobilized on the implant body (6 mm in length), ensuring controlled release to promote bone regeneration and provide strong antibacterial effects. Various experimental analyses were conducted to characterize the samples, including assessments of hydrophilicity, functional groups, elemental composition, and surface morphology. Validation was carried out through in vitro tests (cytotoxicity, mineralization, and antibacterial assays) and in vivo animal experiments (bone-to-implant contact and Periotest measurements). RESULTS: Biocompatibility tests indicated that the plasma-treated surfaces did not exhibit cytotoxicity and facilitated osteoblast differentiation and osseointegration. The hydrogel effectively served as a carrier for the controlled release of growth factors and antibacterial agents, thereby boosting the osseointegration and antibacterial properties of the titanium implants. In vivo studies in swine models demonstrated superior bone integration and antibacterial efficacy compared to untreated and commercial implants within 2 weeks. CONCLUSION: The surface modification method proposed in this study successfully produced titanium implants with dual-functional surfaces, enhancing both osseointegration efficiency and antibacterial capability. CLINICAL SIGNIFICANCE: This approach enables implants to perform specific functions through the use of growth factors and antimicrobials, potentially advancing implant technology and improving clinical outcomes.