Daily Cosmetic Research Analysis

BACKGROUND: Rhinoplasty enhances nasal aesthetics and function but faces challenges in thick-skinned patients due to limited contour definition and higher risks of scarring and complications. Isotretinoin shows promise in reducing skin thickness and improving healing, but its side effects necessitate careful monitoring. AIM: To consolidate existing evidence on isotretinoin efficacy, safety, and impact on satisfaction to guide decision-making for this patient population. METHODS: We retrieved relevant articles up to December 2024 from PubMed, Scopus, Web of Science, and Cochrane Library. Data were extracted from eligible studies by two independent reviewers, including baseline information, type of surgery, isotretinoin regimen, study outcomes, and complications. RESULTS: Higher satisfaction was found with isotretinoin use post-rhinoplasty at three and six months post-op; however, satisfaction often declined by 12 months. Isotretinoin improved cosmetic results, reducing skin thickness and enhancing nasal definition for up to six months. Nonetheless, differences in outcomes between intervention and control groups diminished by one year. Complications like dryness were common but manageable, while systemic side effects were rare. CONCLUSION: Isotretinoin offers short-term benefits after rhinoplasty for thick-skinned patients, with diminishing effects by one year. Similar efficacy was noted for both oral and topical formulations, favoring topical formulations for their milder side effects. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

PURPOSE: The P4HB scaffold (GalaFLEX) is an effective tool in breast reconstruction, but its role in cosmetic breast procedures, such as mastopexy, requires further evaluation. We performed a proportions meta-analysis to assess the efficacy and safety of P4HB scaffold use in aesthetic breast surgery. METHODS: A systematic literature search was conducted in PubMed, Cochrane Library, and Embase through December 2024 for studies on cosmetic breast surgery using the P4HB scaffold that reported safety and efficacy outcomes. A random-effects model and Freeman-Tukey double arcsine transformation were applied. Statistical analyses were performed using R version 4.1.2. RESULTS: Three studies with 406 female patients (average age 39) were included, with mastopexy and augmentation-mastopexy being the most common procedures. Pooled analysis showed a delayed wound healing rate of 5.94 per 100 (95% CI: 0.34-16.62%), recurrent implant malposition at 0.47 per 100 (95% CI: 0.00-1.58%), infection at 0.42 per 100 (95% CI: 0.00-2.47%), seroma at 0.31 per 100 (95% CI: 0.00-1.32%), recurrent capsular contracture at 0.18 per 100 (95% CI: 0.00-1.21%), scaffold palpability at 0.11 per 100 (95% CI: 0.00-0.93%), and red breast syndrome at 0.00 per 100 (95% CI: 0.00-1.22%). CONCLUSION: This meta-analysis suggests that the P4HB scaffold may be a valuable adjunct in aesthetic breast procedures, potentially reducing complications such as implant malposition and capsular contracture, while showing low rates of other complications including delayed wound healing, infection, and seroma. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

INTRODUCTION: Combined aesthetic surgeries, where multiple cosmetic procedures are performed in a single operative session, have gained popularity due to benefits like shorter overall recovery time and reduced costs. However, the safety and outcomes associated with combining procedures remain variably reported. This study evaluates the risk factors, complication rates, and outcomes of combined versus individual aesthetic surgeries. METHODS: This retrospective analysis was conducted using patient records from two medical centers in Riyadh, Saudi Arabia, where aesthetic surgeries were performed by a senior surgeon. Patients were included if they underwent either a single aesthetic procedure or a combined set of procedures frequently paired with abdominoplasty, such as liposuction, breast augmentation, or mastopexy. Key outcomes assessed included complication rates (e.g., infections, seromas, hematomas), the incidence of reoperations, and hospital readmissions within 30 days postoperatively, which were collected to evaluate the overall safety and risk profile of combined versus individual aesthetic procedures. RESULTS: A total of 670 patients were analyzed, with a median age of 37 years and a majority being female (89.1%). Among the patients, 28.1% underwent combined procedures, most commonly abdominoplasty with liposuction (15.4%) and abdominoplasty with breast surgery (6.1%). The overall complication rate was 7.9%, with infections being the most frequent (28.3%). Combined procedures showed significantly higher complication rates compared to single procedures (49.1% vs. 26.3%, p < 0.001). Specifically, abdominoplasty combined with breast surgery and abdominoplasty combined with liposuction were associated with higher complication rates (p = 0.011 and p = 0.002, respectively). CONCLUSION: Combined aesthetic procedures carry a higher complication risk compared to individual surgeries, particularly when abdominoplasty is paired with liposuction or breast surgery. These findings highlight the need for careful patient selection, risk assessment, and thorough preoperative counseling to improve safety and patient satisfaction in combined aesthetic surgeries. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.