Daily Cosmetic Research Analysis

OBJECTIVES: With the growing popularity of rhinoplasty, techniques for enhancing functional and aesthetic outcomes are evolving. This study aims to compare 2 methods in rhinoplasty-sutured scroll reconstruction versus no scroll repair-focusing on their effects on nasal breathing, aesthetic results, and patient satisfaction. METHODS: This randomized controlled study at Taleghani Hospital in Tehran involved female patients aged 18 to 50 years undergoing primary rhinoplasties. Participants were assigned to 2 groups, and only 1 received sutured horizontal scroll ligament repair. Outcomes were assessed using the FACE-Q rhinoplasty module for patient satisfaction and rhinomanometry for nasal function, with independent surgeons evaluating aesthetic results via a Visual Analog Scale. For statistical analyses SPSS version 22.0 was used, with significance set at RESULTS: The study involved 164 female patients, with 82 in the sutured scroll ligament group and 82 in the no scroll repair group. The mean age was 26.32 ± 6.86 years (range = 19-46). No significant baseline differences were found. After a mean follow-up of 11.6 months, no patients required revision surgery. Post-operative FACE-Q scores and VAS ratings were higher in the sutured group. The mean postoperative peak inspiratory nasal flow (PNIF) was 116.42 ± 13.78 ml/minute in the sutured group versus 111.08 ± 15.67 ml/minute in the other group ( CONCLUSION: This randomized clinical trial emphasizes on the positive effect of ensuring the scroll ligament repair using sutures on the facial aesthetics, quality of life, and functional capacity of patient after the surgery. Which is consistent with the prior studies indicating both cosmetic and functional benefits for scroll preservation/reconstruction.

This work presents a novel, non-invasive method that combines high-resolution 3D Line-field Confocal Optical Coherence Tomography (LC-OCT) images with an advanced, in-house developed automated 3D segmentation algorithm to quantitatively analyze dermal fiber characteristics in vivo. This approach marks the first in-depth investigation of dermal fibers, enabling precise characterization of age-related changes, ethnic differences, and the effects of anti-aging skincare products on the cheekbone region of Caucasian and Asian women. Our algorithm accurately extracts fiber metrics, revealing that aging correlates with shorter fiber length and increased anisotropy. Although Asians exhibited a denser fiber network than Caucasians, both ethnicities showed comparable mean fiber lengths and anisotropy. Furthermore, anti-aging skincare treatments significantly enhanced fiber length, node count, and network density while reducing anisotropy over one and three months. This innovative integration of cutting-edge imaging and algorithmic analysis provides valuable insights for cosmetic applications and paves the way for future non-invasive dermatological research.

INTRODUCTION: Treating older patients with cutaneous neoplasms (CN) can be challenging as oncological resection and definitive external beam radiotherapy (EBRT) can both have limitations in terms of their therapeutic ratio at critical anatomical sites. Here, we present the cohort study results of high-dose-rate (HDR) mould-based brachytherapy (MbBT) for CN focusing on oncological outcomes and patient-reported outcome measures (PROMs), using custom or three-dimensional-printed moulds. METHODS: Between January 2019 and March 2024, 64 patients underwent MbBT. All patients were either deemed unsuitable for radical resection or definitive EBRT or refused them. Patients were prospectively enrolled in a database and underwent clinical evaluation at the end of treatment as well as after 30 and 90 days to assess acute and late toxicity. In addition, oncological follow-up and documentation of their quality of life and subjective cosmetic assessment was performed every 6 months thereafter. RESULTS: The median age was 80 years. Histology revealed 19 squamous cell carcinomas, 27 basal cell carcinomas, 2 lesions with both histologies, 9 melanocytic tumours and 7 lesions of other histologies. The median treatment dose was 39 Gy (range 30-45 Gy) at 3 Gy per fraction (range 3-4 Gy), administered once daily at 5 days per week. After a median follow-up of 679 days (interquartile range 361-1049 days), there were seven local recurrences (11%). Thirty-seven patients (58%) rated the cosmetic result as at least good, 23 (36%) rated the treatment as more tolerable than expected, while 16 (25%) rated it as at least bothersome. Apart from one grade 4 cataract, no other grade 4 late toxicity was documented. CONCLUSIONS: High-dose-rate MbBT for CN is an effective and well-tolerated treatment option for older and frail patients who are not eligible for radical surgery or definitive EBRT. The number of people diagnosed with skin tumours is increasing worldwide. At the same time, an ageing population is having a big effect on daily medical practice, creating new challenges – especially when caring for older and frail patients. In addition to surgical resection, local radiotherapy can be a curative option. In cosmetically sensitive regions such as the face, brachytherapy, a special form of radiotherapy, can be used to treat a tumour without harming the surrounding area. We present data on patients who were treated using an innovative brachytherapy technique utilising individualised three-dimensional-printed moulds. This treatment option is safe for older or frail patients and can achieve good local control and cosmetic results.