Daily Cosmetic Research Analysis
An RCT in rhinoplasty shows that sutured scroll ligament reconstruction improves both aesthetic satisfaction and nasal airflow versus no repair. A prospective cohort demonstrates HDR mould-based brachytherapy with custom or 3D-printed applicators achieves good local control and cosmesis in older patients with cutaneous tumors. A methodological study integrates LC-OCT with automated 3D segmentation to quantify dermal fiber changes across age, ethnicity, and skincare use, offering a robust non-inv
Summary
An RCT in rhinoplasty shows that sutured scroll ligament reconstruction improves both aesthetic satisfaction and nasal airflow versus no repair. A prospective cohort demonstrates HDR mould-based brachytherapy with custom or 3D-printed applicators achieves good local control and cosmesis in older patients with cutaneous tumors. A methodological study integrates LC-OCT with automated 3D segmentation to quantify dermal fiber changes across age, ethnicity, and skincare use, offering a robust non-invasive biomarker framework for cosmetic dermatology.
Research Themes
- Optimization of cosmetic surgical techniques and function (rhinoplasty scroll reconstruction)
- Image-based, non-invasive biomarkers for skin aging and product efficacy (LC-OCT with automated 3D segmentation)
- Oncologic skin radiotherapy balancing tumor control and cosmesis (HDR mould-based brachytherapy with 3D-printed molds)
Selected Articles
1. The Effects of Sutured Scroll Reconstruction Versus Sutureless Scroll Reconstruction in Rhinoplasty on Aesthetic and Functional Outcomes: A Randomized Controlled Trial.
In a randomized trial of 164 women undergoing primary rhinoplasty, sutured scroll ligament reconstruction produced higher FACE-Q satisfaction and surgeon-rated aesthetics, and modestly higher peak nasal inspiratory flow versus no repair. No revisions were required over a mean 11.6-month follow-up.
Impact: Provides randomized evidence supporting scroll ligament reconstruction to simultaneously enhance cosmetic and functional outcomes in rhinoplasty, informing technique selection.
Clinical Implications: Supports routine consideration of sutured scroll ligament reconstruction to improve postoperative aesthetic satisfaction and nasal airflow, with objective and patient-reported metrics.
Key Findings
- Sutured scroll ligament repair yielded higher post-operative FACE-Q rhinoplasty satisfaction scores than no repair.
- Independent surgeon VAS aesthetic ratings favored the sutured group.
- Peak nasal inspiratory flow was higher with sutured repair (116.42 ± 13.78 vs 111.08 ± 15.67 ml/min).
- No revision surgeries were required during a mean 11.6-month follow-up.
Methodological Strengths
- Randomized controlled design with balanced baseline characteristics
- Use of validated patient-reported outcome (FACE-Q) and objective functional measures (PNIF/rhinomanometry), plus independent surgeon ratings
Limitations
- Female-only, single-center cohort; blinding not specified
- Clinical significance of the PNIF difference may be modest; incomplete reporting of statistical thresholds in abstract
Future Directions: Multicenter, pre-registered RCTs including male patients with longer follow-up and standardized, blinded aesthetic assessments; quantify airflow and quality-of-life gains and cost-effectiveness.
2. Assessment of dermal fiber changes associated with age ethnicity and cosmetic product use by LC-OCT and automated 3D segmentation.
Using in vivo LC-OCT and an automated 3D segmentation algorithm, the study quantifies dermal fiber remodeling: aging shortens fibers and increases anisotropy; Asian participants show denser networks than Caucasians; anti-aging skincare increases fiber length, node count, and density while reducing anisotropy within 1–3 months.
Impact: Introduces a rigorous, non-invasive imaging biomarker framework to objectively track skin aging and cosmetic product effects, addressing a major measurement gap in cosmetic dermatology.
Clinical Implications: Provides quantifiable endpoints for cosmetic trials and individualized skincare monitoring without biopsy, potentially improving product evaluation and patient counseling.
Key Findings
- Aging was associated with shorter dermal fiber length and increased anisotropy on LC-OCT-based analysis.
- Asian women exhibited a denser dermal fiber network than Caucasian women, with comparable mean fiber length and anisotropy.
- Anti-aging skincare increased fiber length, node count, and network density and reduced anisotropy after 1 and 3 months.
- Automated 3D segmentation of LC-OCT enabled precise, in vivo quantification of dermal fiber metrics.
Methodological Strengths
- High-resolution LC-OCT with in-house automated 3D segmentation enabling objective, in vivo metrics
- Multi-ethnic comparison and longitudinal assessment after cosmetic product use
Limitations
- Sample size and recruitment details not specified; likely single-center
- Lack of randomized control; imaging endpoints are surrogate outcomes without histologic validation
Future Directions: Validate LC-OCT fiber metrics against histology and clinical outcomes in larger, multicenter, randomized studies; standardize algorithms and share annotated datasets to enhance reproducibility.
3. HDR Mould-Based Brachytherapy for Cutaneous Neoplasms: Toxicity, Long-Term Control, Cosmesis and PROMs.
In 64 older or frail patients unsuitable for surgery or definitive EBRT, HDR mould-based brachytherapy using custom/3D-printed moulds achieved 11% local recurrence at a median 679-day follow-up, with 58% rating cosmesis at least good and minimal grade 4 toxicity (one cataract).
Impact: Demonstrates a practical, patient-centered radiotherapy option delivering tumor control with favorable cosmetic outcomes, leveraging individualized 3D-printed moulds in a population with limited alternatives.
Clinical Implications: Supports HDR mould-based brachytherapy as an effective alternative when surgery/definitive EBRT are unsuitable, especially in cosmetically sensitive areas; highlights the need to mitigate ocular risk near periorbital sites.
Key Findings
- Prospective cohort of 64 patients (median age 80) treated with HDR mould-based brachytherapy using custom or 3D-printed moulds.
- Median total dose 39 Gy (3 Gy/fraction); local recurrence rate 11% at median 679 days of follow-up.
- Patient-reported cosmesis rated at least good by 58%; treatment more tolerable than expected in 36%.
- Minimal severe late toxicity observed; one grade 4 cataract reported.
Methodological Strengths
- Prospective data capture with predefined toxicity assessments and longitudinal PROMs
- Use of individualized (including 3D-printed) moulds enabling dose conformity in cosmetically sensitive regions
Limitations
- Single-center, non-randomized design with heterogeneous histologies
- Limited sample size; ocular toxicity signal warrants careful site-specific planning
Future Directions: Conduct controlled comparative trials versus EBRT/surgery, optimize dosing and shielding near ocular structures, extend follow-up for durability, and evaluate cost-effectiveness and quality-of-life outcomes.