Daily Cosmetic Research Analysis

OBJECTIVE: To evaluate the efficacy and safety of oral propranolol (1 mg/kg/day) combined with intralesional bleomycin injections versus propranolol monotherapy at the same dosage for infantile hemangioma (IH). This study investigates if a low-dose propranolol regimen can be enhanced with local therapy to improve outcomes while maintaining a favorable safety profile. METHODS: This single-center, prospective, randomized controlled trial enrolled 260 infants (aged 3-11 months, mean age 5.34 ± 2.57 months) with IH requiring systemic therapy. Participants were randomly assigned (1:1) to either the combination group (propranolol plus monthly intralesional bleomycin, n = 130) or the monotherapy group (propranolol alone, n = 130). The primary efficacy endpoint was the proportion of patients achieving an excellent therapeutic response (complete regression or marked effectiveness) at 6 months. Secondary outcomes included early therapeutic response, changes in hemangioma color score, tumor volume reduction, Vancouver Scar Scale (VSS) scores, and incidence of adverse events. RESULTS: Baseline characteristics were comparable. After 6 months, a significantly higher proportion of patients in the combination group achieved the primary endpoint (77.69% vs. 50.00%; P < 0.001). The combination group had higher rates of complete regression (33.07% vs. 15.38%, P = 0.001) and marked effectiveness (44.61% vs. 34.61%, P = 0.083). A superior early response was noted in the combination group, with a more pronounced degree of tumor atrophy within 24 h (P < 0.001). Post-treatment color scores (change from baseline, P < 0.001) and tumor volume (1.63 ± 0.70 cm CONCLUSION: In infants with IH, augmenting a low-dose oral propranolol regimen (1 mg/kg/day) with monthly intralesional bleomycin is significantly more effective than low-dose propranolol monotherapy. This combination strategy accelerates tumor regression and yields superior cosmetic outcomes, all while maintaining a comparable safety profile.

OBJECTIVE: To compare robotic vs. open thyroidectomy's long-term safety, efficacy, and quality of life for differentiated thyroid cancer. BACKGROUND: Early research showed that robotic thyroid surgery better preserves parathyroid glands and nerves compared to open surgery, but its long-term efficacy and safety remain uncertain. Comparative studies across various extents of thyroidectomy should be enhanced to include long-term follow-up, large sample sizes, and robust evidence from extensive clinical experience. METHODS: This retrospective cohort study included 6,249 patients who underwent open or robotic thyroidectomy in 2014-2024 at a 3:1 ratio (aged 15 to 80 years; 4,659 females and 1,590 males) from a cohort of 11,733 who underwent OT or RT were analyzed. Postoperative complications were recorded, and patients were assessed using quality of life and aesthetic outcome scales. Patients were evaluated using Short Form-36, voice/swallowing/neck impairment scales, and the SCAR-Q questionnaire. Clinical-pathological characteristics, postoperative complications, quality of life, and aesthetic outcome scores were compared. RESULTS: Compared to the robotic thyroidectomy group, the open thyroidectomy group had a higher recurrence rate [135 (2.29%) vs. 29 (1.82%); P = .02], transient and permanent hypoparathyroidism(P < .001) and permanent hoarseness rate(P = .002). The OT group showed a marked decline in RFS probability after 100 months post-surgery, falling below that of the RT group(P = .027). The open thyroidectomy group had higher swallowing and voice impairment scores than the robotic thyroidectomy group (P < .001) and performed worse in physiological function, body pain, general health, vitality, social function, mental health, health change, and SCAR-Q scores (P < .001) after surgery. CONCLUSIONS: Besides its well-recognized cosmetic benefits, robotic thyroidectomy demonstrated superior elegance, effectiveness, and safety across various surgical scopes, significantly enhancing the long-term postoperative quality of life for patients with differentiated thyroid cancer. These findings affirm RT as a valuable surgical option, particularly for those seeking enhanced cosmetic outcomes and requiring complex procedures.

The increasing resistance to chemical pediculicides has raised concerns about the efficacy of head lice treatments, including in Thailand. This study evaluated the efficacy of three commercially available pediculicide shampoos (0.75% permethrin, 0.6% carbaryl, and 0.12% Stemona root crude extract) among infested children in Chonburi Province, Thailand. A pre-test/post-test experimental design was conducted with 135 infested female children assigned to three treatment groups (n = 45 each), with no significant differences in baseline demographic characteristics (level of head lice infestations, hairstyle, and hair length). Each group received two applications (Day 0 and Day 7) of the allocated pediculicide shampoo, following the manufacturer's instructions. The final proportion of cured individuals was assessed on Day 14 after treatment using a fine-tooth comb. The observed percentages of cured individuals were 42.22% for carbaryl shampoo, 24.44% for Stemona shampoo, and 6.67% for permethrin shampoo. No side effects were reported, although none of the shampoos achieved complete eradication, with particularly poor outcomes in children with heavy infestations. These findings provide clinical evidence of reduced efficacy of over-the-counter pediculicides in Thailand, consistent with emerging resistance trends. More effective alternatives with different mechanisms of action, including ivermectin, abametapir, and dimeticone-based products, should be considered, although their current availability in Thailand remains limited. In the interim, development of locally available herbal formulations, together with school-based screening and simultaneous treatment, represents more feasible strategies. These results highlight the need for updated treatment guidelines, restriction of ineffective products, and regular resistance surveillance to ensure effective control.