Daily Cosmetic Research Analysis

Platinum-based materials exhibit diverse biological activities, but their application in skincare is limited by poor targeting and low efficacy in treating inflammation and sensory irritation. Herein, we developed madecassoside-functionalized platinum (Pt-MAD) particles by integrating the bioactive plant-derived compound madecassoside (MAD) with platinum to enhance anti-inflammatory and neurogenic-soothing effects. These Pt-MAD complexes were encapsulated within liposomes to improve dispersion stability and transdermal delivery for dermatological applications. In vitro studies demonstrated that Pt-MAD liposomes outperformed conventional Pt-PVP liposomes in reducing inflammation, itch, and redness. MAD surface functionalization enabled targeted modulation of multiple inflammatory mediators, including TNF-α, IL-1β, and IL-17, thereby promoting rapid soothing while supporting epidermal barrier homeostasis through sustained regulation of neurogenic inflammatory pathways. To explore the underlying mechanism, AI-driven docking simulations were performed, revealing that Pt-MAD exhibited strong binding affinities toward key inflammatory receptors, including TRPV1, TRPA1, NK1R, H1R, ETAR. These findings highlight the therapeutic potential of Pt-MAD liposomes as a targeted and effective strategy for managing sensitive skin, offering rapid relief while supporting barrier homeostasis through IL-17-associated inflammatory modulation.

BACKGROUND: The supraclavicular lateral incision approach offers a promising alternative to the conventional median incision in thyroid surgery, prioritizing cosmetic outcomes and quality of life (QoL) without compromising safety. This study evaluated its efficacy and impact on thyroid-specific QoL in patients undergoing thyroid lobectomy for unilateral papillary thyroid carcinoma (PTC). METHODS: A prospective, nonrandomized study was conducted on 197 PTC patients, including 98 treated with the supraclavicular approach and 99 with the conventional approach. Demographic, clinicopathologic, operative, and postoperative data were collected. Cosmetic satisfaction was assessed at six months post-surgery using visual analog scales, while thyroid-specific QoL was evaluated with the validated T-QoL questionnaire. Statistical analyses compared outcomes between the two groups. RESULTS: Both approaches achieved comparable surgical outcomes, with no significant differences in operation time, blood loss, or complication rates. The supraclavicular approach demonstrated superior cosmetic satisfaction scores for incision scars (median 9 vs. 6, P = 0.001). Although overall T-QoL scores were similar, psychological well-being was significantly better in the supraclavicular group (P = 0.036), with a trend toward improved social well-being (P = 0.066). No recurrences were observed during a median follow-up of 28 months. CONCLUSIONS: The supraclavicular lateral incision approach offers enhanced cosmetic outcomes and mitigates QoL decline without increasing surgical risks. It serves as a feasible, cost-effective alternative to conventional and remote-access techniques, aligning with contemporary trends in minimally invasive thyroid surgery. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Ferulic acid (FA) is a natural polyphenolic compound that has garnered significant attention due to its exceptional antioxidant, anti-inflammatory, and anticancer bioactivities. However, its poor chemical stability, low solubility, and insufficient bioavailability in practical applications severely limit its widespread use in the food, pharmaceutical, and cosmetics industries. To improve the stability and bioavailability of FA, this study used rice starch (RS), debranched starch (DBS) and soluble starch (SS) modified with octenyl succinic anhydride (OSA) as carriers to prepare three FA complexes, with the aim of improving their solubility and stability. The antioxidant activity, stability, and in vitro release behavior of the encapsulated FA were evaluated. Experimental results indicated that the encapsulation mechanism of ferulic acid by starch-based carriers involves hydrogen bonding, van der Waals force, and hydrophobic interactions. OSA-DBS exhibited the highest encapsulation efficiency, attributed to its compact cavity spiral structure. At the same time, OSA-SS and OSA-RS had lower encapsulation efficiencies due to their loose structure and mixed crystalline-amorphous structure, respectively. FA@OSA-DBS exhibited the strongest antioxidant activity and antibacterial ability, with significantly improved solubility and stability. In vitro release studies showed that FA@OSA-DBS exhibited a slow release rate in a simulated physiological environment, following a first-order kinetic model. The results indicate that the preparation of FA complexes using esterified starch can significantly improve the physical and chemical properties of FA by regulating the interfacial characteristics of starch. This finding lays the theoretical foundation for the development of phenolic acid-starch composite systems in the field of functional materials.