Daily Cosmetic Research Analysis

BACKGROUND: The human umbilical cord (hUC)-mesenchymal stem cell (MSC) secretome (SCT) is a cell-free therapy that may emerge as a novel therapeutic strategy for hair loss prevention. Here, we aimed to elucidate the underlying mechanisms through which SCT regulates hair growth and cycle transition. METHODS: Using C57BL/6 mice, ex vivo follicles, and cell experiments, we studied the effects and mechanisms of SCT on hair growth and cycling using untargeted metabolomics and phosphoproteomics. A three-month double-blind clinical study was conducted to validate the effects of SCT on human hair. RESULTS: SCT promotes the telogen-to-anagen transition, hair thickening, and elongation of the vibrissae in mice; regulates dermal papilla cells and hair matrix cells through cysteine and methionine metabolism; and stimulates methylthioadenosine synthesis in hair matrix cells by activating the PI3K/AKT/mTOR signaling pathway. Clinical studies demonstrated that SCT increased human hair density and average hair diameter. Scalp physiological tests and subjective feedback indicated no related adverse reactions on the scalp or hair. CONCLUSIONS: SCT promoted hair growth, thickening, and the hair follicle cycle via the PI3K/AKT/mTOR signaling pathway. This research provides a basis for the application of cell-free alternatives in hair care and hair loss prevention.

BACKGROUND: Before primary rhinoplasty, it is crucial to identify patients whose concerns may not be adequately addressed by surgery. In 1999, Gorney and Martello introduced SIMON to describe patients who may be unsatisfied: single, immature, male, overly expectant, and narcissistic. This paper advocates for an evidence-based mnemonic to enhance patient selection. METHODS: TriNetX database medical records were queried for patients who underwent primary rhinoplasty at least three years ago at ≥ 15 years old. A Cox proportional hazards model quantified relationships between 115 patient variables, including SIMON-like characteristics, and risk of revision rhinoplasty. RESULTS: Of 101,562 patients, more female patients underwent revision rhinoplasty than male patients (p = 0.062). Revision risk was 16.8× higher with social exclusion/rejection; 5.36× higher with personality disorders; 3.45× higher with history of subcutaneous filler injections; 2.64× higher with anxiolytic or sedative dependence; 1.38× higher with male sex; and 1.16× higher with anxiolytic use. "Married" relationship status, BMI > 30, older age at surgery, and diagnosed deviated septum were negative associations with revision rhinoplasty. CONCLUSION: In the current day, additional nuance in social relationships, surgical history, psychiatric diagnosis, and surgical indication may be required to predict revision rhinoplasty. We propose an acronym, BLAKE: Borderline/personality disorders, Lonely/social exclusion, Anxiolytics/sedatives, Kosmetik focus, and previous Enhancement with fillers. BLAKE captures the most salient predictors of revision at the time of primary rhinoplasty, updating the SIMON acronym to be non-gendered and nonreligious. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

BACKGROUND: Cosmetic products are widely used today and are often associated with a healthy lifestyle. However, their widespread application and the presence of potentially toxic substances have raised increasing concerns regarding their impact on human health. Among these substances, metals are particularly hazardous due to their ability to penetrate the skin and cause adverse health effects, even at very low concentrations. Therefore, the development of novel and reliable methodologies for the determination of trace metals in cosmetics is of great importance for ensuring product safety. RESULTS: A new analytical method based on a magnetic eutectic mixture (MEM) ultrasound-assisted emulsification-micro-extraction (USAEME) followed by inductively coupled plasma optical emission spectrometry (ICP OES) for trace metals in cosmetics has been developed. The extraction procedure was optimized using a multivariate approach. The method was evaluated under optimized extraction conditions (i.e., sample mass, 11 g; MEM volume, 59 μL; extraction time, 3 min and ultrasound as dispersive mode). Limits of detection from 0.05 to 5.4 μg kg SIGNIFICANCE: A novel, rapid, sensitive, and environmentally sustainable method was developed for the simultaneous determination of Al, Cd, Cr, Cu, Mn, Pb, and Zn in essential oil samples using ICP OES. The methodology incorporated a preconcentration step via USAEME employing a new designed Co-based MEM (i.e., cobalt (II) chloride hexahydrated:ethylene glycol, 1:2).