Daily Cosmetic Research Analysis

Skin, the body's largest organ, is a critical barrier that often faces damage. Among different collagen types, collagen XVII (COL17) is a distinctive type that uniquely supports skin adhesion and integrity, anchoring the epidermis to the dermis and facilitating wound healing. Our previous study has shown powerful skin repair and regeneration abilities of recombinant human COL17 (rhCOL17). However, its impact on the epidermal stem cells and how this effect influences the skin repair and regeneration remains largely unknown. In this study, using ablative fractional laser skin injury and UVB radiation - induced photoaging models, we first revealed that 0.1% rhCOL17 is optimal for skin repair, which can reduce epidermal thickness and restore skin conditions with increased proliferation of epidermal stem cells. More importantly, our results indicated that rhCOL17 could stimulate the proliferation of Lgr6-positive epidermal stem cells. We also investigated the underlying molecular mechanisms and found that rhCOL17 activates the expression of Lgr6, thereby upregulating the downstream Wnt/β-catenin pathway that ultimately promote skin repair and regeneration. This study provides new insights into the therapeutic applications of rhCOL17 for skin disorders and injuries and offers a promising strategy for improving clinical outcomes in dermatological practice.

BACKGROUND: This study compared the efficacy of a bioflavonoid-enriched herbal mouthwash versus 0.12% and 0.2% chlorhexidine (CHX) in reducing peri-implant inflammation and subgingival Porphyromonas gingivalis (P. gingivalis) carriage among patients with peri-implantitis. METHODS: In all, 67 individuals diagnosed with peri-implantitis were enrolled. Demographic and implant-related data were retrieved, and subgingival biofilm samples were analysed for P. gingivalis. All patients underwent non-surgical mechanical debridement (MD) and were then randomised into three groups: test group (bioflavonoid mouthwash, n = 22), control group 1 (0.12% CHX, n = 23), and control group 2 (0.2% CHX, n = 22). Participants rinsed with 15 ml of the assigned solution twice daily for 90 days. Clinical parameters, including modified plaque index (mPI), modified bleeding index (mBI), probing depth (PD), and crestal bone loss, were recorded at baseline and after 90 days. Statistical significance was set at P < 0.05. RESULTS: Significant reductions in mPI, mBI, and PD were observed across all groups compared with baseline (P < 0.05). The follow-up scores for these parameters were significantly lower in the test group compared with both CHX groups (P < 0.05). At baseline, P. gingivalis was detected in 79.1% of participants. After 90 days, P. gingivalis carriage was lower in the test group (13.6%) compared with control group 1 (50.0%) and control group 2 (54.5%). CONCLUSION: Prescription of a bioflavonoid-enriched herbal mouthwash following MD is more effective in reducing peri-implant inflammation and subgingival P. gingivalis compared with 0.12% and 0.2% CHX rinses.

Sensitive skin is characterised by unpleasant skin sensations in response to normally non-provocative stimuli. While its pathophysiology remains incompletely understood, environmental factors and impaired barrier function are key contributors. Because many of these environmental factors also promote extrinsic skin aging, a link between sensitive skin and skin aging phenotypes has been proposed. To examine this hypothesis, we analysed data from 810 participants of the Chinese Taizhou Longitudinal Study (2012-2014). Sensitive skin was classified into subtypes based on questionnaire responses, and skin aging phenotypes were assessed using a subset of items from the SCINEXA (Score of Intrinsic and Extrinsic Skin Aging). Associations between sensitive skin subtypes and specific skin aging phenotypes were examined using multivariate regression models. Environmentally triggered sensitive skin was associated with the presence of pigment spots on the cheeks in participants aged ≥ 50 years, particularly among women. Intrinsically triggered sensitive skin was associated with perioral wrinkles, again most prominently in older women. This is the first large-scale study demonstrating objective associations between sensitive skin subtypes and specific skin aging phenotypes. The findings identify subpopulations potentially more vulnerable to environmental stressors, underscoring the need for targeted prevention strategies.