Daily Cosmetic Research Analysis
Analyzed 2 papers and selected 2 impactful papers.
Summary
Two studies relevant to cosmetic science were identified: an international expert consensus standardizing clinical use of artificial iris implantation for functional and cosmetic rehabilitation, and a preclinical comparison of green extraction methods for silver fir-derived antioxidants with potential cosmeceutical applications. The consensus offers actionable surgical and perioperative guidance, while the extraction study supports subcritical water extraction at 100°C to maximize bioactive content with low cytotoxicity.
Research Themes
- Aesthetic and functional ophthalmic reconstruction
- Consensus-driven surgical standardization
- Green extraction of cosmetic antioxidants
Selected Articles
1. Expert Consensus on the Clinical Application of Artificial Iris.
An international Delphi-based consensus synthesizes evidence to standardize artificial iris implantation across six domains: indications/contraindications and device selection, surgeon–patient communication, surgical principles/critical techniques, perioperative care, and long-term complication management. The guidance aims to improve safety, visual function, and cosmetic outcomes for patients with iris defects.
Impact: Provides the first comprehensive, evidence-informed consensus to unify global practice for artificial iris implantation, directly addressing safety and outcome variability.
Clinical Implications: Offers standardized criteria and perioperative protocols that can reduce complications, enhance patient counseling, and optimize functional and cosmetic outcomes in artificial iris implantation.
Key Findings
- Defined six evidence-based domains for artificial iris implantation, including indications/contraindications and device selection.
- Outlined surgeon–patient communication essentials and surgical principles with critical techniques.
- Specified perioperative care protocols and strategies to manage long-term postoperative complications.
Methodological Strengths
- Systematic literature search underpinning a structured Delphi process with 18 international experts
- Iterative evidence integration and consensus refinement across predefined core clinical issues
Limitations
- Consensus-based recommendations without prospective comparative clinical trials
- Heterogeneity of source evidence and potential publication bias limit certainty
Future Directions: Prospective multicenter studies and registries to validate safety, functional, and cosmetic outcomes under the standardized protocol; comparative trials across device types and techniques.
OBJECTIVE: To establish evidence-based guidance to standardize the clinical application of artificial iris implantation in patients with iris defects. METHODS: A systematic literature search was performed following evidence-based consensus development standards. Eighteen international experts participated in a Delphi process to define six core clinical issues. Evidence was screened, extracted, evaluated and integrated. Recommendations were formulated through iterative expert review. RESULTS: We established six key clinical issues related to artificial iris implantation and evidence-based recommendations to address critical gaps in clinical practice. Key outcomes included standardized criteria for indications, contraindications, and type of artificial iris selection, key aspects of surgeon-patient communication, surgical management principles and critical techniques, comprehensive perioperative care protocols, and strategies for managing long-term postoperative complications associated with artificial iris implantation. CONCLUSIONS: This consensus standardizes artificial iris implantation through six evidence-based recommendations. It provides a standardized protocol for safe clinical implementation to restore visual function and cosmetic integrity in patients with iris defect.
2. Exploring techniques for extraction of silver fir (
Comparative extraction of silver fir bark and branches identified subcritical water extraction at 100°C (SWE-BA-100) as optimal, yielding the highest total phenolics, lignans (notably secoisolariciresinol), and antioxidant activity, with non-cytotoxic profiles. Bark extracts outperformed branches in bioactivity, though branches provided higher yields; SWE-BA-100 inhibited cell migration, warranting further safety evaluation for cosmetic applications.
Impact: Establishes an environmentally friendly extraction condition that maximizes antioxidant constituents from silver fir, informing development of cosmeceutical ingredients.
Clinical Implications: Provides preclinical evidence to guide sourcing and processing of plant-derived antioxidants for cosmetic formulations, while highlighting the need to evaluate effects on cell migration.
Key Findings
- Subcritical water extraction at 100°C (SWE-BA-100) of bark maximized total phenolics (73.8 mg GAE/g), lignans (secoisolariciresinol 204.7 µg/mL), and antioxidant activity (DPPH 24.2, ABTS 32.0 mg GAE/g).
- Bark extracts showed superior bioactive profiles compared to branches, while branch extractions yielded higher overall extract amounts.
- All extracts were non-cytotoxic under tested conditions; SWE-BA-100 inhibited cell migration, indicating complex bioactivity requiring further assessment.
Methodological Strengths
- Head-to-head comparison of extraction techniques and plant parts with temperature gradient in subcritical water extraction
- Multi-assay antioxidant profiling (e.g., DPPH, ABTS) combined with cytotoxicity and cell migration assessments
Limitations
- Preclinical in vitro design without in vivo or clinical validation
- Title and method details truncated in available record; incomplete reporting of supercritical CO2 parameters
Future Directions: Validate bioactivity and safety in skin-relevant in vitro models (e.g., keratinocytes, fibroblasts) and in vivo; standardize SWE parameters and assess stability and efficacy in cosmetic formulations.
CONTEXT: Silver fir ( OBJECTIVE: To compare extraction techniques and identify the optimal method for obtaining high-quality silver fir extracts with strong antioxidant activity and minimal cytotoxicity. MATERIALS & METHODS: Extracts from bark and branches were prepared using subcritical water extraction (SWE, 70-200 °C), supercritical CO RESULTS: The SWE bark extract at 100 °C (SWE-BA-100) showed the highest TPC (73.8 mg GAE/g), lignan content (secoisolariciresinol 204.7 µg/mL), and antioxidant activity (DPPH: 24.2, ABTS: 32.0 mg GAE/g). Bark extracts had superior bioactive profiles compared to branches, though branch extractions gave higher yields. All extracts were non-cytotoxic. SWE-BA-100 inhibited cell migration, indicating a complex interaction between composition and cellular response. DISCUSSION AND CONCLUSION: SWE at 100 °C is a promising green method for producing potent antioxidant extracts from