Daily Cosmetic Research Analysis
Analyzed 9 papers and selected 3 impactful papers.
Summary
Analyzed 9 papers and selected 3 impactful articles.
Selected Articles
1. Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy.
The authors engineered a hybrid biomembrane-coated black phosphorus nanosheet system (MM@BPPF) delivering sequential therapeutic agents to restore neuronal mitochondrial function and modulate microglia after ischemia. Intranasal administration bypassed the BBB and increased brain/mitochondrial targeting, demonstrating therapeutic benefit in ischemia-reperfusion models.
Impact: Provides a novel, translational delivery strategy combining inflammation- and mitochondria-targeting with BBB bypass — a significant advance toward clinically relevant neuroprotective therapies.
Clinical Implications: If validated in larger preclinical and early-phase clinical studies, this approach could enable noninvasive intranasal therapies to limit ischemic brain injury by restoring mitochondrial function and modulating neuroinflammation.
Key Findings
- MM@BPPF combines microglia- and mitochondria-derived membranes on black phosphorus nanosheets loaded with PolyMet and FTY720.
- Intranasal administration bypasses the BBB and increases accumulation in injured brain regions and neuronal mitochondria.
- Sequential actions of BP NSs, PolyMet, and FTY720 restore mitochondrial function and modulate microglial polarization, improving outcomes in ischemia-reperfusion models.
Methodological Strengths
- Multimodal engineering combining biomimetic membranes with nanosheet carriers and multiple therapeutic agents.
- Use of intranasal delivery with in vivo models demonstrating enhanced targeting and functional outcomes.
Limitations
- Translation to humans remains untested; safety, dosing, and long-term effects of BP NSs and membrane coatings require study.
- Potential immunogenicity or off-target effects of hybrid biomembranes were not fully characterized.
Future Directions: Advance to rigorous preclinical toxicology and biodistribution studies, optimize dose/regimen, and pursue early-phase clinical trials to test safety and proof-of-concept in stroke patients.
Mitochondrial damage constitutes the central pathological mechanism of cerebral ischemia-reperfusion (I/R) injury. Targeted delivery of antioxidants to mitochondria and the phenotype polarization of glial cells holds great promise for effective treatment. However, the blood-brain barrier (BBB) remains a major obstacle, causing insufficient drug accumulation in neuronal mitochondria. Here, we develop a bioengineered nanolamellar system (MM@BPPF) by coating microglia-mitochondria hybrid biomembrane onto black phosphorus nanosheets (BP NSs) loaded with polymetformin (PolyMet) and fingolimod hydrochloride (FTY720). Microglia membrane facilitates inflammation-directed targeting to the injured brain regions, while mitochondria membrane confers homotypic targeting to mitochondria. Meanwhile, BP NSs, PolyMet, and FTY720 act sequentially to restore mitochondrial function of neuronal cells and modulate microglial polarization. Intranasal administration enables MM@BPPF to bypass the BBB, substantially improving brain-targeting efficiency. This work not only offers an innovative sequential targeting strategy for mitigating I/R injury but also presents a potential paradigm for treating other central nervous system disorders.
2. Chemical composition, metabolomics, and functional potential of Pholiota nameko pre-cooking liquid.
The study shows that Pholiota nameko pre-cooking liquid retains and concentrates substantial amounts of polysaccharides, proteins, polyphenols, minerals and distinct metabolites; untargeted metabolomics identified several upregulated compounds, supporting valorization for food, cosmetic, pharmaceutical and agricultural uses while reducing waste disposal.
Impact: Demonstrates a sustainable, data-driven route to convert an industrial waste stream into value-added ingredients with multi-sector applications including cosmetics, aligning with circular economy goals.
Clinical Implications: Indirect for clinical practice; primary implications relate to formulation of natural cosmetic or topical products and potential nutraceutical applications pending safety/toxicity testing.
Key Findings
- Pre-cooking liquid contains transferred fractions: ~7.99% polysaccharides, 41.04% proteins, and 62.96% polyphenols from fruiting bodies.
- Untargeted UHPLC-ESI-MS/MS metabolomics identified significant upregulation of Ethyl isopropyl sulfide, Vidarabine, 5-oxoproline, and Picolinic acid in the liquid.
- The liquid exhibits favorable physicochemical properties and low pesticide residues, supporting applications as nutritional/flavor/thickening agents and in cosmetics/pharmaceuticals.
Methodological Strengths
- Comprehensive chemical and untargeted metabolomics profiling (UHPLC-ESI-MS/MS) combined with standard compositional analyses.
- Quantitative assessment of transfer rates from fruiting bodies to liquid and evaluation of pesticide residue levels.
Limitations
- Functional bioactivity assays for cosmetic or therapeutic effects were not presented; biological activity must be confirmed.
- Scale-up, purification, stability, and safety (e.g., allergenicity, dermal toxicity) under regulatory contexts require further study.
Future Directions: Perform targeted bioactivity and safety assays (dermal irritation, sensitization), formulate prototype cosmetic/food products, and pilot-scale extraction with life-cycle/environmental impact assessment.
The liquid generated during the pre-cooking process of Pholiota nameko is frequently considered waste, and its large-scale disposal may pose environmental risks. This study undertook a comparative analysis of the liquid and the fruiting bodies, focusing on their chemical composition, physicochemical properties, and metabolomics. Standard chemical analysis methods were applied to determine the levels of key components (e.g., polysaccharides, proteins, amino acids) and their physicochemical properties. Meanwhile, untargeted metabolomics based on UHPLC-electrospray ionization mass spectrometry/mass spectrometry (UHPLC-ESI-MS/MS) was utilized for systematic metabolite identification and comparison. The results demonstrate that immersing the fruiting bodies in water at 95 °C for 10 min facilitates the transfer of substantial quantities of compounds into the liquid, with approximately 7.99% of polysaccharides, 41.04% of proteins, and 62.96% of polyphenols in the fruiting bodies being transferred. This liquid is abundant in minerals and functional components, exhibits distinctive physicochemical properties, and holds potential as a natural nutritional enhancer, flavor enhancer, and thickener, with pesticide residue levels remaining within safe limits. Metabolomic data revealed that the pre-cooking treatment significantly altered the metabolite profile. Specifically, several compounds were substantially upregulated in the pre-cooking liquid compared to the fruiting bodies: Ethyl isopropyl sulfide (7.96-fold), Vidarabine (7.41-fold), 5-oxoproline (3.92-fold), and Picolinic acid (2.48-fold). These changes are associated with alterations in the metabolism of vitamins, peptides, and nucleic acids. The research establishes a chemical and metabolic basis for the advanced development and application of P. nameko pre-cooking liquid across various sectors, including food, pharmaceuticals, health products, cosmetics, and agricultural fertilizers. This study presents an innovative approach to addressing the environmental discharge challenges associated with this substance.
3. Dual-emission fluorescent ZnS nanosheets for sensitive detection of carcinogenic Sudan dyes in chili powder and lipstick samples.
Developed a solvothermally synthesized 2D ZnS nanosheet dual-emission fluorescent probe that rapidly (≤20 s) and sensitively detects Sudan III/IV in complex matrices including chili powder and lipstick via inner filter effect quenching, with broad pH tolerance and high selectivity.
Impact: Provides a rapid, sensitive, and practical analytical tool for detecting carcinogenic dyes in cosmetic products (e.g., lipstick), directly addressing consumer safety and regulatory monitoring needs.
Clinical Implications: Indirect clinical impact: improves public health protection by enabling better surveillance and removal of contaminated cosmetic products, thereby reducing exposure risk to carcinogens.
Key Findings
- ZnS nanosheets exhibit stable dual fluorescence peaks at 521 and 557 nm with photobleaching resistance.
- Fluorescence quenching by Sudan dyes via inner filter effect enables rapid detection within 20 seconds across pH 2–10.
- High selectivity and reproducibility in chili powder and lipstick matrices with low detection limits (reported values in nmol L^-1 range).
Methodological Strengths
- Use of 2D nanosheet morphology to improve surface accessibility and reduce aggregation compared with conventional nanoparticles.
- Validation in real-world complex matrices (food and cosmetic samples) demonstrating practical applicability.
Limitations
- Potential matrix effects beyond tested sample types (other cosmetic formulations) need evaluation.
- Long-term stability, inter-batch reproducibility of nanosheet synthesis, and scalability for routine regulatory use require further validation.
Future Directions: Extend validation to a wider range of cosmetic formulations, standardize nanosheet synthesis for routine laboratory use, and develop portable assay formats for field/regulatory monitoring.
Sudan dyes are carcinogenic colorants illicitly added to foods and cosmetics, posing serious health risks. Herein, a rapid dual-emission fluorescent probe based on two-dimensional (2D) ZnS nanosheets is developed for sensitive detection of Sudan dyes (III/IV). Compared with conventional nanoparticles, the nanosheet structure offers high surface accessibility, excellent dispersion, and reduced aggregation, enabling reliable sensing in complex matrices. The ZnS nanosheets (NS), synthesized via the solvothermal method, exhibit stable fluorescence emissions at 521 and 557 nm with photobleaching resistance. Fluorescence quenching by Sudan dyes is governed by the inner filter effect, allowing a rapid response within 20 s over a broad pH range (2-10). The probe shows high selectivity and reproducibility, with detection limits of 339/436 nmol L