Daily Cosmetic Research Analysis
Analyzed 24 papers and selected 3 impactful papers.
Summary
Analyzed 24 papers and selected 3 impactful articles.
Selected Articles
1. Emerging advances in non-surgical ablation for early-stage breast cancer.
This review synthesizes clinical evidence showing that radiofrequency ablation and cryoablation can achieve high complete ablation rates, favorable safety, and excellent cosmetic outcomes for small early-stage breast cancers. It also details Japan’s 2023 reimbursement approval for RFA, framing regulatory and surveillance needs for broader adoption.
Impact: Ablation could reduce surgical morbidity and improve cosmesis in select early breast cancers; the Japanese reimbursement milestone signals real-world translational impact and a path to guideline integration.
Clinical Implications: For small, early-stage tumors, image-guided ablation may be considered in specialized centers with standardized imaging-pathology correlation and rigorous post-ablation surveillance; shared decision-making should weigh oncologic control against cosmetic benefits.
Key Findings
- RFA and cryoablation achieve high complete ablation rates with favorable safety and excellent cosmetic outcomes in small early-stage breast cancers.
- Single-arm prospective trials report up to 5-year follow-up, supporting durability of local control.
- RFA received insurance coverage approval in Japan in December 2023, with outlined regulatory pathways.
Methodological Strengths
- Integrates multi-study clinical evidence including 5-year prospective follow-up data.
- Frames regulatory and implementation context relevant to health system adoption.
Limitations
- Narrative review without meta-analysis; evidence largely from single-arm studies.
- Lack of randomized controlled trials limits definitive oncologic equivalence claims.
Future Directions: Conduct randomized trials versus lumpectomy, standardize imaging-pathology correlation, and establish surveillance protocols and registries to validate long-term oncologic and cosmetic outcomes.
Recent advances in diagnostic imaging have led to an increase in the detection of early-stage breast cancer, prompting growing interest in minimally invasive breast surgery. These approaches include the omission of axillary lymph node dissection, use of endoscopic or robot-assisted surgery, and application of non-surgical ablation techniques. Non-surgical ablation therapy aims to eradicate tumor tissue in situ by delivering localized thermal or cryogenic energy under imaging guidance without surgical resection. Among these, radiofrequency ablation (RFA) and cryoablation have been the most extensively studied, showing promising results for small early-stage tumors. Clinical studies have reported high rates of complete tumor ablation, favorable safety profiles, and excellent cosmetic outcomes. Moreover, single-arm prospective trials have provided 5-year follow-up data, offering valuable insights into long-term efficacy. Despite these encouraging results, non-surgical ablation has not been internationally adopted as a standard treatment because of concerns regarding oncological surveillance and outcome validation. However, in Japan, RFA for early-stage breast cancer was approved for insurance coverage in December 2023. This review summarizes the current trends and clinical evidence for RFA and cryoablation, and discusses the regulatory pathways required for RFA insurance approval in Japan.
2. Dynamic Eyelid Evaluation Using a Deep Neural Network in Upper Blepharoplasty: A Prospective Multicenter Pilot Study.
In a prospective multicenter pilot, a deep neural network accurately quantified eyelid parameters after blepharoplasty, with ICCs ≥0.965 versus manual measures. Dynamic changes over long-term follow-up aligned with high FACE-Q satisfaction and a strong negative correlation between pre-tarsal show and satisfaction.
Impact: Provides objective, reproducible AI metrics for blepharoplasty outcomes, enabling standardized assessment and data-driven revision planning in a common cosmetic surgery.
Clinical Implications: Surgeons can integrate AI-derived eyelid metrics into routine follow-up to benchmark outcomes, guide revisions, and improve patient counseling with FACE-Q-aligned targets.
Key Findings
- Automated DNN measurements strongly agreed with manual assessments for pre-tarsal show, corneal visibility ratio, and dynamic value (ICCs 0.965–0.975).
- Over long-term follow-up, pre-tarsal show and crease depth decreased, while corneal visibility ratio and dynamic value increased.
- FACE-Q satisfaction was high (87.6) and negatively correlated with pre-tarsal show (r = -0.814, p = 0.000).
Methodological Strengths
- Prospective multicenter design with standardized imaging and video acquisition.
- Objective AI pipeline with high intraclass correlation to manual gold-standard measurements.
Limitations
- Pilot-scale sample and focus on revisional cases may limit generalizability to primary blepharoplasty.
- Exact duration of long-term follow-up not specified; external validation across devices and ethnicities needed.
Future Directions: Validate models in larger, multi-ethnic primary blepharoplasty cohorts, release code/data for reproducibility, and integrate metrics into perioperative decision-support.
BACKGROUND: Upper blepharoplasty is the most common cosmetic procedure in East Asia. A natural Asian double eyelid features specific crease characteristics. AI advancements, such as UNet and PointRend, enhance medical image segmentation, aiding in post-blepharoplasty evaluation. This study applies deep neural networks to analyze facial images, providing morphological parameters to assist surgeons in assessing outcomes and planning revisions. METHODS: This study included 102 eyes from 51 patients seeking for revisional blepharoplasty and 100 eyes from 50 volunteers with inborn double eyelid. Standardized images and videos were collected. The deep learning-based image analysis automatically evaluated four eyelid morphological parameters, including pre-tarsal show, corneal visibility ratio, dynamic value, and crease depth. Analysis was done on the agreement between the automated measures and the manual measurements. The parameters of the patients' and volunteers' eyelids were compared. FACE-Q surveys were used to measure patient-reported esthetic outcomes. RESULTS: The intraclass correlation coefficients between manual measures and automated measurements of pre-tarsal show, corneal visibility ratio, and dynamic value were 0.973, 0.975, and 0.965. At the long-term follow-up, the pre-tarsal show and crease depth decreased significantly, whereas the corneal visibility ratio and dynamic value increased significantly. FACE-Q scores demonstrated a high level of patient satisfaction for facial appearance (87.6) and were negatively correlated with pre-tarsal show (r = - 0.814, p = 0.000). CONCLUSIONS: The deep neural network technique automatically measured the eyelid morphology with excellent precision and reproducibility, enabling an objective evaluation of the surgical outcomes for blepharoplasty. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
3. Ten Years of Patch Testing to Hydroperoxides of Limonene and Linalool: Prevalence, Patterns and Clinical Insights.
A 10-year registry of 6,719 consecutively patch-tested patients showed positive rates of 1.6% for limonene hydroperoxides and 3.1% for linalool hydroperoxides, with most reactions weakly positive and peaking at day 3/4. Doubtful infiltrated reactions progressed to positive more than erythematous-only, co-reactivity with other fragrance allergens was common, and current test concentrations appear optimal.
Impact: Large-scale, decade-long real-world data refine interpretation of doubtful reactions, confirm co-reactivity, and support inclusion of these allergens at specific concentrations in baseline series—directly informing clinical testing and regulation.
Clinical Implications: Include limonene and linalool hydroperoxides in baseline series, interpret doubtful infiltrated reactions with caution, and maintain recommended concentrations (0.3% and 1.0%) to balance sensitivity and specificity.
Key Findings
- Positive patch test prevalence: 1.6% for limonene hydroperoxides and 3.1% for linalool hydroperoxides in 6,719 patients.
- Most reactions were weakly positive and peaked on day 3/4; doubtful infiltrated reactions progressed to positive more often than erythematous-only.
- Co-reactivity with other fragrance allergens was observed; lower concentrations reduced diagnostic sensitivity and current concentrations appear optimal.
Methodological Strengths
- Large, consecutive patient registry over 10 years with standardized patch test reading days.
- Clinical subclassification of doubtful reactions enabling nuanced interpretation.
Limitations
- Single-center retrospective design may limit generalizability.
- Causality between positive tests and clinical dermatitis not fully delineated in the abstract.
Future Directions: Multi-center validation, exposure assessment linking patch test positivity to clinical relevance, and evaluation of test concentrations across demographics.
BACKGROUND: Limonene and linalool are widely used fragrances in cosmetic and household products. Upon air exposure, they autoxidise into potent sensitisers - hydroperoxides of limonene (Lim-OOH) and linalool (Lin-OOH). OBJECTIVES: The objective of this study is to investigate patch test reactions to Lim-OOH and Lin-OOH, and associated characteristics, reaction patterns, including doubtful reactions and co-reactivity with other fragrance allergens. METHOD: A retrospective analysis was conducted using registry data from 6719 consecutively patch-tested patients at Gentofte Hospital, Denmark (2014-2025). Doubtful reactions were clinically subclassified as erythematous, only (E) or infiltrated (I). RESULTS: The prevalence of positive patch test reactions was 1.6% for Lim-OOH and 3.1% for Lin-OOH. Positive Lim-OOH reactions were less likely in men and in patients with atopic, occupational or hand dermatitis, whilst positive Lin-OOH reactions were more likely in those > 40 years and less in atopic dermatitis. Most reactions peaked on day 3/4 and were weakly positive. Doubtful I reactions more frequently progressed to positive than doubtful E. Co-reactivity was observed between Lim-OOH, Lin-OOH and other fragrance allergens. Lower test concentrations reduced diagnostic sensitivity. CONCLUSION: Co-reactivity with other fragrance allergens supports true allergenicity. The currently recommended patch test concentrations (0.3% Lim-OOH and 1.0% Lin-OOH) seem optimal and qualify for inclusion in the European baseline series.