Daily Cosmetic Research Analysis

The skin is a tissue highly susceptible to damage from various stressors, including reactive oxygen species, UV radiation and chemical exposure. While damaged cells are often repaired, some sustain irreversible damage and become senescent. Although the body possesses mechanisms to remove these senescent cells, they accumulate with age for reasons that remain unclear. The close relationship between chronic inflammation and cellular senescence has recently become a major focus of research. Here, we sought to analyse the mechanisms driving age-related chronic inflammation and its impact on the accumulation of senescent cells. Our analysis of the cytokine IL-17A, a key factor in chronic inflammation, revealed that its levels increase in the skin with age. We also discovered that regulatory T cells (Treg cells), which typically act to suppress IL-17A, begin to secrete it as they age. Moreover, we found that IL-17A enhances the resistance of senescent cells to apoptosis. These results propose a model in which the age-related rise in the inflammatory factor IL-17A fosters an environment where senescent cells resist clearance, thereby promoting their accumulation.

BACKGROUND: This study aimed to summarize the current clinical evidence, technical advances, and practical insights related to robotic thyroidectomy using the da Vinci SP (Single-Port) surgical system, with an emphasis on the evolution of surgical approaches and outcomes based on the author's institutional experience and literature review.

METHODS: A focused narrative review of studies published between 2019 and 2025 was conducted to evaluate the safety, feasibility, and clinical performance of single-port robotic thyroidectomy. Five representative SP approaches (single-port transoral robotic thyroidectomy [SP-TORT], single-port transaxillary robotic thyroidectomy [SP-TART/START], retroauricular approach using the da Vinci SP system [RA-SP], single-port robotic areolar approach [SPRA], and gas-insufflation one-step single-port transaxillary [GOSTA]) were compared in terms of operative technique, ergonomics, and postoperative outcomes.

RESULTS: Across multiple institutions, SP robotic thyroidectomy demonstrated operative times, complication rates, and lymph node yields comparable to those of conventional multi-port or open surgery while providing distinct cosmetic and ergonomic advantages. Transient recurrent laryngeal nerve palsy and hypocalcemia were the most common complications, with low overall morbidity. Recent reports have extended the SP technology to modified radical neck dissection (MRND) through the START, SPRA, and GOSTA approaches, confirming the oncologic feasibility of comprehensive nodal dissection within a confined workspace.

CONCLUSION: The da Vinci SP system represents a meaningful advancement in minimally invasive endocrine surgery by enabling single-port robotic thyroidectomy through various remote-access approaches. Current evidence supports its safety, feasibility, and favorable cosmetic outcomes when applied to appropriately selected patients. However, further refinement of instrumentation, optimization of surgical techniques, and accumulation of long-term clinical data are required to expand its indications and to define its role in advanced thyroid diseases more clearly.

BACKGROUND Fat-dissolving (lipolysis) injections are increasingly performed as non-surgical aesthetic procedures for body contouring. Although generally considered safe, these interventions can rarely result in severe and potentially life-threatening complications, especially in unregulated settings. We report an unusual case of acute respiratory distress syndrome (ARDS) following cosmetic lipolysis injections in a previously healthy woman. CASE REPORT A 41-year-old Vietnamese woman with no significant past medical history developed acute progressive dyspnea and bilateral chest pain about 30 minutes after receiving multiple abdominal, shoulder, and thigh lipolysis injections at an unlicensed cosmetic facility. Chest computed tomography showed diffuse bilateral infiltrates. Pulmonary embolism and macroscopic fat embolism were excluded; however, microscopic intravascular fat embolism could not be definitively ruled out. The patient's condition rapidly progressed to hypoxemic respiratory failure consistent with ARDS. Management with high-flow nasal cannula oxygen, intravenous corticosteroids, and empiric broad-spectrum antibiotics led to significant clinical improvement within days, with near-complete radiological resolution observed on follow-up imaging. CONCLUSIONS This case illustrates ARDS as a rare but serious complication of cosmetic fat-dissolving injections. While macroscopic fat embolism was excluded, the potential role of microscopic fat embolism remains a plausible mechanism. Clinicians should recognize that lipolysis injections, often regarded as minor aesthetic procedures, carry substantial potential pulmonary risks. Greater awareness, early intervention, and stricter regulation are essential to improve patient safety.