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Daily Report

Daily Cosmetic Research Analysis

03/30/2026
3 papers selected
29 analyzed

Analyzed 29 papers and selected 3 impactful papers.

Summary

Across cosmetic and reconstructive surgery and dermatologic prevention, three studies advanced practice-relevant evidence. A large survivor cohort identified persistent gaps in sun protection and physician skin exams, while two surgical series clarified drivers of durable outcomes in non-incisional double eyelid surgery and documented sustained functional gains after secondary cleft rhinoplasty.

Research Themes

  • Prevention and screening adherence in high-risk dermatology populations
  • Technique-driven outcomes in aesthetic eyelid surgery
  • Patient-reported functional gains after secondary cleft rhinoplasty

Selected Articles

1. Sun protection and skin cancer screening after childhood cancer-A report from the Swiss Childhood Cancer Survivor Study.

70Level IIICohort
Cancer · 2026PMID: 41906227

In a registry-linked national survivor survey (N=3579), regular sun protection was common but sunburns remained frequent, especially among adolescents and younger birth cohorts. Physician skin examination was underutilized, including after radiotherapy, whereas HSCT recipients were more likely to receive PSE; radiotherapy was paradoxically associated with fewer sunburns.

Impact: This high-quality population study identifies actionable gaps in dermatologic prevention and surveillance among high-risk survivors, directly informing survivorship care pathways.

Clinical Implications: Integrate annual physician skin exams into survivorship care for patients with prior radiotherapy or HSCT and emphasize consistent sun protection, with targeted interventions for adolescents and younger cohorts.

Key Findings

  • Regular sun protection reported by 89% of children, 65% of adolescents, and 77% of adults; sunburns occurred in 23%, 49%, and 43%, respectively.
  • Physician skin examination within the last year among radiotherapy recipients was low (21%, 18%, 17% across age groups), while HSCT recipients had higher PSE rates (36%, 28%, 28%).
  • Radiotherapy was associated with fewer sunburns (OR 0.63–0.77), whereas more recent birth cohorts had lower sun protection (OR 0.94–0.97) and higher sunburn risk (OR 1.04–1.14).

Methodological Strengths

  • Large, registry-linked sample with age-stratified multivariable analyses
  • Pre-registered study (NCT03297034) enhancing transparency

Limitations

  • Cross-sectional self-reported behaviors are subject to recall and social desirability bias
  • Causality cannot be inferred and clinician-level system factors for PSE were not captured

Future Directions: Implement and evaluate system-level interventions (e.g., automated survivorship prompts for annual PSE) and targeted behavioral programs for adolescents; link to objective UV exposure metrics.

BACKGROUND: Childhood cancer survivors (CCS) face elevated skin cancer risk, especially after radiotherapy or hematopoietic stem cell transplantation (HSCT). The authors evaluated the prevalence and predictors of sun protection, sunburn, and physician skin examination (PSE) among CCS in Switzerland. METHODS: The authors surveyed CCS diagnosed <21 years and surviving ≥5 years after diagnosis about sun protection, sunburns during last summer, and PSE within the last year. They retrieved cancer-related data from the Swiss Childhood Cancer Registry and used multivariable logistic regression, stratified by age group, to identify predictors. RESULTS: The authors included 1048 children (5-15 years), 572 adolescents (16-19 years), and 1959 adults (≥20 years). Regular sun protection was reported by 89% of children, 65% of adolescents, and 77% of adults, and sunburns by 23%, 49%, and 43%, respectively. PSE prevalence among those treated with radiotherapy was 21%, 18%, and 17%, and among HSCT recipients 36%, 28%, and 28%, respectively. Radiotherapy was unrelated to sun protection and PSE, but associated with fewer sunburns (odds ratio [OR], 0.63-0.77). HSCT recipients were more likely to have attended a PSE (OR, 2.06-3.75), but not radiotherapy recipients. Across age groups, survivors born more recently were less likely to protect from sun (OR, 0.94-0.97) and more likely to report sunburn (OR, 1.04-1.14). CONCLUSION: Sunburn prevalence was high despite good sun protection. Only few at heightened risk for skin cancer due to their treatment history attend PSEs as recommended by the Children's Oncology Group. Health care practitioners should systematically integrate yearly PSE after radiotherapy or HSCT and encourage consistent sun protection, particularly among younger generations and adolescents. TRIAL REGISTRATION: Clinicaltrials.gov (NCT03297034).

2. The HIROSHIMA Study: A High-Volume, Institutional, Retrospective, Observational Study of Hidden Non-Incisional Suture Double Eyelid Surgery for Multivariate Analysis of Crease Loss.

68.5Level IIICohort
Archives of plastic surgery · 2026PMID: 41907130

In 513 consecutive non-incisional double eyelid cases, crease survival depended primarily on fixation method and eyelid puffiness, not on surgeon experience. Continuous buried fixation outperformed other methods, especially in puffy eyelids, underscoring technique and anatomy over case volume.

Impact: Provides high-volume, multivariable evidence isolating modifiable technical factors for durable aesthetic outcomes in a globally common cosmetic procedure.

Clinical Implications: Prioritize continuous buried fixation and tailor designs for puffy eyelids to reduce crease loss; standardize training to focus on technique rather than case-count benchmarks.

Key Findings

  • In 513 cases, fixation method and eyelid puffiness were the strongest predictors of crease retention on Cox regression.
  • Continuous buried suture fixation showed superior crease survival, particularly in puffy eyelids.
  • Surgeon experience (<100 vs ≥100 cases) was not an independent predictor of crease loss after adjustment.

Methodological Strengths

  • Large consecutive series with Kaplan–Meier and Cox multivariable modeling
  • Direct comparison of technical and anatomical factors within a standardized setting

Limitations

  • Single-institution retrospective design limits generalizability
  • Outcome defined by revision need may miss subclinical or patient-tolerated crease attenuation

Future Directions: Prospective, multicenter trials comparing fixation strategies with standardized patient-reported and objective eyelid metrics; investigate suture materials and tissue biomechanics in puffy eyelids.

BACKGROUND: Non-incisional double eyelid surgery is widely performed in East Asia, but crease loss remains a major concern, leading to patient dissatisfaction and revision. The relative impact of surgical technique, anatomical characteristics, and surgeon experience on crease retention has not been fully clarified. METHODS: This retrospective, observational study included 513 consecutive patients who underwent transcutaneous, non-incisional double eyelid surgery between July 2021 and July 2022. Patients were stratified by surgeon experience (<100 vs. ≥100 prior cases). Baseline variables included age, sex, crease design, fixation method, puffy eyelid status, and surgeon experience. Crease loss was defined as the need for revision due to patient-reported fading or disappearance of the crease. Kaplan-Meier analysis and Cox proportional hazards regression were used to evaluate predictors of crease survival, including interaction terms for potential effect modification. RESULTS: Of 513 patients, 264 were treated by beginner surgeons, and 249 by experienced surgeons. Experienced surgeons more frequently used the continuous buried suture method ( CONCLUSION: Fixation method and eyelid puffiness were the primary determinants of crease retention, whereas surgeon experience was not an independent predictor. Continuous fixation provided superior outcomes, especially for patients with puffy eyelids. These findings suggest that, within standardized training systems, surgical technique and individualized anatomical consideration are more critical than case volume for achieving durable results in non-incisional double eyelid surgery.

3. Secondary Rhinoplasty in Unilateral Cleft Lip Nasal Deformity: A Longitudinal Assessment of Patient-Reported Satisfaction, Nasal Patency, and Olfactory Function.

67Level IIICohort
The Journal of craniofacial surgery · 2026PMID: 41911582

Among 144 UCLND patients undergoing secondary rhinoplasty, patient-reported satisfaction and olfactory perception improved at 6 months and remained elevated at 12 months. Subjective nasal obstruction (NOSE) did not change at 6 months but significantly improved by 12 months, suggesting progressive functional gains.

Impact: Provides rare longitudinal PRO data linking secondary cleft rhinoplasty to sustained functional and sensory benefits, informing counseling and timing of expectations.

Clinical Implications: Counsel patients that aesthetic satisfaction and olfaction may improve early, while perceived airway patency may continue to improve over the first postoperative year; incorporate PROs into routine follow-up.

Key Findings

  • ROE and olfactory VAS scores improved significantly at 6 months postoperatively (both P<0.001).
  • NOSE scores showed no change at 6 months (P=0.83) but improved significantly by 12 months (P=0.003).
  • At 12 months, ROE and olfactory VAS remained significantly higher than preoperative levels (both P<0.001).

Methodological Strengths

  • Prospective longitudinal assessment with validated PRO instruments (ROE, NOSE, VAS)
  • Reasonable sample size with 12-month follow-up subset

Limitations

  • Single-arm design without objective airway measures (e.g., rhinomanometry)
  • Attrition at 12 months (100/144 completed) may introduce follow-up bias

Future Directions: Add objective airflow and olfactory testing; compare surgical techniques; extend follow-up beyond 12 months to assess durability and revision rates.

Patients with unilateral cleft lip nasal deformities (UCLND) suffer from both cosmetic deformities and functional impairments. While secondary rhinoplasty primarily targets aesthetic enhancement, its long-term effects on patient-reported function, particularly airway patency and olfactory function, are not well-documented. The primary purpose of this study is to conduct a longitudinal assessment of patient-reported satisfaction, nasal patency, and olfactory function following secondary rhinoplasty in patients with UCLND. This study included 144 patients who underwent secondary rhinoplasty of UCLND between February 2022 and November 2023. Nasal morphology and function were assessed using the Rhinoplasty Outcome Evaluation (ROE) scale, Nasal Obstruction Symptom Evaluation (NOSE) scale, and the Visual Analog Scale (VAS) for olfactory function. A total of 144 patients were followed for 6 months postoperatively, of whom 100 completed an additional follow-up at 12 months. Comparison between preoperative and 6-month postoperative outcomes revealed significant improvements in both ROE and olfactory VAS scores (both P<0.001), whereas the NOSE score showed no statistically significant change (P=0.83). At 12 months postoperatively, ROE and olfactory VAS scores remained significantly elevated compared with preoperative levels, and the NOSE score demonstrated a significant reduction (P<0.001, P<0.001, and P=0.003, respectively). Secondary rhinoplasty for unilateral cleft lip nasal deformity has been shown to improve nasal satisfaction and subjective perception of nasal airway patency and olfactory sense. Notably, the improvement in patient-reported nasal patency appears to be a progressive and sustained process over time.