Daily Cosmetic Research Analysis
Analyzed 21 papers and selected 3 impactful papers.
Summary
Analyzed 21 papers and selected 3 impactful articles.
Selected Articles
1. Ultrasound-Assisted Facial Autologous Fat Grafting: A Systematic Review of Perioperative Safety and Volumetric Outcomes.
This PRISMA-registered systematic review of 12 studies (885 patients) finds that high-frequency ultrasound supports safer, more precise facial fat grafting by mapping vasculature, confirming cannula position in intended planes, and objectively monitoring retention. A comparative cohort showed higher injection volumes and satisfaction with ultrasound guidance, with no increase in complications and typical 50–70% one-year retention.
Impact: Synthesizes emerging evidence for ultrasound guidance in a high-risk cosmetic procedure, highlighting objective monitoring and safety without added complications. Establishes a foundation for standardized ultrasound protocols and outcome sets.
Clinical Implications: Adopt HFUS for preoperative vascular mapping, intraoperative plane confirmation, and postoperative retention monitoring in facial AFG. Develop standardized ultrasound protocols and core outcomes to enable comparative effectiveness and safety audits.
Key Findings
- Across 12 studies (885 patients), HFUS aided vascular mapping, filler characterization, and real-time cannula plane confirmation, with postoperative retention monitoring.
- In a comparative temple augmentation cohort, ultrasound guidance enabled higher injection volumes (22.32±5.19 vs 10.55±2.25 mL) and satisfaction (92% vs 74%) without increasing complications.
- Ultrasound-measured fat retention declined over 3–6 months and stabilized, with approximately 50–70% retention at 1 year, and higher retention after supplementary grafting (49.4% vs 71.7%).
Methodological Strengths
- PRISMA-compliant search with PROSPERO registration (CRD420251242117)
- Use of NIH quality assessment tools and multi-database search without language restrictions
Limitations
- Predominantly single-center observational studies with heterogeneity precluded meta-analysis of many outcomes
- Lack of standardized ultrasound protocols and core outcome sets; absence of randomized trials
Future Directions: Conduct multicenter comparative trials with standardized HFUS protocols and core outcomes to determine efficacy, cost-effectiveness, and training requirements.
High-frequency ultrasound (HFUS) is increasingly used to map facial vasculature and tissue planes, identify prior fillers, and objectively assess volume after autologous facial fat grafting (AFG), but its perioperative benefit has not been systematically synthesized. We performed a PRISMA-compliant systematic review (PROSPERO registration: CRD420251242117), searching PubMed, Embase, Web of Science Core Collection, and the Cochrane Library from inception to November 1, 2025, without language restrictions. We included human clinical studies using B-mode and/or Doppler ultrasound preoperatively, intraoperatively, or postoperatively and reporting safety and/or volumetric outcomes. Methodological quality was assessed using National Institutes of Health tools; due to heterogeneity, findings were narratively synthesized. Twelve studies (885 patients; 2017-2024) were included, predominantly single-center observational designs. Across studies, HFUS supported vascular mapping and filler characterization, real-time confirmation of cannula location within intended planes ("safe layers"), and postoperative monitoring of retention and complications. In a comparative temple augmentation cohort, ultrasound guidance enabled higher injection volumes (22.32±5.19 vs 10.55±2.25 mL) and higher satisfaction (92% vs 74%) without increased complications. Ultrasound-measured retention typically declined during the first 3-6 months and then stabilized, with ∼50-70% retention at 1 year and higher retention after supplementary grafting (49.4% vs 71.7% in one cohort). No study reported blindness, stroke, or skin necrosis; adverse events were generally mild and transient. Overall, HFUS-assisted facial AFG appears promising for risk stratification and objective monitoring, but higher-quality comparative studies with standardized ultrasound protocols and core outcome sets are needed.
2. A multicenter study on microsurgical procedures to treat congenital and acquired breast abnormalities.
In a multicenter retrospective cohort across four units (2010–2024), microsurgical procedures corrected diverse congenital and acquired breast abnormalities in 40 women and were deemed versatile and reliable. The authors advocate consideration of microsurgical reconstruction in non-oncologic patients, especially those with implant-related issues, tissue excess, or seeking natural aesthetics.
Impact: Provides multicenter, real-world evidence supporting microsurgical reconstruction as a viable alternative to implants, addressing aesthetic adaptability and complication profiles.
Clinical Implications: Consider microsurgical options for non-oncologic breast abnormalities, particularly in implant-related complications or in patients preferring autologous, natural results. Preoperative counseling should include donor-site considerations and potential need for refinements.
Key Findings
- Retrospective multicenter cohort across four plastic surgery units (2010–2024) included 40 women with congenital or acquired breast abnormalities.
- Microsurgical procedures were reported as versatile and reliable for correcting diverse abnormalities.
- Authors recommend considering microsurgical reconstruction even in non-oncologic patients, especially with implant complications, tissue excess, or desire for natural aesthetics.
Methodological Strengths
- Multicenter design spanning four units and a 15-year period
- Focus on real-world indications, techniques, and refinement surgeries
Limitations
- Retrospective design with modest sample size (n=40) and no control group
- Outcomes and complications not quantified in the abstract; potential selection bias
Future Directions: Prospective, comparative studies quantifying functional and aesthetic outcomes, patient-reported measures, complication rates, and cost-effectiveness versus implant-based approaches.
BACKGROUND: Breast abnormalities present complex reconstructive challenges requiring a tailored surgical approach combining both esthetic and reconstructive breast surgery. The purpose of this study was to evaluate the reliability of microsurgical procedures for the correction of breast abnormalities. METHODS: We conducted a retrospective multicenter study on female patients who underwent microsurgical procedures to correct congenital or acquired breast abnormalities in four plastic surgery units (January 2010-December 2024). The indications, microsurgical technique, and refinement surgeries were analyzed. RESULTS: In 40 patients (median age, 42 years; median BMI, 23.9 kg/m CONCLUSIONS: This multicenter study highlights the versatility and reliability of microsurgical procedures to correct breast abnormalities. Given the esthetic adaptability and evident advantages of microsurgical breast reconstruction in patients with breast cancer, this surgical approach should be considered as a valuable alternative in patients without cancer, particularly those with implant-associated complications, tissue excess, or younger individuals seeking a natural solution.
3. Cosmetic Exposure and Hepatic Steatosis: Investigating the Role of Metals and Adipokines.
In a 70-student panel, cosmetic use—especially hair and body products—was associated with higher hepatic steatosis indices (HSI, ZJU). Serum cobalt and copper showed dose–response associations with HSI, ZJU, and leptin, and leptin mediated links between cosmetics/metal exposure and steatosis indices.
Impact: Introduces preliminary human evidence connecting cosmetic product exposure and hepatic steatosis biomarkers through metal-associated adipokine pathways, highlighting an under-recognized public health concern.
Clinical Implications: While causal inference is not possible, clinicians should consider cosmetic exposures in lifestyle assessments for young adults at metabolic risk and support research-driven regulatory surveillance of metal contaminants.
Key Findings
- Cosmetic use, particularly hair and body products, was associated with higher HSI and ZJU hepatic steatosis indices.
- Serum cobalt (Co) and copper (Cu) exhibited positive dose–response relationships with HSI, ZJU, and leptin, independent of sex.
- Leptin mediated associations between lip/hair cosmetics, Co and Cu exposure, and increases in HSI and ZJU.
Methodological Strengths
- Multi-omics panel including 26 serum metals and adipokines with GLM and gWQS mixture modeling
- Causal mediation analysis to probe leptin’s mediating role
Limitations
- Small sample (n=70) and indirect steatosis measures (HSI, ZJU) limit generalizability and diagnostic specificity
- Observational design precludes causal inference; potential residual confounding
Future Directions: Larger prospective cohorts with imaging/biopsy-confirmed steatosis, longitudinal metal exposure profiling, and interventional studies reducing cosmetic metal exposure to test causality.
BACKGROUND: Cosmetic use is increasingly common among young college students; however, its potential link to hepatic steatosis remains unclear. This exploratory study examined associations between external cosmetic use, internal metal exposure, and hepatic steatosis indices, as well as the possible mediating roles of adipokines. METHODS: A panel study with 70 college students collected cosmetics exposure data, quantified serum levels of 26 metals, and measured plasma adipokine levels. Hepatic steatosis was assessed using the HSI and ZJU index as non-invasive indirect biomarkers. Generalized linear models (GLM) and generalized weighted quantile sum (gWQS) models evaluated associations between cosmetic and metal exposure with HSI, ZJU, and adipokines, including the interaction between sex and cosmetic exposure-related metals. Causal mediation analysis assessed adipokine mediation effects. RESULTS: Exposure to cosmetics, particularly hair and body products, was associated with elevated HSI and ZJU in college students. Cobalt (Co) and copper (Cu), biomarkers of cosmetic exposure, exhibited positive dose-response relationships with HSI, ZJU, and leptin, independent of sex. Leptin mediated the associations between lip and hair cosmetics, Co, Cu, and increased HSI and ZJU. CONCLUSIONS: Co and Cu biomarkers indicate an association between cosmetic use and biomarkers of hepatic steatosis in college students, in which leptin may play a mediating role. This exploratory study offers preliminary epidemiological evidence and suggests potential intervention targets for cosmetics-related liver health risks. However, given the indirect nature of HSI and ZJU and the observational design, causality cannot be inferred; further investigations are warranted.