Daily Cosmetic Research Analysis

DNA damage triggering senescence-associated secretory phenotype (SASP) is a key pathway of Intervertebral Disc Degeneration (IVDD). Current therapeutic strategies for IVDD face significant challenges in effectively alleviating DNA damage-mediated senescence of nucleus pulposus cells (NPCs) and IVDD repair. Here, we propose a strategy for the continuous regulation of DNA repair: starting with the scavenging of the key upstream trigger, ROS, proceeding to the repair of the DNA damage, and culminating in the promotion of DNA replication and extracellular matrix synthesis. Through single-cell sequencing of clinical samples and in vitro modeling, we elucidated how oxidative stress drives DNA damage, leading to SASP and inflammatory microenvironment within the intervertebral disc. Subsequently, we developed a continuous DNA repairing system. In this system, bimetallic-curcumin nanozymes (AuCu-Cur) scavenge ROS in NPCs and repair damaged DNA via the increased DNA glycosylase NEIL3. Additionally, the combined human umbilical cord-derived vesicles (hUCMSC-EVs) significantly enhance the bioavailability of the AuCu-Cur, promoting DNA replication, and promoting tissue repair via p-JNK pathway. In a rat tail needle puncture model, this system markedly alleviated IVDD. This study presents a promising approach to reverse the DNA damage-induced cellular senescence and IVDD, providing a repair strategy for addressing diseases associated with DNA damage and cellular senescence.

OBJECTIVE: This systematic review aimed to answer the clinically relevant question of whether lesion location (midline versus periorbital) is associated with differences in risk of intracranial extension, operative strategy, and recurrence in pediatric frontonasal and orbital dermoid cysts. DATA SOURCES: MEDLINE, Embase, Cochrane Library, and ScienceDirect were searched for studies published between 2000 and 2025. REVIEW METHODS: Eligible studies included pediatric patients with histopathologically confirmed dermoid cysts involving the frontonasal or periorbital regions. Data on demographics, lesion location, intracranial extension, surgical approach, and recurrence were extracted and synthesized. RESULTS: 39 studies encompassing 766 pediatric patients were included. Patients were divided into three groups: Type I (37.9%) - lateral dermoids (eyebrow/orbital); Type II (42%) - midline superficial dermoids without a sinus tract; and Type III (20.1%) - midline dermoids with a sinus tract, with or without intracranial extension. Intracranial extension was identified in 68 of 766 patients. Almost all cases occurred in children with midline lesions; only two patients with orbital dermoid cysts had intracranial extension. Recurrence occurred in 29 of 763 evaluable patients. CONCLUSIONS: This systematic review demonstrates that lesion location is the key determinant of clinical behavior in pediatric frontonasal and orbital dermoid cysts. Lateral periorbital lesions are typically superficial and associated with a low risk of complications, whereas midline lesions carry a significantly higher risk of sinus tract formation, intracranial extension, and postoperative recurrence. The choice of surgical approach should be individualized based on lesion location, depth, and extension, balancing adequate exposure with optimal cosmetic and functional outcomes.

Per- and polyfluoroalkyl substances (PFAS) have long been valued for their chemical stability, hydrophobicity, oleophobicity, and thermal resistance, supporting applications in firefighting foams, textiles, food packaging, medical devices, electronics, and industrial surfactants. However, growing evidence of environmental persistence and health risks has prompted regulatory restrictions and a shift toward PFAS-free alternatives. This review assesses PFAS-free substitutes across key sectors, examining their chemical and functional mechanisms, performance trade-offs, safety profiles, and market readiness. Fluorine-free foams, silicone and hydrocarbon-based textile coatings, biobased and synthetic polymer food packaging, alkyl polyglucosides and silicone surfactants, plant-derived cosmetic emollients, hydrophilic and zwitterionic polymers for medical devices, and PFAS-free photoresists are examined for their efficacy and sustainability potential. To situate these developments within a broader socio-environmental context, a Driving forces-Pressures-State-Impacts-Responses (DPSIR)-based framework is applied to assess sectoral substitution urgency. A comparative ranking indicates very high urgency for firefighting foams and food packaging, high urgency for textiles and industrial surfactants, moderate-high urgency for cosmetics and personal care products, moderate urgency for electronics and semiconductors, and moderate/targeted urgency for medical devices. Sensitivity analysis under alternative weighting scenarios confirms complete stability of sectoral rankings, demonstrating robustness of the prioritisation framework. Regional adoption patterns, regulatory drivers, and implementation barriers, particularly in low- and middle-income countries, are discussed, emphasising the need for harmonised standards, knowledge-sharing, and innovation support. Overall, while PFAS-free alternatives exhibit application-dependent functional viability, trade-offs in durability, chemical resistance, and operational efficiency remain, underscoring opportunities for continued materials innovation toward reducing reliance on PFAS.