Efficacy of different endodontic irrigants in the lesion sterilization and tissue repair technique in primary molars: A randomized controlled clinical trial.

Summary

In a randomized trial of 40 children undergoing LSTR for primary molars, chlorhexidine yielded the best clinical outcomes and the least root resorption, while sodium hypochlorite produced the greatest reduction in furcation radiolucency. All irrigants outperformed saline, supporting irrigant use prior to alternate 3-Mix placement.

Key Findings

• All irrigant groups achieved clinical success compared with saline (P < 0.05).
• 2% chlorhexidine showed the best clinical outcomes and the least root resorption.
• 2% sodium hypochlorite produced the greatest reduction in furcation radiolucency.
• Follow-up extended to 18 months with consistent clinical and radiographic evaluation.

Clinical Implications

For pediatric LSTR, chlorhexidine may be preferred for overall clinical success and minimal root resorption, while sodium hypochlorite may be selected when radiographic lesion size reduction is prioritized.

Limitations

• Single-center study with a modest sample size (n=40)
• Blinding and allocation concealment procedures are not detailed

Future Directions

Conduct larger, multicenter RCTs with standardized outcome measures and microbiological endpoints, and extend follow-up to natural exfoliation.