Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products.
Summary
A TAPB-DMTP COF nanofilm used as an LDI-MS substrate yields stronger signals and cleaner backgrounds than standard organic matrices for small molecules. The method quantifies BP-1 in personal care products with excellent linearity (1–20 μg/mL, r=0.9993), low LOD (0.3 μg/mL), robust reproducibility (RSD 6.10%), and 30-day stability, supporting sensitive surveillance of endocrine-disrupting UV filters.
Key Findings
- COF nanofilm-assisted LDI-MS produced stronger signals and cleaner backgrounds than CHCA, DHB, and SA for small-molecule analysis.
- Demonstrated high reproducibility (RSD 6.10%) and stability up to 30 days.
- Quantified BP-1 with excellent linearity (1–20 μg/mL, r=0.9993), low LOD (0.3 μg/mL), and recoveries of 94.2%–104.4% in personal care products.
Clinical Implications
Supports faster, more reliable screening of endocrine-disrupting UV filters in personal care products, informing regulatory compliance, product reformulation, and public health risk assessment.
Why It Matters
Provides a practical, scalable analytical platform for detecting benzophenone UV filters in complex cosmetic matrices, enabling regulatory monitoring and exposure assessment. The COF-LDI-MS approach is broadly applicable to other small molecules beyond cosmetics.
Limitations
- Focused quantification on BP-1; broader validation across more benzophenones and other UV filters is needed.
- Single-laboratory evaluation without inter-lab reproducibility studies.
Future Directions
Extend the COF-LDI-MS platform to a panel of UV filters and cosmetic additives; conduct inter-lab validation and standardize protocols for regulatory adoption.
Study Information
- Study Type
- Case series
- Research Domain
- Diagnosis
- Evidence Level
- V - Method development and validation study without clinical subjects.
- Study Design
- OTHER