Efficacy of a bioflavonoid-enriched herbal versus 0.12% and 0.2% chlorhexidine mouthwashes in reducing peri-implant inflammation and subgingival Porphyromonas gingivalis carriage in patients with peri-implantitis.

Summary

After mechanical debridement, a bioflavonoid-enriched herbal mouthwash achieved greater 90-day reductions in plaque, bleeding, probing depth, and subgingival P. gingivalis than both 0.12% and 0.2% chlorhexidine. Findings support a herbal alternative for peri-implantitis maintenance.

Key Findings

• Randomized trial (n=67) comparing herbal bioflavonoid mouthwash vs 0.12% and 0.2% chlorhexidine over 90 days.
• Greater reductions in mPI, mBI, and PD with the herbal mouthwash compared with both CHX groups (P<0.05).
• Subgingival P. gingivalis carriage fell to 13.6% with the herbal rinse vs 50.0% and 54.5% with 0.12% and 0.2% CHX.

Clinical Implications

Clinicians may consider bioflavonoid herbal rinses post-debridement to reduce inflammation and P. gingivalis in peri-implantitis patients; confirmatory multicenter trials and safety/tolerability profiling are warranted.

Limitations

• Single-center, modest sample size with 90-day follow-up
• Blinding and allocation concealment not described; adverse events not detailed

Future Directions

Multicenter, blinded RCTs with longer follow-up to assess durability, safety, and effects on bone loss and implant survival.