Daily Cosmetic Research Analysis
Surgical technique matters in aesthetic oncologic breast surgery: a large multicenter cohort shows tumescence and sharp dissection lowers necrosis, infection, and implant loss in minimal-access nipple-sparing mastectomy without compromising 5-year survival. Safety science for aerosolized cosmetics is advancing through lung organoids, offering more human-relevant inhalation risk assessment. A scoping review highlights long-term cosmetic dissatisfaction after childhood sexual assault reconstructiv
Summary
Surgical technique matters in aesthetic oncologic breast surgery: a large multicenter cohort shows tumescence and sharp dissection lowers necrosis, infection, and implant loss in minimal-access nipple-sparing mastectomy without compromising 5-year survival. Safety science for aerosolized cosmetics is advancing through lung organoids, offering more human-relevant inhalation risk assessment. A scoping review highlights long-term cosmetic dissatisfaction after childhood sexual assault reconstructive surgery and calls for standardized follow-up.
Research Themes
- Technique optimization in aesthetic-oncologic breast surgery
- Organoid-based inhalation toxicology for cosmetic aerosols
- Long-term aesthetic and quality-of-life outcomes after genital reconstructive surgery
Selected Articles
1. Surgical and Oncologic Outcomes of Tumescence and Sharp Dissection Versus Electrocautery Dissection in Minimal-Access Nipple-Sparing Mastectomy with Immediate Prosthesis Breast Reconstruction: A Real-World Retrospective Cohort Study.
In a multicenter, propensity-matched cohort of 1252 minimal-access NSM with immediate implant reconstructions, tumescence plus sharp dissection significantly reduced flap necrosis, infection, and implant loss versus electrocautery dissection, and shortened operative time. Five-year overall and disease-free survival did not differ between techniques.
Impact: This large, real-world comparative study identifies an immediately actionable technique to reduce complications in aesthetic-oncologic breast surgery without compromising survival.
Clinical Implications: Adopting tumescence with sharp dissection for minimal-access NSM may lower flap-related complications and implant loss, improve cosmetic outcomes, and shorten operative time without affecting oncologic safety.
Key Findings
- Propensity-matched cohort of 1252 cases across 12 centers compared tumescence+sharp dissection vs electrocautery.
- Lower necrotic complications (5.8% vs 13.0%; p=0.001), infections (2.6% vs 5.6%; p=0.041), and implant loss (0.3% vs 2.2%; p=0.025) with tumescence+sharp dissection.
- Shorter operation time with tumescence+sharp dissection (median 177 vs 201 minutes; p<0.001).
- No significant differences in 5-year overall survival (p=0.938) or disease-free survival (p=0.893).
Methodological Strengths
- Large multicenter real-world dataset with propensity score matching
- Clinically meaningful endpoints including complications and 5-year survival
Limitations
- Retrospective design may be prone to residual confounding despite matching
- Technique selection bias and unmeasured surgeon-level factors cannot be excluded
Future Directions: Prospective, ideally randomized or registry-based comparative studies quantifying patient-reported outcomes and detailed cosmetic assessments would strengthen causal inference and guide guideline updates.
2. The Risks Associated with Inhalation Exposure to Cosmetics and Potential for Assessment Using Lung Organoids.
This review synthesizes how lung organoids can model human-relevant responses to aerosolized cosmetic exposure, addressing limitations of traditional inhalation toxicology. It outlines organoid construction, comparative advantages, and early applications to assess spray product safety.
Impact: Introduces a mechanistically informed, human-relevant test system to improve safety assessments for aerosolized cosmetics and potentially reduce animal testing.
Clinical Implications: While preclinical, organoid-based inhalation assays can inform formulation changes to mitigate respiratory risks for consumers and workers exposed to cosmetic aerosols.
Key Findings
- Aerosolized cosmetic products present inhalation exposure risks inadequately captured by traditional assessment methods.
- Lung organoids derived from stem cells provide 3D, multicellular structures that better mimic human lung responses.
- Emerging studies demonstrate feasibility of using lung organoids to evaluate cosmetic aerosol effects, supporting regulatory safety assessments.
Methodological Strengths
- Integrative overview of organoid construction and comparative advantages over traditional models
- Translational focus linking preclinical organoid data to regulatory safety assessment needs
Limitations
- Narrative review without formal PRISMA methodology or quantitative synthesis
- Limited number of published cosmetic-specific organoid inhalation studies to date
Future Directions: Develop standardized lung organoid inhalation exposure protocols, inter-lab validation, and benchmarking against human exposure data to support regulatory adoption.
3. Long-term cosmetic and quality of life outcomes after surgery for genital, anogenital, or urogenital injuries resulting from childhood sexual abuse: A scoping review.
Across 12 included studies of reconstructive surgery after childhood sexual assault (before age 10), most patients reported dissatisfaction with external genital cosmetic appearance but satisfactory urinary and fecal continence. Evidence on chronic pain, sexual function, and psychological outcomes is sparse, underscoring the need for standardized long-term follow-up.
Impact: Highlights critical gaps in long-term aesthetic and quality-of-life outcomes after pediatric genital reconstructive surgery, guiding future standards of care and follow-up.
Clinical Implications: Establish standardized, trauma-informed long-term follow-up including validated measures of cosmetic satisfaction, pain, sexual function, and psychological health to tailor care.
Key Findings
- Systematic scoping review following PRISMA-ScR identified 12 studies from 962 records.
- Most patients were dissatisfied with external genital cosmetic outcomes after reconstructive surgery.
- Urinary and fecal continence satisfaction was generally high.
- Little data on chronic pain, sexual function, and psychological outcomes; lack of standardized long-term follow-up protocols.
Methodological Strengths
- PRISMA-ScR–conformant scoping methodology with multi-database search
- Dual independent extraction using Covidence
Limitations
- Only 12 studies with heterogeneous designs limit generalizability
- Lack of standardized outcome measures across studies
Future Directions: Develop consensus core outcome sets (cosmetic satisfaction, continence, sexual and psychological health) and prospective registries to capture long-term trajectories.