Daily Cosmetic Research Analysis

BACKGROUND: For minimally-invasive surgery (MIS), there are numerous acceptable port-site closure techniques with no consensus on the method used. AIM: To identify optimal port site postoperative wound closure method following MIS with respect to complication rates and cosmetic outcome. METHODS: Network meta-analysis (NMA) was performed in accordance with PRISMA-NMA guidelines for RCTs comparing at least two methods of port-site closure. RESULTS: Nineteen RCTs were identified evaluating eight methods of wound closure in 1,932 patients; across three types of suture, three forms of tissue glue, staples and paper-tape. At NMA, there was no significant difference in wound complication, infection, dehiscence or pain rate irrespective of closure method, albeit a trend towards higher rate of dehiscence for adhesives. At NMA, wound cosmesis was superior for adhesives at both early and late postoperative follow-up. CONCLUSION: This study validates the use of tissue adhesives with respect to primary closure of port sites following MIS while highlighting potential associated risks.

PURPOSE OF REVIEW: Chemical (organic) ultraviolet (UV) filters-carbon-based compounds widely used in sunscreen formulations-are essential for protecting against harmful UV radiation. However, emerging evidence over the last decade (2014-2024) has raised concerns regarding their potential endocrine-disrupting effects, environmental persistence, and bioaccumulation. This comprehensive review evaluates the endocrine, reproductive, and developmental health impacts of organic UV filters, with a focus on benzophenone derivatives such as BP-3, BP-2, and 4-OHBP. RECENT FINDINGS: The analysis incorporates data from 75 studies identified through PRISMA-guided screening of epidemiological and human research. Findings reveal significant hormonal disruptions, including reduced testosterone levels in adolescent males, altered thyroid hormones in pregnant women, and associations with delayed pubertal development in boys and early menarche in girls. Mixed exposures to multiple UV filters, frequently occurring in real-world scenarios, demonstrate cumulative and complex effects, particularly on thyroid hormone levels and reproductive health. In men, benzophenones are associated with decreased sperm quality and motility, while in women, their impact on ovarian reserve and fertility outcomes appears less pronounced. Prenatal exposure studies show mixed outcomes, ranging from reduced neonatal size and gestational age to increased placental-to-birth weight ratios. This review underscores the dual nature of organic UV filters, emphasizing their importance in photoprotection while highlighting the need for a balanced approach to safety evaluations. Future research should prioritize long-term cohort studies, assessments of mixed exposure effects, and the development of safer alternatives. Addressing these challenges is crucial for mitigating risks to human health and the environment while maintaining the protective benefits of sunscreens.

OBJECTIVE: Septorhinoplasties are a common surgery. Effectively managing postoperative pain and identifying opioid reduction techniques is of critical importance. This systematic review characterizes the literature regarding the management of postoperative pain with opioid-based and opioid alternative therapies in patients undergoing septorhinoplasty. DATA SOURCES: Medline (Ovid), Embase (Elsevier), Cochrane Library (Wiley), and Web of Science (Clarivate). REVIEW METHODS: A literature search was conducted using multiple medical subject headings (MeSH) and keywords with adherence to preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. Full-text analysis was performed by two independent reviewers using the Critical Appraisal Skills Program (CASP) and National Institute for Health and Clinical Excellence (NICE) validated quality assessment tools. RESULTS: A total of 2503 articles were identified, and 14 studies met inclusion criteria. In the five opioid-based studies, patients were prescribed 10-60 opioid tablets, with consumption of 4.9-14.7 opioid tablets. Six pharmacologic opioid alternative therapy studies included sphenopalatine ganglion block, gabapentin, and nonsteroidal anti-inflammatory drugs (NSAIDs), all of which demonstrated either equivalent or improved pain control compared to opioid medications. Three nonpharmacologic opioid alternative studies were included, and one showed that vibration therapy reduced pain scores. CONCLUSION: While studies examining postoperative pain control in septorhinoplasty are heterogeneous, our findings suggest that opioids are prescribed in excess of exhibited need. Areas of consideration for opioid alternative multimodal pain control include gabapentin, celecoxib, ibuprofen, or other NSAID therapies, and local anesthetic blocks. Additional studies are needed to further examine minimizing opioids in postoperative pain control.