Daily Cosmetic Research Analysis
Across aesthetics-focused care, a network meta-analysis supports tissue adhesives for minimally invasive surgery port-site closure due to superior cosmetic outcomes without excess complications, a PRISMA-guided review flags endocrine and reproductive concerns with common sunscreen UV filters, and a systematic review in septorhinoplasty highlights opioid overprescription and effective opioid-sparing strategies.
Summary
Across aesthetics-focused care, a network meta-analysis supports tissue adhesives for minimally invasive surgery port-site closure due to superior cosmetic outcomes without excess complications, a PRISMA-guided review flags endocrine and reproductive concerns with common sunscreen UV filters, and a systematic review in septorhinoplasty highlights opioid overprescription and effective opioid-sparing strategies.
Research Themes
- Evidence-based wound closure for better cosmesis
- Sunscreen UV filter endocrine and reproductive safety
- Opioid-sparing analgesia in aesthetic surgery
Selected Articles
1. Optimal port site skin closure method following minimally-invasive surgery: A systematic review and network meta-analysis of randomised clinical trials.
Across 19 RCTs (n=1,932), tissue adhesives achieved superior cosmetic outcomes for MIS port-site closure without significant differences in wound complications, infection, dehiscence, or pain, although a trend toward higher dehiscence with adhesives was noted. Findings support adhesives as a primary closure option while underscoring vigilance for dehiscence.
Impact: This NMA synthesizes randomized evidence to guide an everyday surgical choice that directly affects scarring and patient satisfaction, clarifying trade-offs between cosmesis and dehiscence risk.
Clinical Implications: Consider tissue adhesives as first-line for MIS port-site skin closure to optimize scar appearance, paired with protocols for dehiscence monitoring and patient selection (e.g., tension, location, comorbidity).
Key Findings
- Nineteen RCTs (n=1,932) compared 8 closure methods (sutures, tissue glues, staples, paper-tape).
- No significant differences across methods in wound complications, infection, dehiscence, or pain.
- Tissue adhesives produced superior cosmetic outcomes at early and late follow-up.
- A trend toward higher dehiscence rates with adhesives was observed.
Methodological Strengths
- PRISMA-NMA compliant network meta-analysis of randomized trials
- Broad comparison across multiple closure modalities with indirect and direct evidence synthesis
Limitations
- Potential heterogeneity in outcome assessment and follow-up intervals across RCTs
- Observed trend toward higher dehiscence with adhesives needs patient-level analysis to identify moderators
Future Directions: Individual patient data NMA to stratify dehiscence risk (wound tension, BMI, diabetes), cost-effectiveness analyses, and standardized cosmesis metrics for long-term outcomes.
2. Endocrine and Reproductive Health Considerations of Sunscreen UV Filters: Insights from a Comprehensive Review 2014-2024.
A PRISMA-guided synthesis of 75 human/epidemiological studies links certain organic UV filters—especially benzophenones—to hormonal disruptions (testosterone reduction in adolescent males, thyroid alterations in pregnancy), pubertal timing shifts, decreased sperm quality, and mixed prenatal outcomes. The review balances photoprotection benefits with evidence gaps, calling for long-term mixed-exposure studies and safer alternatives.
Impact: Sunscreen use is ubiquitous; synthesizing human data on endocrine and reproductive risks directly informs public health guidance, regulatory policy, and formulation choices.
Clinical Implications: Advise continued photoprotection while minimizing unnecessary chemical UV filter exposure (e.g., use of mineral sunscreens in sensitive groups) and monitor at-risk populations (adolescents, pregnant women) as evidence evolves.
Key Findings
- PRISMA-guided review of 75 human/epidemiological studies on organic UV filters with emphasis on benzophenones (BP-3, BP-2, 4-OHBP).
- Associations with reduced testosterone in adolescent males and altered thyroid hormones in pregnant women.
- Links to delayed puberty in boys and earlier menarche in girls; decreased sperm quality and motility in men.
- Mixed prenatal outcomes, including changes in neonatal size, gestational age, and placental-to-birth weight ratios.
- Mixed exposures to multiple UV filters show cumulative and complex endocrine effects.
Methodological Strengths
- PRISMA-guided comprehensive screening and inclusion of human/epidemiologic evidence
- Focus on real-world mixed exposures reflecting cumulative effects
Limitations
- Heterogeneity of exposure assessment and outcomes limits causal inference
- Lack of quantitative meta-analysis and residual confounding in observational data
Future Directions: Prospective longitudinal cohorts with standardized biomonitoring, mixture modeling of UV filter co-exposures, and development/testing of safer sunscreen alternatives.
3. Management of Postoperative Pain in Septorhinoplasty: A Systematic Review.
Across 14 studies, septorhinoplasty patients were prescribed substantially more opioids than they consumed, while alternatives such as sphenopalatine ganglion block, gabapentin, and NSAIDs achieved comparable or superior analgesia. Limited evidence also supports vibration therapy, underscoring opportunities for multimodal opioid-sparing regimens.
Impact: This review targets a highly common cosmetic-functional surgery and provides concrete avenues to reduce opioid exposure without sacrificing pain control.
Clinical Implications: Adopt multimodal analgesia prioritizing NSAIDs (e.g., ibuprofen, celecoxib), gabapentin, and regional blocks; right-size opioid prescriptions based on typical consumption patterns.
Key Findings
- Among five opioid-focused studies, patients received 10–60 tablets but used only 4.9–14.7 tablets.
- Pharmacologic alternatives (sphenopalatine ganglion block, gabapentin, NSAIDs) provided equivalent or better pain control versus opioids.
- A nonpharmacologic intervention (vibration therapy) reduced pain scores in one study.
- Heterogeneity across studies suggests a need for standardized protocols and outcomes.
Methodological Strengths
- PRISMA-adherent systematic review across multiple databases
- Independent dual-reviewer screening and quality appraisal (CASP/NICE tools)
Limitations
- Heterogeneous designs and outcomes, precluding robust meta-analysis
- Limited high-quality RCT data for some alternatives and nonpharmacologic modalities
Future Directions: Conduct adequately powered RCTs comparing multimodal regimens, standardize pain and function outcomes, and develop prescribing guidelines tailored to septorhinoplasty.