Daily Cosmetic Research Analysis
A multicenter cohort with GWAS refined risk prediction for striae gravidarum in pregnancy. A 43-country, AI-enhanced survey revealed broad public distrust of live cosmetic procedure demonstrations and proposed the INFORM-A ethics checklist. Method validation work showed ISO 23675 (in vitro SPF “double plate” method) reliably measures SPF in zinc oxide-based sunscreens, supporting reproducible, human-sparing testing.
Summary
A multicenter cohort with GWAS refined risk prediction for striae gravidarum in pregnancy. A 43-country, AI-enhanced survey revealed broad public distrust of live cosmetic procedure demonstrations and proposed the INFORM-A ethics checklist. Method validation work showed ISO 23675 (in vitro SPF “double plate” method) reliably measures SPF in zinc oxide-based sunscreens, supporting reproducible, human-sparing testing.
Research Themes
- Genetic risk and prediction in cosmetic dermatology
- Ethics and public trust in aesthetic practice
- Standardization of in vitro SPF testing for inorganic sunscreens
Selected Articles
1. Striae gravidarum in the Han Chinese pregnant population: identifying genetic markers and risk factors through a prospective cohort study.
In a multicenter prospective cohort of 1,017 Han Chinese pregnant women, 59% developed striae gravidarum. Age, family history, prior adolescent striae, Fitzpatrick skin type, and pre-pregnancy BMI were key predictors, and GWAS implicated SNPs in FGF12, RAB38, MUC16, PTPRT, SIPA1L2, PPARGC1A, PTPRD, and ELOVL3. The authors propose a risk model integrating modifiable and non-modifiable factors to guide counseling.
Impact: This is a large, prospective cohort with a GWAS that identifies genetic loci and clinical predictors of striae gravidarum, advancing mechanistic understanding and enabling risk stratification.
Clinical Implications: Enables counseling on modifiable risks (e.g., pre-pregnancy weight/BMI) and sets the stage for personalized prevention strategies safe during pregnancy and postpartum.
Key Findings
- SG incidence was 59% in the cohort.
- Significant associations with age, pre-pregnancy weight/BMI, maximum pregnancy weight, BMI during pregnancy, and maximum abdominal girth.
- Risk factors included family history, prior adolescent striae, and Fitzpatrick skin type.
- Multivariable logistic regression identified age, family history, prior striae, skin type, and pre-pregnancy BMI as predictors.
- GWAS implicated SNPs in FGF12, RAB38, MUC16, PTPRT, SIPA1L2, PPARGC1A, PTPRD, and ELOVL3 in SG presence and severity.
Methodological Strengths
- Prospective multicenter design with sizable sample (n=1,017).
- Integration of GWAS with multivariable regression to identify predictors.
Limitations
- Generalisability may be limited to Han Chinese; external validation is needed.
- Observational design precludes causal inference and may be subject to residual confounding.
Future Directions: External validation across diverse populations; functional studies of implicated loci; development and clinical testing of personalized, pregnancy-safe prevention strategies.
2. 'Your Face, Their Stage': A Global, AI-Enhanced, Mixed-Methods Survey on Public Perceptions of Live Educational Cosmetic Procedures.
A multilingual cross-sectional survey of 16,950 respondents across 43 countries found widespread ethical discomfort with live cosmetic procedure demonstrations: 76.5% perceived self-promotion and 69.7% privacy compromise. AI/NLP analyses showed nearly half of narratives were negative (dominant emotions: disgust, concern), and ML models (AUC 0.82, F1 0.765) identified predictors of negative sentiment. The authors propose the INFORM-A checklist to guide ethical broadcasting.
Impact: This large, AI-enhanced, mixed-methods study quantifies global public concerns around live cosmetic procedures and provides an actionable ethical framework (INFORM-A) likely to influence professional standards and conference practices.
Clinical Implications: Encourages shifting from live procedural demonstrations to consent-driven, accountable, recorded educational formats; enhances privacy, autonomy, and psychological safety in aesthetic practice.
Key Findings
- 76.5% of respondents believed live procedures are self-promotional.
- 69.7% perceived live procedures as compromising patient privacy.
- 49.8% of narratives were negative; dominant emotions were disgust (24.3%) and concern (22.8%).
- Topic modeling highlighted concerns including commercial exploitation (22.5%), consent power imbalance (19.3%), and surveillance culture (14.2%).
- Predictive models achieved AUC 0.82 and F1 0.765; key predictors included narrative polarity, region, emotional tone, and prior cosmetic experience.
- The INFORM-A checklist was proposed to guide ethical conduct of live/recorded procedural broadcasts.
Methodological Strengths
- Very large, multilingual global sample with mixed-methods design.
- AI-enhanced analytics (NLP, sentiment analysis, ML) with reported performance metrics (AUC, F1).
Limitations
- Cross-sectional design limits causal inference; potential self-selection and response biases.
- Public perceptions may not reflect clinical outcomes or professional educational needs.
Future Directions: Assess the impact of implementing INFORM-A on patient outcomes and trust; replicate with clinician and patient cohorts; develop policy and accreditation standards for educational broadcasts.
3. The double plate in vitro SPF test method (ISO23675:2024) is a reliable means of measuring the performance of sunscreen products with high concentrations of zinc oxide and inorganic-only UV filters.
Using ISO 23675 (in vitro SPF 'double plate' method), the authors directly measured zinc oxide-based sunscreens and demonstrated reliable SPF determination even at high inorganic filter concentrations. Critiques based on non-ISO in vitro approaches do not apply to ISO 23675, supporting its adoption for inorganic-only formulations.
Impact: Validates a newly standardized in vitro SPF method for inorganic sunscreens, improving reproducibility and reducing reliance on in vivo testing, with direct implications for product labeling and regulation.
Clinical Implications: Supports clinicians and consumers in trusting in vitro SPF values for zinc oxide-based sunscreens; facilitates ethically preferable testing and more consistent labeling for inorganic filter products.
Key Findings
- Direct ISO 23675 measurements showed reliable SPF determination for ZnO-based sunscreens, even at high inorganic filter concentrations.
- Assumptions and limitations from other in vitro methods do not apply to ISO 23675.
- The work supports adopting ISO 23675 as a robust alternative to ISO 24444 in vivo testing for inorganic-only formulations.
Methodological Strengths
- Use of a standardized ISO method (ISO 23675) tailored for in vitro SPF assessment.
- Direct testing on ZnO-based formulations addressing a specific controversy about inorganic filters.
Limitations
- Number and types of tested products are not detailed in the abstract, limiting assessment of generalizability.
- Quantitative concordance with in vivo ISO 24444 is not presented in the abstract.
Future Directions: Inter-laboratory ring trials, comprehensive datasets spanning diverse vehicles and particle sizes, and systematic correlation studies with ISO 24444 to strengthen regulatory adoption.