Cosmetic Research Analysis
September’s cosmetic research centered on safety surveillance, standardized testing, and procedural risk reduction. A non-targeted analytics pipeline (FBMN + QSIIR + in silico toxicity) advanced detection of concealed cosmetic adulterants. ISO 23675 validated an in vitro Double Plate SPF method that can reduce human testing burden while improving label confidence. A PRISMA meta-analysis quantified facial artery course, diameter, and depth via Doppler ultrasound, translating directly into safer f
Summary
September’s cosmetic research centered on safety surveillance, standardized testing, and procedural risk reduction. A non-targeted analytics pipeline (FBMN + QSIIR + in silico toxicity) advanced detection of concealed cosmetic adulterants. ISO 23675 validated an in vitro Double Plate SPF method that can reduce human testing burden while improving label confidence. A PRISMA meta-analysis quantified facial artery course, diameter, and depth via Doppler ultrasound, translating directly into safer filler planning.
Selected Articles
1. A novel integrated strategy combining feature-based molecular networking, QSIIR modeling, and in silico toxicity prediction accelerates the screening of illegal additives in cosmetics: Quinolones as a case study.
An integrated non-targeted pipeline (FBMN + QSIIR MLR + in silico toxicity) clustered 51 quinolones (14 novel analogs) into 13 groups, achieved ~1 ppm LOD, and predicted concentrations from structural descriptors, enabling rapid prioritization of hazardous cosmetic adulterants.
Impact: Delivers a scalable surveillance workflow to uncover concealed and novel adulterants with minimal reliance on reference standards.
Clinical Implications: Supports early detection and recall actions by public health labs and regulators, and helps clinicians link adverse skin reactions to illicit agents.
Key Findings
- FBMN clustered 51 quinolones (14 novel analogs) into 13 structural groups from 17 seed standards.
- Limit of detection ~1 ppm in cosmetic matrices.
- QSIIR MLR with seven descriptors accurately predicted concentrations.
- In silico toxicity scoring prioritized high-risk candidates.
2. Performance assessment of the Double Plate method (ISO23675) in ALT-SPF Consortium: A highly reproducible and accurate in vitro method to determine SPF.
A five-lab ring test across 32 formulations showed excellent intra-/inter-lab precision and accuracy (after mathematical adjustment) versus the ISO 24444:2019 in vivo reference, supporting ISO 23675 publication and scalable non-animal SPF testing.
Impact: Operationalizes a validated in vitro standard that can reduce human testing and improve label reliability for sunscreens.
Clinical Implications: Supports consistent photoprotection counseling by clinicians through more reliable SPF labels and may streamline regulatory pathways.
Key Findings
- Met ISO precision criteria with high intra- and inter-laboratory reproducibility.
- Mathematical adjustment aligned in vitro outputs with ISO 24444:2019 in vivo reference.
- Robotic application and spectrophotometry minimized operator variability.
3. Evaluation of Facial Artery Course Variations, Diameters, and Depth Using Doppler Ultrasonography: A Systematic Review and Meta-Analysis.
A PRISMA meta-analysis found near-universal facial artery visualization across three facial levels and quantified course variations, depth, and diameter, yielding actionable pre-procedural maps to reduce intravascular filler injections.
Impact: Translates pooled anatomical evidence into ultrasound protocols and injection-plane guidance for safer aesthetic procedures.
Clinical Implications: Supports routine pre-procedural Doppler mapping to inform device choice and injection depth, lowering ischemic complication risks.
Key Findings
- ≈100% visualization of the facial artery across three facial levels by Doppler ultrasound.
- Most common course relative to the nasolabial fold was medial; depth increased and diameter decreased cranially.
- Angular artery as the prevalent terminal branch.