2025 Sepsis Research Analysis
Sepsis research in 2025 underwent a decisive transition from syndrome-level treatment toward biologically stratified, time-dependent, and organ-specific precision medicine. Large human multi-omic studies demonstrated that infection source, age, immune state, and longitudinal molecular trajectories are major determinants of heterogeneity. Several studies established biomarker-to-mechanism-to-therapy chains involving immune collapse, endothelial injury, immunometabolism, pyroptosis, and mitochondr